A new tool against brain disease
...d that you could actually change the PD-1 level by getting rid of the viral antigen with drugs," said Walker. An antigen is a protein on a virus or other infectious agent that triggers an immune reaction. Walker said one of the team's key findings emerged from their test tube studies showing that block...Fatty spheres loaded with siRNA shrink ovarian cancer tumors in preclinical trial
.... "This particle is so small, it has no problem getting through the tumor's vasculature and into the tumor," Lopez-Berestein says. The FAK-targeting liposome ranges between 65 and 125 nanometers in diameter. Blood vessels that serve tumors are more porous than normal blood vessels, with pores of 100 to ...What's nature worth? New computer models tell all
...els, and be able to identify a territory and start getting answers." For example, if a town council is trying decide the value of a wetland--compared to, say, building a shopping mall there--these models will help them put a dollar value on it. If a country wants to emulate Costa Rica's program of payment...Gene screen for breast cancer better than pathologist's 'eye'
...verlook any hidden breast ducts. Improvements in getting an accurate representation of fluid from all the breast ducts are underway by other investigators, and include using sound waves to locate all the ducts. ...Beekeepers work hard for the honey, despite changing tupelo forest
...ome beekeepers say that every year they seem to be getting less honey for their efforts. Stallins and Watson will explore the degree to which changing river hydrology, exotic pests, land development and other factors are affecting tupelo honey production, an important regional industry that contributes about...Study shows pine bark naturally decreases severe chronic venous insufficiency
...nol® also helps prevent existing spider veins from getting larger and more prominent. When edema is successfully treated, the increased pressure on veins gets normalized, preventing the veins from further increasing in size. "Pycnogenol® has demonstrated its efficacy and safety in several clinical trials a...Researcher gives hard thoughts on soft inheritance
..."In this particular instance that says what you're getting fed in the womb influences your phenotype ?physical and physiological attributes." Another study showed that early grooming and nurturing of rat pups by rat moms affects methylation of a glucocorticoid receptor gene in the hippocampus in th...Hopkins scientists show hallucinogen in mushrooms creates universal 'mystical' experience
...ffects and the likelihood that the expectations of getting the test drug or the placebo would influence subjects' perceptions. To lessen the former, each subject met several times, before drug sessions began, with a reassuring "monitor," a medical professional experienced in observing drug study participa...Experimental vaccine protects lab animals against several strains of H5N1
...te ferrets. The vaccine protected the ferrets from getting sick when exposed not only to the flu strain from which the vaccine was made, but also two other strains, including a deadly strain labeled A/Vietnam/1203/04. Cross-strain protection is exactly what one would need, as it would protect against newly ...Compound in dairy products targets diabetes
...y mimic the natural activators of the receptors by getting into the cell and interacting with the PPARs to regulate glucose and fat metabolism," says Vanden Heuvel. Early human trials indicate that when administered for longer than 8 weeks, CLA improves the body's misregulation of insulin and lowers the ...University of Minnesota researchers take new look at cellular suicide
...nly culling damaged cells but shaping an embryo by getting rid of webbing tissue between fingers and toes. By contributing to the understanding of how apoptosis works, the researchers, led by Zigang Dong of the university's Hormel Institute in Austin, Minn., hope someday to see the process used to kill cance...Major initiative proposed to address amphibian crisis
...lia in recent years. And the problem appears to be getting worse. Traditional programs and current laws and policies alone are insufficient to address global threats that cross boundaries of reserves and nations, the scientists said in their report. ...Just like us, social stress prompts hamsters to overeat, gain weight
...the stress we experience in everyday life, such as getting stuck in traffic or trying to complete a major project at work. It is distinct from traumatic stress, such as suffering the death of a loved one. Traumatic stress typically dulls the human appetite, said Bartness, the study's senior researcher and an...Three-in-one virus killer prevents common, often fatal infections
...novirus. "Not only were patients prevented from getting these infections after transplant, but those patients who had infections responded to the T-cell therapy and did not require any other treatment," said senior author Dr. Catherine Bollard, assistant professor of pediatrics, immunology, and medicine a...Jumping gene could provide non-viral alternative for gene therapy
...r more than 20 years because of their adeptness at getting inside cells and inserting themselves in DNA. But efficiency comes at a price. Gene therapy trials have been halted because of major complications, including deaths. As examples, one patient died because of his immune response to an adenovirus and th...MIT finds most complex protein knot ever seen
...t found in ubiquitin hydrolase may prevent it from getting sucked into the proteasome as it works, Mirny said. The researchers hypothesize that proteins with complex knots can't be pulled into the proteasome as easily, and the knots may make it harder for the protein to unfold, which is necessary for degrada...Researchers add to understanding of how brain cells communicate
...hich means it can flow through the channel without getting stuck in the middle. In addition to computer modeling, the researchers used the technique of patch clamp recording, which takes a tiny piece of cell membrane and measures the charge that flows through one open channel. They were able to use the rem...Bird flu vaccine additive may stretch supply
...ng to protect against is what protects people from getting the flu," said Robert Atmar, MD, lead author of th...l, the more likely people are to be protected from getting ill or from getting infected at all. "What we found was that when the adjuvant material was includ...Other patients bear the real cost of Herceptin
...rs. “We will be the ones to tell them they are not getting treatment that has been proved to be effective and which costs relatively little, because it is not the treatment of the moment.? These results are obviously not definitive, but illustrate the fundamental challenge facing the NHS ?the tension betwe...Contrary to common wisdom, scientist discovers some mammals can smell objects under water
...e bubble is inhaled." Just because the moles are getting whiffs of interesting odors underwater doesn't necessarily mean they smell them. So Catania devised some additional tests. One of the complicating factors was the star-nosed mole's unusual nose, which is ringed by a star-shaped set of fleshy appen...