Tag: "glioma" at biology news

UCSF brain tumor vaccine trial shows promising results

...“Our goal is to change the management of recurrent glioma from a life threatening disease, in which survival rates are typically 25 to 26 weeks, into a chronic disease with extended survival and improved quality of life for patients,?Parsa said. “Although our survival data are encouraging, a larger phase 2 ...

Newly identified biomarker detects and regulates spread of brain tumors

...f patients with malignant astrocytoma and mediates glioma cell migration," is published in the November issue of Clinical Cancer Research. The biomarker, a protein known as "soluble attractin," is normally absent in the central nervous system (CNS) and is undetectable in cerebral spinal fluid (CSF), unle...

Vaccine for brain tumors shows promising results

...e cells. The most common site of involvement of a glioma is the brain. Malignant glioma is currently a fatal disease. The trial results are being presented at the Immunotherapy Task Fo...

Cancer stem cells linked to radiation resistance

...e. The researchers first measured the number of glioma stem cells present in the original tissue and then... observed a roughly fourfold jump in the number of glioma stem cells present in the tumor tissue following radiation treatment. Because ionizing radiation ...

Targeted virus compels cancer cells to eat themselves

...te. The modified adenovirus homed in on malignant glioma cells in mice and induced enough self-cannibalizat...iptase promoter regulated adenovirus) infected the glioma cells and induced autophagy by inactivating a molecular pathway -- the mammalian target of rapamyci...

Mayo Clinic Cancer Center: Harnessing the measles virus to attack cancer

...hat measles virus strains can significantly shrink glioma tumors and prolong animal survival. It is very rewarding to see this work maturing to the point of now being able to offer this novel and promising treatment approach to patients with recurrent glioblastoma multiforme." She also reports that toxico...

Unique dual target specificity of kinase inhibitor key for success against cancer

...proliferation of a broad range of lethal malignant glioma cells in vitro and in vivo. The findings, publishe...e critical for growth and progression of malignant glioma cells. UCSF colleagues Zachary Knight and Kevan Shokat synthesized and characterized a series of nov...

Possible birthplace of malignant brain tumors identified

...rom diagnosis to death for patients with malignant glioma is currently only 14 months." ...

Radioactive scorpion venom for fighting cancer

...ters the bloodstream, the compound attaches to the glioma cells, then the I-131 releases radiation that kills the cell. This compound has enabled an experimental treatment for high-grade gliomas, found in 17,000 people in the US every year and usually causing death in the first year of diagnosis. Patien...

Marrow-derived stem cells deliver new cytokine to kill brain tumor cells, offer protection

...system cells ?have the ability to target and track glioma cells in the brain, even as they migrate. The rese...gulate immune responses ?to track down and destroy glioma cells. In 2002, the scientists reported that they had produced central nervous system cells from st...

Growth factor-promoting angiogenesis expressed in tumor cells and normal neurons

...types. Research has shown that SCF is expressed in glioma cells and as a result of various types of brain in...reased angiogenesis and improved survival in mouse glioma models, whereas overexpression of SCF is associated with a worse prognosis and shorter survival in p...

Mobile phone use not linked to increased risk of glioma brain tumours

... of tumour. There was no relationship for risk of glioma and time since first use of a mobile phone, lifeti...al effect. This finding may be due to people with glioma brain tumours linking mobile phone use to the side of the tumour and therefore over reporting the us...

Infections could contribute to adult brain tumours

...een 1983 and 2001. They found clusters of cases of glioma tumours, which make up about half of all brain tumours, at different time intervals in different geographical locations. This 'space-time clustering' of cases is a pattern typical of diseases caused by infections, adding weight to the theory tha...

Mouse brain tumors mimic those in human genetic disorder

... to determine whether a childwith an optic pathway glioma should undergo treatment for the tumor,including t...tory of neurofibromatosis 1-associated optic nerve glioma formationin mice. Annals of Neurology, January 2005....

Columbia research lifts major hurdle to gene therapy for cancer

...cancer cells from melanomaand ovarian, breast, and glioma (brain) tumors.Dr. Fisher's team is now altering the virus and developing additionalviruses based on the PEG switch for use in clinical trials withpatients. Other investigators associated with the PNAS study includeDrs. Zao-zhong Su (research scienti...

1