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A gene's first 'kiss' sets off that affair known as puberty

...l Academy of Sciences (PNAS). Until now, little had been known about what instigates the cascade of ho...earn about KiSS-1, which in earlier rodent studies had been identified as a molecule that activates a signal receptor of GPR54, the researchers looked to t...

Chemists create 'Superbowl' molecule; May lead to better health

...nd viral behavior. Until now, these molecules have had a very limited carrying capacity. "The compounds we made are bigger versions of these original bowl molecules," says study leader Michael Sherburn, Ph.D., a chemist with Australian National University in Canberra. "These new molecules have much grea...

Wisconsin scientists grow critical nerve cells

...cientists for decades. One reason scientists have had difficulty making motor neurons, Zhang believes, may be that they are one of the earliest neural structures to emerge in a developing embryo. With the ticking clock of development in mind, Zhang and his team deduced that there is only a thin sliver o...

Man and mouse share genome structures

...tarting points of active genes, as they and others had seen earlier in the yeast. Unexpectedly, they also found tags idling over regions near genes. The researchers think these sites have important regulatory functions, because the methylation patterns are similar in comparable portions of the mouse geno...

Deficient DNA Repair Capacity Associated With Increased Risk Of Breast Cancer

...es taken from pairs of sisters in which one sister had been diagnosed with breast cancer and the other had not. They found that DNA repair capacity was lower in breast cancer patients than in the control su...

Quantum Dots Research Leads to New Knowledge about Protein Binding in Plants

...zinc sulphide as fluorescent probes. The particles had adiameter of 6.3 nm. The team terminated the quantum dots withcarboxylic groups by reacting them with mercaptoacetic acid. Then theyconjugated the quantum dots with the amine groups of stigma/stylarcysteine-rich adhesin (SCA) - a plant pollen tube ad...

W.M. Keck Foundation funds study of friendly microbes

...w us with key metabolic functions that we have not had to evolve on our own," Gordon says. He and his colleagues have used mouse models of the human gut ecosystem to show that intestinal bacteria allow calories to be harvested from otherwise indigestible components of the diet, such as polysaccharides. ...

Yellowstone microbes fueled by hydrogen, according to U. of Colorado study

...e of which hadnever before been collected. "No one had measured the concentration ofhydrogen in the hot s...d during different seasons. All of theenvironments had concentrations appropriate for energy metabolism.The team used computer-generated thermodynamic mode...

It's not all genetic: Common epigenetic problem doubles cancer risk in mice

...t." Because precursor cells in the colon's lining had been identified as a likely starting point for tum...ce carrying a mutation in a gene called APC, which had been tied to colon cancer by researchers studying families with excessive growths, or polyps, in the...

Priming embryonic stem cells to fulfill their promise

...her it'scells in the liver, brain, or heart, there had been no practical wayfor researchers to find the optimal extracellular matrix needed to turnembryonic stem cells into cells with therapeutic potential," saidBhatia. "We think we've developed an enabling technology for stem cellresearch and other area...

Growth in the sea comes down to a struggle for iron

...irst SEEDS experiment in 2001. Japanese scientists had recorded the largest phytoplankton bloom of any of...ion in the northwestern Pacific, the Japanese team had already injected iron into the water and were monitoring the growing phytoplankton patch, roughly si...

Poor prenatal nutrition permanently damages function of insulin-producing cells in the pancreas

...third week, restricted to only half the amount. It had a dramatic effect. At birth, their babies weighed ...weaned, at three weeks, the low-birth-weight group had caught up with the others, something we see in human babies too," said Dr. Patti. "They looked and a...

Emory Study Tests Bone Marrow Stem Cells to Improve Circulation in Legs

...row to release stem cells; andin patients who have had a bone marrow transplant to increase thenumber of white blood cells. It is still considered experimental,however, for use to increase the level of EPCs in patients withperipheral vascular disease.The investigators are seeking patients in whom prior t...

Neuronal 'traffic jam' marks early Alzheimer's disease

... In studies with fruit flies, Goldstein and others had observed that overexpression of the gene for a key...t," said Goldstein. The researchers used mice that had been engineered to have an abnormal production of human A-beta peptide that produced Alzheimer's-lik...

Termites feed through good vibrations

... blocks and the scientists found that the termites had no preference for either large or small blocks. Br...e signal from the termites feeding on large blocks had this characteristic frequency plus other signals indicating the presence of other termites in that "...

Current human embryonic stem cell lines contaminated UCSD/Salk team finds

...the cell surface of human embryonicstem cells that had been grown in traditional culture conditions. Thes...to10.5 percent. In human embryonic stem cells that had been allowed todifferentiate into embryoid bodies (EB), which is the first step inpreparing them for...

UCLA Study Shows One-Third of Drug Ads in Medical Journals Do Not Contain References Supporting Medical Claims

...riginal research cited in the ads was funded by or had authors affiliated with the product's manufacturer...ad references citing original research, 58 percent had research sponsored by a pharmaceutical company or had affiliated authors, 19 percent were funded by ...

Mouse brain cells rapidly recover after Alzheimer's plaques are cleared

...orations withresearchers at other institutions, he had acquired several keytechniques and technologies th...er's-like condition.The mice he used for the study had two mutations. One, utilized byscientists at Eli Lilly, causes amyloid plaques to build up, creating...

Key molecule in plant photo-protection identified

...orations withresearchers at other institutions, he had acquired several keytechniques and technologies th...er's-like condition.The mice he used for the study had two mutations. One, utilized byscientists at Eli Lilly, causes amyloid plaques to build up, creating...

Newly-discovered class of genes determines ?and restricts ?stem cell fate

...e stem cells were expressing genes that previously had only been known to be expressed in a developing embryo. That was the first clue that we were on to something new." Epstein and colleagues report their findings in the February 24th issue of Nature. The scientists found that Pax3 plays dual ?and some...

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