Shutting down the HIV assembly line
... that point, none have tackled how the Gag protein gets there in the first place. The current work fills t...f this paper comes from really identifying how Gag gets to the multivesicular body and in demonstrating that if you block that trafficking step specifically...Advancements In Genomics Foster Deep Sea Discoveries
...sure. “There’s a protein within the membrane that gets squeezed when the cells experience higher pressure, and that triggers a signal transduction event that activates the expression of genes that help the cells to adapt to the increased pressure,?said Bartlett. The scientists found other tantalizing dis...Road salt affects mitigation wetlands
... a huge safety issue in a part of the country that gets 10 to 12 feet of snow every winter." Silver's research does show a large decrease in non-biting midges in the designated runoff wetland. The effect on other species is not yet known. There was no decrease in midges from the slightly salty wetland. I...NSAID drug protects against intestinal tumors in mice, despite poor diet and gene losses
...oncept further, including exactly how the p21 gene gets activated." ...Secret of smallpox's success may lead to bioterror cure
... mutant virus ?only 100 virus particles ?the mouse gets sick but eventually recovers. The more mutant virus the mice are given, the less sick they become. "If you give them a million particles, they don't even get sick -- the animals stay healthy," notes Jacobs. "The body reacts and it fights off both t...Man-made wetland's effectiveness similar to natural marsh
...based compound found in fertilizer. "As a wetland gets older, it gets better at handling and storing nitrogen," Mitsch said. "The idea is not to overload wetlands in the ...Tendency to hair loss inherited from the mother
...mes higher, the hair at the back of the man's head gets thinner and thinner. Every second man suffers from greater or lesser hair loss. There are hardly any successful counter-measures ?despite an enormous range of obscure lotions and tinctures. It has long been suspected that hereditary factors are impo...Gene keeps neural cells on correct developmental path
...nding with shutting down the REST gene. "The cell gets rid of all the excess protein, kicks it off the DNA, then stomps on its head so it can't make RNA," Mandel said. "We can't detect REST in the terminally differentiated neuron." But some molecular partners of REST remain, perhaps fine-tuning gene expr...Chimp genome reveals a retroviral invasion
...called endogenous when it invades the germline and gets passed on to offspring. Because endogenous retroviruses can alter gene function and genome structure, they can influence the evolution of their host species. Over 8% of our genome is made of these infectious remnants -- infections that scientists bel...Some Brain Cells Change Channels
...the cells' AMPA receptors, and so too much calcium gets inside. If these threatened nerve cells can swap their calcium-allowing channels for the kind that keeps calcium out, it might be possible to harness that switch to prevent the cells from dying. "But that's a big 'if' at this point," says Huganir. ...Shark attack worries? Driving to the beach is more deadly
...rplane trips are safe, but when a crash occurs, it gets big headlines. If you use some good common sense in the water, you should be fine." ...New HIV drug candidate developed in Sweden
...rplane trips are safe, but when a crash occurs, it gets big headlines. If you use some good common sense in the water, you should be fine." ......rplane trips are safe, but when a crash occurs, it gets big headlines. If you use some good common sense in the water, you should be fine." ...High fidelity keeps human DNA assembly line humming
...several ways. If it doesn't match the criteria, it gets booted out." In addition to better understanding how errors are prevented, Burton's research team also learned ways errors are corrected during rapid RNA synthesis. To learn about error correction, Burton's team stalled the DNA conveyer belt. They d...Random gene expression may drive HIV into hiding
...ring. But the new results show that "any cell that gets infected can go down one of two paths," Weinberger said. Weinberger now is a postdoctoral fellow at Princeton University. Inspired by work that Arkin had done in the 1990s, showing that random fluctuations in viral gene expression can influence lat...Two studies document rise of superbugs in the environment
As science gets wiser, so do the bugs. The rates of drug-resistant bacteria infecting patients in the community and in the hospital have been increasing steadily in recent years, according to two new studies in the June 15 issue of Clinical Infectious Diseases, now ...Proteomics brings researchers closer to understanding microbes that produce acid mine drainage
...production of acid mine drainage. "This is how it gets its food, this is its mechanism for harvesting energy from the environment," said Banfield. "It's probably the first step in the electron transport chain associated with the metabolism of the organism." Interestingly, many of the proteins produced b...Speak up: Louder neurons form more connections
... grow follows an age-old axiom: The squeaky neuron gets the grease. “Louder neurons drown out their quieter neighbors,?Smith said. Working out this seemingly simple rule took some technical finesse. Hua created zebrafish with a few brain cells that made a protein that prevented them from firing their nor...Confirmation of human protein interaction data by human expression data
... grow follows an age-old axiom: The squeaky neuron gets the grease. “Louder neurons drown out their quieter neighbors,?Smith said. Working out this seemingly simple rule took some technical finesse. Hua created zebrafish with a few brain cells that made a protein that prevented them from firing their nor...Purdue scientists may have found key to halting spinal cord damage
...," Shi said. "After the initial shock, it actually gets worse. Science has long been aware that some chemicals the damaged cells release are part of the problem, but no one has ever been sure which chemicals are responsible." When a spine is damaged, the change in its ability to function follows a well-d...