Researchers discover chemical compounds that affect plant growth
... the ability of plants to alter their direction of growth in response to gravity, a phenomenon known as grav...219 chemicals that affected the direction of plant growth due to gravity. Further screens reduced this number to 34, then down to 4 chemicals, which affected ...New component of the 'brakes' on nerve regeneration found
... myelin. Specifically, these molecules prevent the growth of the cablelike axons of injured neurons. Myelin is the fatty sheath that encases neurons and acts as an insulator and aid to the transmission of nerve impulses. Researchers knew that CNS neurons had receptors on their surface that accepted the inh...Stopping smallpox in its tracks: A new anti-viral approach
...ht inhibitor of signaling mediated by the smallpox growth factor (SPGF). SPGF targets the erbB-1 signaling molecule, which normally initiates an intracellular cascade that facilitates viral replication. This study shows that drugs that interfere with erbB-1 signaling inhibit SPGF-induced viral replication...Scientists discover how plants disarm the toxic effects of excessive sunlight
... it is often used as a host defense to inhibit the growth of unwanted microbial pathogens. In fact, it appears that even non-photosynthetic bacteria, including human and animal pathogens like Vibrio and Pseudomonads have systems to sense and protect themselves from singlet oxygen, says Donohue. Other reacti...Single stem cells from bone heal a broken heart
...c function because the cells stimulated release of growth factors and anti-apoptotic agents that, in turn, increased the proliferative potential of cardiomyocytes and enhanced survival of host myocardium. This is the first report of endogenous cardiomyogenesis after adult human stem cell transplantation. M...HIV-1 spread through six transmission lines in the UK
...al therapy has not had a significant impact on the growth of the epidemic and that changes in sexual behavio...-mid 1980s. After an initial period of exponential growth in infection rates, the spread generally slowed in the early 1990s, more likely from changes in sexu...Gene therapy promising for growing tooth-supporting bone
...ichigan research team has found that introducing a growth factor protein into a mouth wound using gene thera... rats in an attempt to turn on the body's own bone growth mechanisms. The study showed that animals that got the BMP-7 treatment produced nearly 50 percent mo...New drug shows promise as powerful anticancer agent
...ned the effects of Plk1 inhibitor ON01910 on tumor growth in several animal models. The researchers found that ON01910 arrests cell division in a variety of human cancer cells, including cells that are notoriously resistant to commonly used chemotherapeutic agents. The compound significantly inhibited a wid...Alzheimer's cognitive decline slowed
... a study participant who had died and found robust growth of extensions from the dying cholinergic cells near the site of growth factor gene delivery. Cholinergic neuron loss is a cardinal feature of Alzheimer's disease, a progre...Scientists identify molecule that regulates well-known tumor suppressor
...nositol 3' kinase signaling pathway regulates cell growth and survival, and is inhibited by activity of the tumor suppressor PTEN. Research indicates that PTEN exerts its tumor suppressor activity by inhibiting PKB/Akt signaling that is critical for cell survival. Many human cancer cells exhibit mutations i...Nanoparticles offer new hope for detection and treatment
...n inch) wide. Small, rapidly growing tumors cause growth of new blood vessels, which feed the tumors. To get the particles to bind to tumors, the researchers equipped them with tiny "hooks" that link only to complementary "loops" found on cells in newly forming blood vessels. When the nanoparticles hooked ...Anti cancer virotherapy well tolerated in first human administration, research finds
... use of a common cold virus to control cancer cell growth has begun safety testing in human subjects. The research was presented to the third International Meeting on Replicating Oncolytic Virus Therapeutics, on Friday 11 March by Newcastle University associate professor, Darren Shafren. The technology is...Harmful chemicals may reprogram gene response to estrogen
...a female hormone that is involved in promoting the growth of tumors by regulating the activity of key genes involved in cell growth. "We found that the DES treatment somehow 'reprogrammed' how these genes respond to estrogen, making them much more responsive to estrogen than normal," said Walker. "We realiz...Protein That Promotes Survival Of Stem Cells Might Be Key To Poor Leukemia Prognosis
...cell types. Finally, the investigators showed that growth factors (natural proteins that stimulate cells to grow), such as the "stem cell factor," trigger the expression of the Mcl-1 gene. This was an important clue to how cells control the powerful effects of Mcl-1. Other authors of this study are Hiromi ...Researchers report new pro-inflammatory role for anti-inflammatory enzyme
...et aggregation, the reactivity of immune cells and growth of vascular smooth muscle cells," explains Dr. Hobbs. "iNOS is not expressed under normal physiological conditions, but is up-regulated for host-defense purposes." Now, the researchers have validated their hypothesis in vivo using mice that do not p......ertain conditions, the HER2 receptor amplifies the growth signal received by the cell. Yarden and Prof. Mich... thus cease signaling. In response, the cell halts growth and, when chemotherapy is used in combination with the immunotherapy, it dies. According to Sela, t...NASA study finds snow melt causes large ocean plant blooms
...aters also provide the perfect environment for the growth of a specialized group of bacteria called denitrifying bacteria. These bacteria convert a nitrogen-based nutrient readily consumable by plants in seawater, called nitrate, into forms of nitrogen that most plants cannot use. One form of nitrogen that...Genetically Modified Natural Killer Immune Cells Attack, Kill Leukemia Cells
...mes their original number. The technique triggered growth of NK cells specifically, which greatly simplified the ability of the researchers to collect a pure population of these immune cells. The researchers then genetically modified the growing NK cells so they carried on their surface an artificial recep...Nano-bumps could help repair clogged blood vessels
...al joints. The smaller features also stimulate the growth of more new bone tissue, which is critical for the proper attachment of artificial joints once they are implanted. Now the biomedical engineers have seen the same kind of increased attachment for endothelial and vascular smooth muscle cells lining t...New understanding of DNA repair may pave way to cancer treatments
... with ATF2 function, efficiently blocking melanoma growth in mouse models. Ongoing studies are devoted to sc... that the mechanism by which ATF2 affects melanoma growth was primarily through its established function in the regulation of proteins important in cell cycle...