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Tag: "globin" at biology news

Affymetrix Launches New Globin-Reduction Kits and Protocol Developed with PreAnalytiX

...expression by reducing the overwhelming amounts of globin messenger RNA (mRNA) present in whole blood. Large amounts of globin mRNA can significantly interfere with gene expression assay results. High globin mRNA levels contrib...

Sickle cell disease corrected in human models using stem cell-based gene therapy

...have the disease. The vector carried a therapeutic globin gene harboring an embedded small interfering RNA p...gineering strategy combining RNA interference with globin gene transfer by creating a therapeutic transgene, consisting of the gamma-globin gene and small int...

Researchers show key protein necessary for normal development of red blood cells

... called KLF2 regulates the production of embryonic globin genes and the maturation and stability of embryoni...ble for controlling and "turning on" the embryonic globin gene. "Understanding how genes are turned on and off, and the switch from the embryonic globin gene...

'Insulator' helps silence genes in dormant herpes virus

... chicken, namely the yeast mating loci and chicken globin locus. To see if insulators play a role in silencing viral genes during the latent phase, Zhou and his group studied cells infected with HSV-1. The studies showed that during a latent period, the virus binds to a host protein called CTCF, a protei...

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