Fibril Shape Is The Basis Of Prion Strains And Cross-species Prion Infection
...f mouse fibrils emerged with the ability to infect hamsters but not humans. The new mouse strain had the same amino acid sequence as the original mouse strain but completely different infectious capabilities. With the help of atomic-level microscopic observation of prions in humans, mice, and hamsters, Jones...Strongest proof yet found for prion hypothesis
...ty of a small number of prions taken from infected hamsters and placed in test tubes containing healthy brain proteins. When the healthy proteins had been largely transformed into prions, the samples were diluted over and over again and the process repeated, until the only remaining prions were those that had...Unweaving amyloid fibers to solve prion puzzles
...notes: "In fact, some type of prions from infected hamsters can't make the species jump into mice, while others do, and vice versa." While the results of this research are clearly of interest to scientists investigating conditions such as Alzheimer's, it's also relevant to scientists studying nanotechnology....Gene therapy reverses genetic mutation responsible for heart failure in muscular dystrophy
...mb girdle"-- as well as in the heart. Like humans, hamsters with this particular delta-sarcoglycan gene defect...ng muscle cells in both newborn- and adult-treated hamsters were able to express the normal protein almost a year later. There were dramatic biochemical and str...Animal models show that anabolic steroids flip the adolescent brain's switch for aggression
...sity in Boston, the current study of 76 adolescent hamsters compared how individual hamsters behaved when another hamster was put into their cages. Normally mild-mannered hamsters still defend...New brain hormone puts brakes on reproduction
... stimulates GnRH. The discovery in rats, mice and hamsters of this new system for regulating reproduction strongly suggests that the hormone plays a similar role in the reproductive systems of humans and other mammals. The human genome, in fact, contains a gene for GnIH. If the new finding is mirrored in hu...Prion find points way to test for human 'mad cow' disease
... in cattle and vCJD in humans--in the blood of the hamsters in as few as 20 days after the animals had been in...t discovery occurred about three months before the hamsters began showing clinical symptoms of the disease, the Science paper reports. To detect the very small...Just like us, social stress prompts hamsters to overeat, gain weight
...Neuroscience at Georgia State University are using hamsters as a model for human stress-induced obesity. They ...ores. They set up a situation in which subordinate hamsters would suffer a "social defeat" at the hands of a dominant hamster. The researchers wanted to see if ...Bacterial protein shows promise in treating intestinal parasites
...s thuringiensis, or Bt, given orally to laboratory hamsters infected with hookworms was as effective in elimin...es, curing anemia and restoring weight gain in the hamsters as mebendazole, one of the drugs currently recommended to treat infections in humans. The scientists...Adolescent but not adult hamsters are more aggressive on low dose of fluoxetine
... University of Texas at Austin found that juvenile hamsters given low doses of fluoxetine hydrochloride, which...udy, researchers injected each of the experimental hamsters with high or low doses of fluoxetine. Two hours later, they put a smaller, younger same-sex hamster...MIT material stops bleeding in seconds
...onstriction and sponges. In their experiments on hamsters and rats, the MIT and HKU researchers applied the ...ilar liquid was able to partially restore sight in hamsters that had had their visual tract severed. In that case, the self-assembling peptides served as an int...Active ingredient in common Chinese herb shown to reduce hypertension
...to constrict the right renal artery. Sham-operated hamsters and mice underwent the same procedure, except for the placement of a clip. Both sets of hamsters received 50 ¦Ìg of tanshinone IIA/100g of body weight once a day for two weeks. After the two-week t...