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Tag: "has" at biology news

It's not all genetic: Common epigenetic problem doubles cancer risk in mice

...cientists from the United States, Sweden and Japan has discovered that having a double dose of one protein is sufficient to change the normal balance of cells within the lining of the colon, thereby doubling the risk that a cancer-causing genetic mutation will trigger a tumor there. Roughly 10 percent of...

Dysentery uses 'sword and shield' to cause infection

...or dysentery. In this case, the dysentery bacteria has evolved into a highly effective and dangerous infection." ...

Novel technology detects human DNA mutations

...determine if either of the bases is mutated (i.e., has SNPs). Nanosphere's technology can rapidly, easily, and accurately interrogate both bases in the pair to determine if they are homozygous (i.e., both are mutant or normal) or heterozygous (i.e., one is mutant, one is normal) ?the most critical step i...

Priming embryonic stem cells to fulfill their promise

...olding, of most mammalian tissues. Untilnow, there has been no practical way to evaluate the daunting num...all the combinationsat once," said Bhatia. "Nobody has done this combinatorial approachbefore."Bhatia, Chien, and Flaim reported that either collagen-1 or ...

Growth in the sea comes down to a struggle for iron

...b-Arctic Pacific," says Wells. "The North Atlantic has a big spring bloom, just like we have on our coast...rily at understanding these natural systems, there has been some speculation that iron fertilization might be useful in reducing the threat of global warmi...

New, automated tool successfully classifies and relates proteins in unprecedented way

...ively andwithout error," Murphy said.Murphy's tool has two key components. One is a set of subcellularlocation features (SLFs) that describe a protein's location in a cellimage. SLFs measure both simple and complex aspects of proteins, suchas shape, texture, edge qualities and contrast against background...

New binding target for oncogenic viral protein

...cker emphasized. "The study of DNA tumors viruses has been an extremely important tool in understanding the cellular pathways that regulate cell division and are disrupted in cancer. Understanding the mechanisms through which these viruses interact with the cellular machinery that regulates cell divisio...

Lack of enzyme turns fat cells into fat burners

...nd his colleagues have demonstrated the effectACC2 has on mice. Mice bred to lack the enzyme can eat a high fat, highcarbohydrate diet without gaining weight, while their normalcounterparts become obese and develop type 2 diabetes."This adds another tissue or organ that helps out in the process ofenergy ...

Poor prenatal nutrition permanently damages function of insulin-producing cells in the pancreas

...good predictors of human biology, the Joslin study has important implications. "People and their doctors need to understand that prenatal undernourishment makes a person permanently at higher risk for developing diabetes, so prenatal care is important," Dr. Patti said. "Moreover, if someone was born with...

Fox Chase Cancer Center scientists identify immune-system mutation

...ists led by immunologist Dietmar J. Kappes, Ph.D., has identified the genetic mutation that keeps a mouse...cond time that a naturally occurring mutant strain has been found and bred at Fox Chase. In 1981, the laboratory group of Melvin Bosma, Ph.D., discovered m...

Controversial drug shown to act on brain protein to cut alcohol use

... by some clinicians as apotent anti-addiction drug has been rigorously studied for the firsttime, confirm...ction. Derivedfrom a West African shrub, Ibogaine has been championed for years by acadre of clinicians and drug treatment advocates impressed with itsabi...

Neuronal 'traffic jam' marks early Alzheimer's disease

...ollege of Medicine. According to Goldstein, there has been evidence that late-stage Alzheimer's disease involves a failure of the machinery that transports proteins within neurons. In studies with fruit flies, Goldstein and others had observed that overexpression of the gene for a key protein that under...

Current human embryonic stem cell lines contaminated UCSD/Salk team finds

...cult to completelyeliminate the Neu5Gc, because is has become metabolically incorporatedinto the currentl...l products for deriving human embryonic stem cells has become morespecific, being defined in molecular terms," Varki said."Such issues will, of course, bec...

Mouse brain cells rapidly recover after Alzheimer's plaques are cleared

...ve cells' rapid ability to regain normal structure has Holtzmanand Brendza wondering if the nerve cells are constantly trying torestore their normal structure. If so, that recuperative effort mustsomehow be countered on an ongoing basis by the effects of the plaques.More research is needed to determine i...

Genome of deadly amoeba shows surprising complexity, evidence of lateral gene transfer

...nificance is not yet known. "Clearly, this amoeba has genes that allow it to sense certain facets of its...from re-infection. Says Petri: "The genome project has spawned rapid discovery of the parasite's mechanisms for replication, gene expression, motility, met...

Key molecule in plant photo-protection identified

...ve cells' rapid ability to regain normal structure has Holtzmanand Brendza wondering if the nerve cells are constantly trying torestore their normal structure. If so, that recuperative effort mustsomehow be countered on an ongoing basis by the effects of the plaques.More research is needed to determine i...

Antarctic ice shelf retreats happened before

...ir temperatures can break up ice shelves but there has been a suspicion for some time that the role of th...ce shelf didn't reform until 1500 years later, and has been present ever since. The findings are particularly relevant for other studies on the West Antar...

Anti-bacterial additive widespread in U.S. waterways

...choolof Public Health. The chemical, triclocarban, has been widely used fordecades in hand soaps and othe...tentialbioaccumulation. Triclocarban, for example, has an estimated half lifeof 1.5 years in aquatic sediments. Do the potential benefits ofantimicrobial p...

Newly-discovered class of genes determines ?and restricts ?stem cell fate

...Understanding the molecular control of these genes has implications for therapies that involve tissue regeneration. The researchers found that Pax3, a gene critical in embryonic development of melanocytes ?cells that make and store the pigments in the skin and hair ?is also expressed in adult stem cells...

Timing is everything: First step in protein building revealed

... inscience. A team led by Johns Hopkins scientists has unraveled the firststep in translating genetic inf...egulates the ribosome's activity.The research team has demonstrated that eIF1's mere presence on theyeast ribosome prevents the machinery from getting star...

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