A link is found between morphine addiction and the tendency to explore
...associated with the effects of this drug, and this gives us an indication of the rat's addiction to the drug. ...New RNAi tools enable systematic studies of gene function
...onse will be accelerated using these tools." RNAi gives scientists the ability to turn off an individual gene. Its workhorses are small RNA molecules, each of which is tailored to match a fragment of a gene's unique DNA. This RNA can then bind to its gene target, rendering it inactive. In order to get the...The closest look ever at the cell's machines
...ited what we know about how cells work. This study gives us a nearly complete parts list of all the machines, and it goes beyond that to tell us how they populate the cell and partition tasks among themselves." The study combined a method of extracting complete protein complexes from cells (tandem affinit...A surprising pair of proteins help make healthy eggs
... Biology and Biochemistry at Brown. "This research gives us important new information about fertility. It's a basic science finding, but it may provide answers for some of these women and, possibly, lead to better in-vitro fertilization therapies." In 2001, Freiman and colleagues at Berkeley published a p...'Executive' monkeys influenced by other executives, not subordinates
...st social perception. Such a discovery in monkeys gives the researchers an invaluable animal model that enables them to tease apart the reflexive-versus-social mechanisms that govern behavior, they said. In particular, they can begin to understand the physiology and neural machinery of status, they said....U of MN researchers identify ataxia gene
...t that will lead to improved patient diagnoses and gives us new insight into the causes of ataxia and other neurodegenerative diseases, an important step towards developing an effective treatment," said Laura Ranum, Ph.D., senior investigator of the study and professor of Genetics, Cell Biology and Develop...New DNA 'fingerprinting' technique separates hemp from marijuana
...r number of markers, compared to other techniques, gives us the power to separate the cultivars." The Cannabis plant has been cultivated for millennia and is important in the global economy as both a licit and an illicit crop, said Weiblen. Hemp is a source of durable fiber that provides an alternative to...Mayo Clinic collaboration discovers protein amplifies DNA injury signals
...lth. DNA must repair itself so the instructions it gives to operate bodily functions are correct. In earlier work, the Mayo Clinic researchers determined that MDC1 is important to the repair process -- but they didn't know its role. DNA is easily and often damaged by environmental and chemical sources suc...'Nano-keys' bind cell receptors and trigger allergic reactions
...ith ambiguous results. However, nanotechnology now gives researchers new tools to understand the role of cell membranes in activating responses within cells. Barbara Baird, Cornell professor of chemistry and chemical biology, reported this research today (Feb.16) at the annual meeting of the American Asso...New influenza vaccine takes weeks to mass produce
...of these antigens and the successful purifications gives us a great advantage in fighting against a potential influenza pandemic, if it derived from any of these strains," says Wang. "Starting from a stocked recombinant baculovirus bank, a closely matched vaccine can be massively produced within 2 weeks."...Mouse to man: The story of chromosomes
... disorder [CMT1A]). The study of this chromosome gives a clearer picture of how genome changes through evolution, Lupski said. For example, breaks in synteny or the maintenance of the order of genes between species coincide with changes in the architecture of the chromosome itself. In some cases, DNA rep...On a fly's wing, scientists tally evolution's winners and losses
... disorder [CMT1A]). The study of this chromosome gives a clearer picture of how genome changes through evolution, Lupski said. For example, breaks in synteny or the maintenance of the order of genes between species coincide with changes in the architecture of the chromosome itself. In some cases, DNA rep...Wisconsin scientists find a way to make human collagen in the lab
...s to confront the effects of disease -- because it gives scientists a way to precisely manipulate the lengt... collagen. "We just don't have to take what nature gives us. We can make it longer and stronger." In medicine, synthetic human collagen could be used as "so...Findings advance use of adult stem cells for replacement bone
... matrix, or ECM, the boney, calcified deposit that gives bone its structural strength. A comparison was then run on these pre-generated ECM constructs and on non-treated titanium scaffolds. The pre-treated surfaces encouraged calcification at a much faster rate. The researchers also found up to 75 times m...Molecule does more than slice and dice RNA
...Dicer is a molecular ruler," Doudna explained. "It gives us a lot of insight into how the mechanism works." Dicer, which is ubiquitous in the cells of higher animals, including humans, is a widely studied molecule. It was first discovered in 2001 by Gregory J. Hannon, an HHMI investigator at Cold Spring H...Advanced genomics and proteomics improve the diagnosis and treatment of a deadly lung disease
...Dicer is a molecular ruler," Doudna explained. "It gives us a lot of insight into how the mechanism works." Dicer, which is ubiquitous in the cells of higher animals, including humans, is a widely studied molecule. It was first discovered in 2001 by Gregory J. Hannon, an HHMI investigator at Cold Spring H...It's in the genes: Study opens door to new treatment of the blues
...olanos said. "This study is significant because it gives us an animal model of the disorder and opens up new areas of study." In the experiment, the researchers subjected mice to daily bouts of social threats and subordination by aggressive rodents and continuous sensory contact with the aggressors for 10...The giant protein titin helps build muscles
...orative research by the Wilmanns and Gautel teams, gives a solution to how this might happen. Peijian Zou a...rom cell biophysics and structural biology, and it gives us a way to discover why some mutations in titin are linked to diseases," says Gautel. ...Measuring artery repair cells could become new heart disease test
...damage and repair, and now we may have a test that gives us insight into the repair portion of the equation." "If the results of this study are borne out, measuring EPCs could be a better test for defining an individual patient's risk for heart disease," Povsic said. "Theoretically, patients who are found......eir function and studied their evolution. The work gives the most complete understanding of capsule production in any bacterial species. The new vaccine will protect children from many of the most common serotypes but monitoring is needed to check whether other serotypes start to cause some disease. It is...