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Tag: "grafts" at biology news

Columbia study shows widely used artery clearing device does not help patients during heart attack

...y and successfully used during angioplasty in vein grafts and stenting in carotid arteries. The study, published in the March 2 issue of the Journal of the American Medical Association, found that the devices were successful in removing debris from the arteries in angioplasties during heart attacks, but it ...

Engineered skin offers clues to melanoma development

...ficed at different time points to examine the skin grafts for signs of melanoma and to determine whether the cancer had metastasized. The researchers began by introducing several mutant genes commonly found in human melanomas. These included genes that interfere with the retinoblastoma (Rb) and p53 tumor s...

Ibruprofen and other commonly used painkillers for treating inflammation may increase the risk of heart attack

...ficed at different time points to examine the skin grafts for signs of melanoma and to determine whether the cancer had metastasized. The researchers began by introducing several mutant genes commonly found in human melanomas. These included genes that interfere with the retinoblastoma (Rb) and p53 tumor s...

Researchers use RNAi libraries to identify regulators of apoptosis and chemoresistance

...ficed at different time points to examine the skin grafts for signs of melanoma and to determine whether the cancer had metastasized. The researchers began by introducing several mutant genes commonly found in human melanomas. These included genes that interfere with the retinoblastoma (Rb) and p53 tumor s...

Stem cells' electric abilities might help their safe clinical use

...SC-based therapies is the potential for engineered grafts to go haywire after transplantation and form tumors, for instance, due to contamination by only a few undifferentiated human ESCs," says Ronald A. Li, Ph.D., an assistant professor of medicine at The Johns Hopkins University School of Medicine and se...

'Nanospheres' that block pain of sensitive teeth

... and bone and so is widely used by medics for bone grafts or dental coatings (because it binds strongly with the bone material). Earl and his colleagues grew hydroxyapatite at various pH levels to vary the size of the particles it is made up of. At normal pH, it is composed of long rod-like structures but ...

Scientists use stem cells to grow cartilage

...have to cut away parts of cartilage, and then take grafts from other parts of the body. With this new technique doctors would potentially be able to take stem cells from the patient, grow them in a laboratory, and then transplant them after the surgery. This work builds on an earlier collaboration between ...

Cells from amniotic fluid used to tissue-engineer a new trachea

...f cartilage tube, and then implanting these living grafts into the lambs while still in the womb. The trach...rentiate into cartilage cells. When the engineered grafts were ready, they were used to reconstruct defective tracheas in seven fetal lambs. Four to five week...

Plastic surgeons countdown first full facial transplantation

...hods for facial reconstruction, which include skin grafts and flaps, are reliable and effective techniques f...ilable on the body. In addition, it takes multiple grafts and surgeries to successfully reconstruct the entire face. Many patients are left with a patchy, un...

Cincinnati surgeons report new treatment for often-fatal injury

...rta and lining it with a series of small synthetic grafts (endografts) they could effectively protect the damaged area without stopping blood flow to the rest of the body. The endografts are regularly used in vascular surgery to treat aneurysms in the abdomen, Dr. Giglia explains, but they are too short t...

Microscopic scaffolding offers a 'simple' solution to treating skin injuries

...urns where surgeons are unable to take enough skin grafts from elsewhere on the body to cover the damaged areas. Currently, bovine collagen** or skin from human donors is used in these cases, but these approaches have potential health and rejection risks. "Simplicity is the key," says Professor Tony Ry...

Stanford doctors advance in bid to turn mice stem cells into blood vessels

...iovascular disease, the need for arterial vascular grafts continues to grow. In 2002, there were 1.5 million medical procedures done that required replacement blood vessels. "This is an exciting, emerging research front," said John Cook, MD, PhD, professor of medicine (cardiovascular medicine). "It has gre...

Spinal cord bridge bypasses injury to restore mobility

.... For more than 100 years, researchers have used grafts of peripheral nerves from the rib area or parts of...hile peripheral nerves can be used successfully as grafts in the limbs, spinal cord injuries put up defenses called inhibitory chondroitin sulfate proteoglyc...

Making a face: A new and earlier marker of neural crest development

...aid Martín García-Castro . The researchers grew grafts of cells from "stage 3" chick embryos, before the neural plate formed, in non-inducing cultures. Surprisingly, restricted regions of the embryo generated both migrating neural crest cells and their derivative cell types, without any interaction with ...

MIT creates 3-D scaffold for growing stem cells

...issues used in regenerative medicine, such as skin grafts or neurons to replace brain cells lost to injury or disease. The scaffold itself can be transplanted directly into the body with no ill effects. "The time has come to move on from two-dimensional dishes to culture systems that better represent th...

Human stem cells delay start of Lou Gehrig's disease in rats

...periments offer "proof of principle" for stem cell grafts and that a more complete transplant of cells - already being planned -- along the full length of the spine to affect upper body nerves and muscles as well might lead to longer survival in the same rats. "We only injected cells in the lower spine...

Replacing insulin is top-ranked breakthrough foreseen for health in developing world

...promise of more affordable treatments than corneal grafts and of offsetting shortages of donor material. The study, the first of its kind: Identifies and prioritizes applications of regenerative medicine that could effectively improve health in developing countries; Assesses the feasibility of building...

Stem cells found in adult hair follicles may provide alternative to embryonic stem cells

...edical engineering at Marquette University, if the grafts lead to an improvement of spinal reflexes in the injured spinal cord of mice. Dr. Sieber-Blum points out that the cells may also be useful to treat Parkinson's disease, multiple sclerosis, Hirschsprung's disease, stroke, peripheral neuropathies and...

Are scientists making progress in being able to regenerate bone tissue?

... Until recently, say the authors, the use of bone grafts from a different part of the patient’s own body ha...tive is to use bone given by a donor—but such bone grafts from donors are less successful and there is a risk of transmitting viruses from the donor to the re...

New protein inhibitor impedes growth of cancerous cells

...ancers, and it inhibited the growth of human tumor grafts in mice, resulting in the death of tumor cells and regression of large tumors. The authors report that BI 2536 has now been brought into use in clinical studies of patients with locally advanced or metastatic cancers in order to address the therapeut...

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