For the first time: Longevity modulated without disrupting life-sustaining function
...e environment, but for some reason DAF-2 signaling gets turned off precociously, the worms reap the benefit of increased stress resistance and double their lifespan from an average of 20 to 40 days. Except the worms trade a trim life focused on reproduction for a long life with fewer progeny and a tendenc...Mayo Clinic researchers challenge sepsis theory
...a or in response to drugs -- is that this receptor gets released from its constraint. That's the first step that actually initiates sepsis." Research is underway to discover new therapies that could prevent, blunt or reverse the release of the constrained receptor. ...Poison dart frog mimics gain when birds learn to stay away
..., colorful frog living in the Amazonian rainforest gets protected from predators not by mimicking its most poisonous neighbor, but by looking like a frog who's poison packs less punch. The Texas biologists studied three species of poison dart frogs--one highly toxic species, one less toxic species and on...BioMed Central launches Biology Direct
...o in the conference room itself. Sometimes someone gets upset or offended but it is, definitely, an exception. And how priceless these discussions often are in providing us with new perspectives and fresh ideas for our research!" The initial response to the journal has been highly positive and the Editor...Scientists identify molecular structure of key viral protein
...logy, who co-led the study. "Knowing how the virus gets into the cell will allow us to better inhibit this key part of the viral life cycle." Tens of thousands of different proteins are at work in the human body, each folded into a very specific shape to do its job properly. Most proteins have just one s...Pennsylvania researchers find liver transplants provide metabolic cure for rare genetic disease
...om proteins to accumulate in the body. The disease gets its names from the sweet smell of the urine. The accumulation of amino acids in the blood can cause metabolic crisis at any age, which can lead to brain swelling, stroke and even sudden death. Over a patient's lifetime, chronic instability of blood ...Inside rocks, implications for finding life on Mars
... of the laser light is scattered, but a small part gets absorbed by the fossil. Schopf is the first scientist to use this technique to analyze ancient microscopic fossils. He discovered that the composition of the fossils changed; nitrogen, oxygen and sulfur were removed, leaving carbon and hydrogen. Co...Weighting cancer drugs to make them hit tumors harder
...ubstances as a means of ensuring that chemotherapy gets into cancer cells." Chilkoti said their findings also are important because they can be used to optimize drug delivery of all macromolecular therapeutic agents, including cytokines, antibodies and anti-angiogenic drugs." ...Tiny shock absorbers help bacteria stick around inside the body
...h bond" that acts like a finger trap, and actually gets stronger as drag force is exerted on a bacterium. Rather than being swept away by fluids moving through the human body, the bacterium grips even more tightly, helping it stick around and form an infection, like those seen in the urinary tract, for in...Chewing up a key regulator of fat synthesis keeps mice lean despite a high-fat diet
...odification of ACC, known as ubiquitination, which gets rid of the enzyme altogether. "In this parallel pathway, TRB3 serves as a go-between for an enzyme that marks ACC for degradation," says Jose Heredia, a graduate student in Montminy's lab. TRB3 levels in adipose tissue usually rise only during fast...Research identifies protein in mice that regulates bone formation
...l die within a year. As the baby boomer generation gets older, it is predicted that the number of hip fractures may triple by 2020 unless better prevention and treatment for the disease is improved. The researchers, led by Dallas Jones, a research associate in the Department of Immunology and Infectious...... ecosystem processes. "The Bureau of Reclamation gets restoration out of this project, and we get this incredible experiment," said Whitham. All of the experiments, so far, have exceeded the researchers' expectations. "Initially we thought that the [genetic influences] would be more localized--that the...NASA technology helping injured US troops
...herapists helping them," explained Messier. "So it gets the patient up sooner in the rehabilitation process without a fear of falling and without injuries to the patient or staff." According to Messier, one active military patient at Walter Reed who was wheelchair-bound for two years due to a spinal co...MIT 'seeing machine' offers hope to blind
...y containing some of Goldring's art. When a person gets close enough to a piece, the work is explained in Goldring's voice. ...Rice scientists unveil 'nanoegg'
...th of the plasmon, the amplitude of their sloshing gets bigger and bigger, much like the waves in a bathtub when a child rhythmically sloshes bathwater until it spills out of the tub." In order for plasmons to be excited by light, the electrons on a particle's surface must behave in such a way as to cre...The vicious cycle of rainforest destruction
...s in the tropics are rainforest and savanna. As it gets warmer and drier the rainforest gets invaded by savanna, which has fewer trees and holds less carbon in the soil. Savanna also doesn't re...Life and death in the hippocampus: what young neurons need to survive
...tor had been eliminated. Listening to Gage, one gets the impression that the hippocampus is a dangerous place for a fledgling neuron trying to elbow its way into pre-existing networks. "It's rough in there!" he concedes. "The NMDA receptor-mediated event is a competition between mature cells vying for ...New strategy rapidly identifies cancer targets
...and division. Sometimes, though, a tyrosine kinase gets stuck in an "on" position, driving out-of-control cell division and, ultimately, cancer. This potentially devastating kinase activation carries a calling card in the form of a molecule called a phosphate. "The phosphates signal activated tyrosine ...Finding paves way for better treatment of autoimmune disease
...helps destroy non-regulatory T cells when the body gets too many, say after fighting a big infection, and that it may not work well enough in people with autoimmune disease. ......emerged from this logical approach is that Pol IVa gets things started, churning out RNA that then goes to the nucleolus where it is acted on by RDR2, which turns the single-stranded RNA into double-stranded RNA. The Dicer-like 3 protein, DCL3 then chops the RNA into small interfering RNAs (siRNAs). Alo...