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Enzyme shown to help protect genomic stability

...at the ends of the chromosomes known as telomeres, has been linked to aging in humans and an elevated ris...igation led by researchers at The Wistar Institute has shown that an enzyme known as Ubp10 plays a vital role in protecting the telomeric regions of the ge...

BRCA1 causes ovarian cancer through indirect, biochemical route

...ition, once the chemical messenger that's affected has been identified, it will be much easier to diagnose a predisposition to ovarian cancer or pinpoint just who is at risk, simply by measuring the chemical's levels. "The consequence of this finding," Dubeau says, "is that ovarian cancer is the result ...

Scientists decipher genome of fungus that can cause life-threatening infections

In a project that already has benefited animportant field of biomedical research...mans, afungus whose importance as a human pathogen has risen in parallel withthe HIV/AIDS worldwide epidemic and the increased use ofimmunosuppressive ther...

Needling Chromosomes Reveals Cell Division Secret

...of a human hair, a Duke Universitygraduate student has tested their "stickiness" to one another duringcell division. Her uncanny surgical skills have added a piece to thelarge and intricate puzzle of how one cell divides into two -- aprocess fundamental to all organisms.In the Dec. 14, 2004, issue of Cur...

Poplar trees redirect resources in response to simulated attack

...help the plant spring back to life once the attack has passed. Using the techniques developed at Brookhav...s are only just beginning to realize that isoprene has a vital role as an antioxidant in helping plants tolerate many different stresses, for example from ...

Purdue proves concept of using nano-materials for drug discovery

...hat's unique about this device is that the surface has nanometer-scale pores in it," Lee said. "The concept is fairly simple - there is an inorganic porous membrane - in this case alumina, which separates the reaction chamber from a solution. The pores in this membrane are nanometer in scale, so they do ...

In the sea slug's defense against lobsters, confusion is key

...s are not well understood by researchers. New work has now shown that such chemical defenses can involve modes of trickery that had not previously been appreciated as components of chemical defense. When attacked by predatory spiny lobsters, sea slugs (also known as sea hares) release an inky secretion,...

Researchers identify target for cancer drugs

...on and survival. Abnormally high activation of Akt has long been implicated in a variety of cancers. If A... Akt switches on when it reaches the cell membrane has only been partially understood. As a result, researchers have lacked a clear idea about how to preve...

Plant hemoglobins: Oxygen handlers critical for nitrogen fixation

...il now the physiological role of plant hemoglobins has been unclear. A group of researchers reveal this week that one such mysterious plant hemoglobin serves to assist in the fixation of nitrogen in the root nodules of legumes through a process that is conceptually not unlike that undertaken by mammalian...

Scientists rid stem cell culture of key animal cells

...lt was that "the cells looked perfect." Xu says he has grown the resulting stem cells in the desired undifferentiated state for almost a year. Although the new work "dramatically reduces the possibility of contamination" from animal pathogens, Xu warns that the continued use of serum replacement and Mat...

Essential mangrove forest threatened by cryptic ecological degradation

The recent killer tsunami has highlighted once more the importance of coastline ...international team led by Dr. Farid Dahdouh-Guebas has demonstrated that in the recent past an increase in human-environment interactions that affect the h...

Experiments provide proof of how traveling in groups protects insects

...mile or so a day. Why such groups of insects form has mystified humans for thousands of years. One firml...n for their sins. A more recent, scientific theory has been the "safety-in-numbers" idea -- that the small animals congregate periodically as a way of prot...

Protein Packages Found To Activate Genes; May Be What Regulates Development And Disease

...ing tumors. Technological breakthrough Bernstein has been studying chromosome wrappings for five years ...e with "road") Institute. "The human genome still has many surprises lurking within it," comments Lander, who is director of the institute. "One of the mo...

First 'atlas' of key brain genes could speed research on cancer, neurological diseases

..., known as the Mahoney Transcription Factor Atlas, has beenplaced online where it is freely accessible to... where tumors called medulloblastomas occur,and Ma has identified TF’s that regulate the nerves involved in thesensation of specific types of pain. Ma’s la...

Vital step in cellular migration described by UCSD medical researchers

... the body's immune response to invading pathogens, has been demonstrated by researchers in the University of California, San Diego (UCSD) School of Medicine. Published in the March 27 online edition of Nature Cell Biology and the journal's upcoming April print edition, the study describes how a the inter...

U-M scientists find genes that control growth of common skin cancer

...inhibition ofthe Hedgehog pathway. The new finding has important implications forthe treatment of this wi...key role in normal development,and its dysfunction has been implicated in a number of different humandiseases and neoplasms, including BCCs in skin and can...

Weill Cornell Research Reveals Secrets Of Trafficking Within Cells

...he cell interior. Previous work at Dr. Ryan's lab has helped clarify the role of some of the key players in this process, including a ubiquitous protein called clathrin, found in nearly every cell type. "From our previous work in brain synapses, we've learned that endocytosis is a machine that really r...

Experiments provide proof of how traveling in groups protects insects

...mile or so a day. Why such groups of insects form has mystified humans for thousands of years. One firml...n for their sins. A more recent, scientific theory has been the "safety-in-numbers" idea -- that the small animals congregate periodically as a way of prot...

New Study from Affymetrix Laboratories Points to Changing View of How Genome Works

...n of every cell in the body. Most disease research has focused on studying these protein-coding genes, ev... depth scan of 10 chromosomes; however, Affymetrix has developed tiling microarrays that cover all human chromosomes. GeneChip tiling microarrays have been...

First-ever Compounds To Target Only Metastatic Cells Are Highly Effective Against Breast, Prostate, And Colon Cancers

... idea of targeting cell migration -- metastasis -- has become an alternative strategy that's gained a lot of interest among researchers." If compounds could be found that slowed or halted cancer spread, doctors could gain valuable time in shrinking the primary tumor. "If we had the luxury of time, we co...

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