Human trial proves ricin vaccine safe, induces neutralizing antibodies; further tests planned
...food may require inducing immunity in the lung and gut by a very different formulation and vaccination schedule. Depending on how the ricin is administered as a poison, victims develop fever, nausea and abdominal pain or lung damage before dying within a few days of exposure. There is no antidote after ...Plants give pests sock in the gut
...itrophic matrix. This is a membrane that lines the gut of most insects and aids digestion. It also protects the insects from being invaded by microorganisms and parasites through the food they eat. At the heart of the matrix is a protein called the insect intestinal mucin, or IIM. It is very similar to...New evidence questions the simple link between prion proteins and madcow disease
... addition, the results show that the places in the gut that do take up these disease-associated proteins ...d by blocking uptake of abnormal proteins from the gut ?it must be achieved by some other mechanism," says lead author Dr Martin Jeffrey. Secondly, they l...Study fishes out new role for prostaglandins
...p ?the innermost layer (endoderm), which forms the gut and associated digestive organs; the middle layer (mesoderm), which develops into muscle, bone and cardiovascular organs, and the outer layer (ectoderm), which becomes the skin and nervous system. "The body is a tube in a tube in a shell," Solnica-...Bone marrow cells can become functional gut lining cells
...ough this is exciting, the levels of donor derived gut cells are currently far too low to be used as a treatment for cystic fibrosis, an inherited disease in which the organs, especially those of the pancreas, lungs, and intestines, become clogged with thick mucus. "We hope this finding will have implic...... Williams. "We know there are major differences in gut structure and digestive enzymes between non-migrating and migrating birds, so there might also be similar alterations in migrating bird's physiology further north, which allow more efficient digestion." ...UC Davis study finds HIV hiding from drugs in gut, preventing immune recovery
... also found that HIV continues to replicate in the gut mucosa, suppressing immune function in patients be...lls in peripheral blood, it is not so effective in gut mucosa," said Satya Dandekar, professor and chair of the Department of Medical Microbiology and Immu...Recombination protein dynamics observed with single monomer resolution
... RecA is a DNA recombination protein found in the gut bacterium E. coli. A human homolog, called Rad51, interacts with many proteins, including BRCA2, whose mutation increases susceptibility to breast and ovarian cancers. A better understanding of how these proteins function could help our understanding...Gut microbes' partnership helps body extract energy from food, store it as fat
... between members of our vast community of friendly gut microorganisms have shown that two common organism...m-free mice, colonization with two prominent human gut microbes led to fatter mice. Scientists at Washington University School of Medicine in St. Louis cal...Parallel evolution: Proteins do it, too
...gestive system similar to a cow's. Bacteria in the gut ferment the leaves and take up nutrients that are released in the process. The monkeys, in turn, digest the bacteria to recover the nutrients, such as protein and ribonucleic acid (RNA), a particularly important source of nitrogen in leaf eaters. Zh...OHSU study says stem cell 'fusion' occurs in tumors
...u eat, that can induce mutations in the cells. The gut protects itself by rapidly turning over its epithelial cells. Plus, when there is damage to the surface lining, it is critical that regeneration and reestablishment of the barrier occurs rapidly. We think that cell fusion with bone marrow cells is th...'Molecular assassin' targets disease gene
...sed blood vessels, eyes, lungs, joints, and in the gut ?in any number of areas involving inflammation and aggressive vascular growth. "Our experimental drug, Dz13, is like a secret agent that finds its target, c-Jun, within the cell and destroys it," he said. "It is a specific, pre-programmed 'molecula...Gut reaction: Researchers define the colon's genome
...ers used two strategies. First, they matched their gut microbial DNA sequences up to two databases, one c...culled sequences to two previously sequenced human gut organisms: a bacterium, Bifidobacterium longum , and the archaeal microbe M. smithii . These known...Most widely used organic pesticide requires help to kill
...acillus thuringiensis is facilitated by the normal gut community," says Nichole Broderick, a UW-Madison g...ple, have anywhere from seven to twenty species of gut bacteria. Humans have between five hundred and one thousand species of micro flora that take up resi...A new understanding of how cells defend themselves against bacterial pore-forming toxins
...cused on epithelial cells, the cells that line the gut and blood vessels. Van der Goot explains that because they form a protective layer, it's critical for the organism that these cells survive, even if they don't function correctly. If the cell dies, it leaves the underlying tissue exposed. She hypothe...Malaria vaccine prompts victims' immune system to eliminate parasite from mosquitoes
...gut, after which the parasite imbeds itself in the gut lining. There, it passes through discrete stages, before migrating to the insect's salivary glands, where it is passed on to the next host through a mosquito bite. The protein Pfs25 (Plasmodium falciparum surface protein 25) is found only on the...Dragonfly's metabolic disease provides clues about human obesity
...ess, which may be a sign that fructose affects the gut microbial flora," said Marden. Another clue is ...disease should test the hypothesis that changes in gut microbial composition can cause these syndromes." __IMAGE_3 Marden's lab, which studies how in...Worms produce surprise insight into human fever
...r?strategies against hostile bugs peristalsis, low gut pH, lytic enzymes, and antimicrobial peptides to prevent microbial colonization of the intestine. In dissecting two conserved pathways required for C. elegans immunity to bacteria, Aballay found a wealth of data on innate immunity plus a surpri...The biggest bug in gut discomfort
...ull-scale invasion of millions of cells lining the gut can’t be ignored. ...Sea urchin genome suprisingly similar to man and may hold key to cures
... just one gene expression of a single-cell layered gut of the sea urchin larva, at least 14 proteins binding the DNA at 50 sites are needed, Calestani said. "Multiply that hundreds of times and you begin to understand the level of complexity involved in human development," she added. Using a "simpl...