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Tag: "halting" at biology news

Fox Chase Cancer Center scientists identify immune-system mutation

...nces in stimulating desirable immune responses and halting undesirable immune reactions, Kappes said. This understanding can further progress against various immune disorders, allergies and certain cancers, such as those of the blood and bone marrow, that involve a compromised immune system. "As one example...

Cerebral navigation: How do nerve fibers know what direction to grow in?

... collapse, steering the axon in a new direction or halting its growth. In chicken motor neurons whose ephexin1 was inactivated, the axons grew into the hind limb prematurely, indicating faulty axon guidance. "Understanding these pathways could help in understanding the process of nerve regeneration," says G...

Fox Chase study shows that weakened T-cell receptor signals change T-cell lineage

...nces in stimulating desirable immune responses and halting unwanted ones. "Although their precise function is still unclear, delta-gamma T cells seem to form the first line of response against external disease-causing agents, including bacterial infections, tissue damage and stress," Wiest said. "Laboratory...

Rabies spread speeds up

...pread, Real and colleagues make a strong case that halting its western march depends on a strategy based on early detection and high-powered intervention programs - a sensible approach for any infectious disease. ### Citation: Russell CA, Smith DL, Childs JE, Real LA (2005) Predictive spatial dynamics and ...

Cancer related gene p53 not regulated as indicated by previous tissue culture research

...vation. Instead of accumulating in mouse cells and halting cell division in the genetically engineered mice, the altered p53 protein performed flawlessly: it was unstable when no DNA damage was present and was stable and fully functional when needed to halt the cycle cell to repair DNA damage or to induce ap...

'Genetic network' guards against lethal DNA damage

...genes involved in DNA repair, DNA replication, the halting of replication and cell cycle progression by "checkpoints" so that damaged DNA can undergo repair, and responses to oxidative stress necessary for reducing the intracellular levels of highly reactive molecules that bind to and damage DNA. The yeast ...

Engineered heart tissue offers insights into irregular heartbeats, defibrillator failure

...een those that responded to pace-setting shocks by halting their aberrant rhythm, and those that responded by...d to more reliable and less painful strategies for halting arrhythmias, Bursac said. For example, preliminary observations suggested that pacing the engineered...

Mayo Clinic researchers discover cancer cells may move via wave stimulation

...ding this process is the first step toward one day halting it, preventing it or reversing it therapeutically." Why Movement Matters Cell growth and movement are vital topics in cancer research because cancer is a disease of uncontrolled cell growth in which the normal balance between growth promotion and g...

First human study confirms that immune cells can be a primary cause of bone loss in gum disease

...gues hope to determine methods for intervening and halting bone loss and thus improving the health outcomes of the estimated 80 million Americans suffering from periodontal disease. The study, led by Toshihisa Kawai, D.D.S., Ph.D., examined whether immune response to periodontal bacteria is protective or p...

FSU biologists uncover mechanisms that shape cells for better or worse

...yte acts to turn off a gene known as Dystroglycan, halting production of its protein. EGFR must shut down Dystroglycan in order for the oocyte to properly polarize," Poulton said. "We proved this by observing that mutated forms of genes in the EGFR pathway of cells surrounding the oocyte led to abnormally ...

Researchers seek to solve mystery of natural HIV control

...that ability in others, we would have a recipe for halting the HIV epidemic," says Bruce Walker, MD, director of Partners AIDS Research Center (PARC) at Massachusetts General Hospital and an initial organizer of the Elite Controller Collaborative Study. Walker discussed the project in a media briefing today...

Think fast! Rice undergrad unlocks nerve speed secret

...e neuronal cell ?was inhibited by complexin. "By halting fusion partway, complexin essentially shortens the response time for signal transmission," said Schaub, who will begin graduate school at Stanford University in the fall. "The nerve cell can almost instantaneously pass on its information." McNew sa...

Gene screen for breast cancer better than pathologist's 'eye'

...ls of methylation, which turns the gene switch off halting the assembly line of critical proteins found in normal cells. The Hopkins test, called quantitative multiplex methylation-specific PCR or QM-MSP, determines the percentage of methylation present in each of five to ten cancer genes. The percentages...

Gene therapy injected into the brains' of mice with Huntington's disease

...altered the natural course of disease, potentially halting it, we would hope every potential patient would get tested so they could avail themselves to the therapy." Researchers used a defective virus, adenoassociated viral vector, (AAV) to deliver gene therapy (glial-derived neurotrophic factor (GDNF) dire...

Lack of key enzyme associated with development of rare tumor

...he enzyme is one of a class of enzymes involved in halting a cell's response to hormones and appears to stop ...iesterases degrade the cyclic nucleotides, thereby halting the cell's response to the hormone. In the study, the patients' tumors were made up of cells that w...

'LEGO-Like' building blocks to halt cell growth wins Hebrew University prize

...activation of the IGF-1 protein in the cells, thus halting the cancerous growth. Through this process of "combinational chemistry," involving peptides and scaffold design, Qvit says that many different types of molecules can be built that will reach specifically targeted cells, offering hope for treatment ...

Mouse study reveals new clues about virulence of 1918 influenza virus

...elop new or improved agents aimed at moderating or halting the human immune system's overactive response to these viruses. ...

Solved: The mystery of flesh-eating bacteria's relentless attack

... strategies for treating necrotizing fasciitis and halting its rapid destruction of tissue. The paper was published in advance online. The bacterium, group A Streptococcus, wreaks destruction on muscle and skin tissue in the form of necrotizing fasciitis, which kills roughly 30 percent of its victims and l...

Jefferson scientists find aging gene also protects against prostate cancer development

...py and showed that SIRT1 blocks receptor activity, halting cancer growth. “We systematically tested each androgen receptor mutation,?Dr. Pestell explains. “These mutant receptors are resistant to current therapies and are all blocked by expression of SIRT1,?adding that prostate specific antigen (PSA) levels ...

Gene chip technology shows potential for identifying life-threatening blood infection

...hin days. With a narrow window of opportunity for halting its lethal spread, doctors who suspect sepsis typically rush to prescribe powerful antibiotics, even before laboratory tests can confirm the diagnosis. But this practice invariably leads to the inappropriate treatment of many patients who have life-t...

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