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Tag: "glial" at biology news

Controversial drug shown to act on brain protein to cut alcohol use

...byincreasing the level of a brain protein known as glial cellline-derived neurotrophic factor, or GDNF. In a separate study, theydemonstrated that GDNF by itself decreases alcohol consumption.The research is being published in the January 19 issue of The Journalof Neuroscience."By identifying the brain pro...

Gene Therapy For Parkinson's Disease Moves Forward In Animals

...esearch team. The protein, called GDNF, short for glial cell line-derived neurotrophic factor, is believed to preserve brain cells and could provide protection against Parkinson's disease. But its use has been debated since trials in humans ended last year without showing clinical improvements. Amgen, the...

Zebrafish may hold key to understanding human nerve cell development

...sing zebrafish as a model, we've demonstrated that glial cells play apreviously unidentified role in regula...chool of Medicine. Scientistslong have known that glial cells, or simply glia, are essential forhealthy nerve cells. However, in the last 10 years scientist...

Harmful Bacterium Commonly Found in Poultry May Survive Refrigeration and Frozen Storage Combined

...sing zebrafish as a model, we've demonstrated that glial cells play apreviously unidentified role in regula...chool of Medicine. Scientistslong have known that glial cells, or simply glia, are essential forhealthy nerve cells. However, in the last 10 years scientist...

GenMAPP 2.0 released

...sing zebrafish as a model, we've demonstrated that glial cells play apreviously unidentified role in regula...chool of Medicine. Scientistslong have known that glial cells, or simply glia, are essential forhealthy nerve cells. However, in the last 10 years scientist...

Gene therapy for Parkinson's disease moves forward in animals

...esearch team. The protein, called GDNF, short for glial cell line-derived neurotrophic factor, is believed to preserve brain cells and could provide protection against Parkinson's disease. But its use has been debated since trials in humans ended last year without showing clinical improvements. Amgen, th...

Rats infected as newborns grew up vulnerable to memory problems during an immune challenge

...ly alterationS may be to the basic architecture of glial cells called astrocytes within the hippocampus, which in turn help the central nervous system respond to injury or infection. Because astrocytes also help to determine the number and connectivity of nervous system synapses early in life, especially t...

Silence the gene, save the cell: RNA interference as promising therapy for ALS

...es that mutant SOD1 gene expression in neighboring glial cells is also implicated in motor neuron death. L...down in the affected motor neurons and neighboring glial cells, and both the onset and the rate of progression of the disease in the treated mice were substa...

Revolutionary nanotechnology illuminates brain cells at work

...e brain over the coming years, such as the role of glial cells in the process of glutamate removal from the synaptic cleft. It's fascinating to see a tool that we are using in plant biology open new areas in neuroscience." ...

Researchers find molecule that inhibits regrowth of spinal nerve cells

... does myelin encourage the growth of scars ?called glial scars ?which physically block nerve cells from reg...ients. "We have to figure out how to dissolve the glial scars or impede their formation," he said. "We also need to get mature neurons to be better at growi...

Discarded placentas deliver researchers promising cells similar to embryonic stem cells

...ferentiate to become liver cells, heart cells, the glial and neuronal cells that make up the nervous system, and pancreatic cells with genetic markers for insulin and glycogen production. "In this first paper we sought to determine if amniotic epithelial cells have the potential to differentiate into many...

Penn study finds direct role for glial cells in brain cross-talk

...ool of Medicine have demonstrated that star-shaped glial cells in the brain called astrocytes are directly ...transmission of a nerve impulse. Historically, the glial cell or astrocyte was considered to be a support cell and to play no active role in regulating nerve...

Engineered Stem Cells Show Promise For Sneaking Drugs Into The Brain

... a protective barrier erected by blood vessels and glial cells -- the brain's structural building blocks --...ered the cells to produce a growth factor known as glial cell line-derived neurotrophic factor (GDNF). In some small but promising clinical trials, GDNF show...

OHSU discovery sheds light into how stem cells become brain cells

...ges, these same stem cells suddenly start becoming glial cells, which perform a number of functions that in...smaller brains containing neurons but virtually no glial cells. When they isolated neural stem cells, placed them into cell culture and then removed Brg1, th...

Powerful new tool for studying brain development

...onstrated that specific brain cells, called radial glial cells, likely gave rise to ependymomas. "Our demonstration that identical-looking ependymomas that arise in different regions of the central nervous system are distinct diseases because they arise from different stem cells is an important insight,"...

New compound stops brain cell degeneration in Alzheimer's disease

.... The report demonstrates that targeting excessive glial activation can suppress brain inflammation and neuron dysfunction in the hippocampus and protect against cognitive decline in an animal model. Neuron dysfunction can lead to further glia activation and contribute to further exacerbation of the disea...

Neuronal cell cultures kept on the straight and narrow

...lular support services. There are usually far more glial cells than neuronal cells, which makes it hard to ...ronal cells and measure their activity against the glial background. In a paper in the American Chemical Society's journal Langmuir*, NIST researchers detai...

Stem cells found in adult skin can be transplanted and function in mouse models of disease

...found that SKPs can efficiently generate a type of glial cell, called Schwann cells, that can myelinate demyelinated axons (part of a neuron), and that have been shown to provide a good growth environment for injured central nervous system axons. These types of axons normally do not regenerate. "Schwann...

Human stem cells delay start of Lou Gehrig's disease in rats

...of one particular factor, known as GNDF (short for glial cell derived neurotrophic factor) in spinal cord fluid. The transformation of the transplanted cells also may allow them to deliver these growth factors to other cells in the spinal cord through physical connections. Cautioning that clinical appli...

Vaccine for brain tumors shows promising results

...ma is a type of primary tumor that arises from the glial cells, the connective tissue cells that surround and support nerve cells. The most common site of involvement of a glioma is the brain. Malignant glioma is currently a fatal disease. The trial results are being presented at the Immunotherapy Ta...

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