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Gene therapy converts dead bone graft to new, living tissue

...alled osteoblasts, rebuilds the bone when the body has excess calcium. In an average year, a healthy pers...e years. The Musculoskeletal Transplant Foundation has been trying for two decades to conquer the issues complicating bone transplants, and the group has p...

Antibiotic Resistant Bacterium Uses Sonar-like Strategy to “See?Enemies or Prey

...he toxinappropriately.?Gilmore says this discovery has several significant implications forthe future. “This is a new mechanism that nature devised to ‘see?theenvironment, and based on that information, respond accordingly. We maybe able to learn from nature and adapt a similar strategy to help theaging ...

Researchers reveal the infectious impact of salmon farms on wild salmon

...me reproductive," says Volpe. "In effect, the farm has exported its lice generating properties ?a cyclical event establishing the potential for re-infections up and down the coast. As the abundance of lice increases, we are now realizing that lice will attack other species, not only salmon, but other fis...

Molecular machine may lead to new drugs to combat human diseases

...nique capability of cutting and pasting apparently has been conserved since life evolved. "It's thought ...viously, and the targeted trans-splicing technique has been used to repair hemoglobin infected with sickle cell anemia. The new structure provides scientis...

Jefferson Virologists Coax HIV Out of Hiding

...found a new population, anew reservoir of HIV that has not been seen before. It’s probably asub-population of blood cells, lymphocytes not stimulated by IL-2 orOKT3. There could be other reservoirs as well.?Ultimately, he says, the answer to the latency problem may entail usinga combination of drugs. “We...

Novel Therapy Tested in Mice Could Chase Away Cat Allergies

...mice that were not allergic to cats. The molecule has the potential to prevent allergic reactions long after injections cease, Dr. Saxon says. However, further research and clinical testing would be required before it might be used in humans. He also is interested in applying this approach to develop a ...

Color-blind method opens new doors in DNA sequencing

...is technology filed a patent on PME in 2001, which has been exclusively licensed to LaserGen for commercial development. Others who participated in the research include Carter Kittrell, Bruce R. Johnson, Freddy Nguyen, Daniel A. Heller, Matthew J. Allen, Robert R. MacGregor, C. Scott Berger, Lori A. Bur...

Clam embryo study shows pollutant mixture adversely affects nerve cell development

...scientist at the Marine BiologicalLaboratory (MBL) has published the results of an EPA-funded clam embryostudy that supports her hypothesis that, when combined, the pollutantsbromoform, chloroform, and tetrachloroethylene--a chemical cocktailknown as BCE--can act synergistically to alter a key regulator ...

Yale Scientists Find MicroRNA Regulates Ras Cancer Gene

...istant Professor Frank J. Slack at Yale University has identified a new way that a familiar gene is regul...able causes in some forms of lung cancer. His team has identified let-7, a natural and separately transcribed RNA that maps to a chromosomal region associa...

Study identifies predictors of HIV drug resistance in patients beginning triple therapy

...scientist at the Marine BiologicalLaboratory (MBL) has published the results of an EPA-funded clam embryostudy that supports her hypothesis that, when combined, the pollutantsbromoform, chloroform, and tetrachloroethylene--a chemical cocktailknown as BCE--can act synergistically to alter a key regulator ...

Mouse brain tumors mimic those in human genetic disorder

...eenin children with NF1, and studying those tumors has helped usunderstand the cellular events involved in NF1 brain tumordevelopment," says principal investigator David H. Gutmann, M.D.,Ph.D., the Donald O. Schnuck Family Professor of Neurology.The study appears online and will be published in the Janua...

Automatic extraction of gene/protein biological functions from biomedical text

... various types of information from biomedical text has become critical. Since automatic functional annota...of information related to gene functions from text has been increasing. Results: We have developed a method for automatically extracting the biological pr...

New Clues Add 40,000 Years to Age of Human Species

...n the history of the Turkana Basin, a setting that has provided so much important evidence regarding huma...al Geographic Society, the age of the Omo hominids has become somewhat more controversial, and more critical, to understanding the dawn of Homo sapiens. ...

A bacterial genome reveals new targets to combat infectious disease

...inst nematode infection. Since no new antifilarial has been developed in two decades, these results may quickly lead to new therapeutic strategies against these parasites. ### Citation: Foster J, Ganatra M, Kamal I, Ware J, Makarova K, et al. (2005) The Wolbachia genome of Brugia malayi: Endosymbiont e...

Spider Venom Could Yield Eco-Friendly Insecticides

... as a panacea. But widespread use of the chemicals has boosted insects' resistance, even to increased dos...systems into overdrive. King's NSF-funded research has provided the first detailed descriptions of the regions of the toxins that are essential for interac...

New imaging method gives early indication if brain cancer therapy is effective, U-M study shows

...ing to the chemotherapy or radiation therapy. This has potential to spare patients from weeks of a grueling treatment regimen that's not working and gives doctors the opportunity to switch patients early on to a therapy that may be more effective. Results of the study appear the week of March 28 in the ...

Gene variations explain drug dose required to control seizures

...t doses of both carbamazepine and phenytoin. SCN1A has been implicated in many inherited forms of epilepsy and is the drug target for phenytoin. Given its relationship to both anti-epileptic drugs tested, the SCN1A variant may be of particular importance for understanding patient response to drug treatm...

Solution to Pollution: New Bacteria Eats Toxic Waste

...t these carcinogens in our environment, and nature has figured out a way to cleanse herself. We want to be able to understand it better through genomic analysis.?/p> Engineers often use other human-made chemicals to clean up contaminated sites, but these microbes will provide a natural solution, sai...

Scientists collaborate to assess health of global environment

For the first time, a group of scientists has accomplished the daunting task of evaluating the s...ber, timber, fresh water, fuel and other resources has begun to jeopardize more subtle services that nature has always provided free of charge, he said. Ma...

Muscle-targeted gene therapy reverses rare muscular dystrophy in mice

...on of a large amount of the enzyme. "Gene therapy has the potential to reverse the course of the disease with a single treatment," Koeberl said. The researchers delivered the glycogen-degrading enzyme with an adeno-associated virus (AAV) vector. AAV is not associated with any known human disease. The D...

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