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Tag: "genomic" at biology news

Identified main genetic variants involved in response to HIV

...tions affecting only one nucleotide or base of the genomic sequence. Despite humans sharing 99.9% of the genome sequence, there are still 3 million genetic variations –which make us different from one another– 90% of which are due to SNPs. Hence, a good knowledge of these variations is highly valuable for th...

New findings challenge established views on human genome

...and correlation of these signatures with different genomic functions. Deeper understanding of how DNA replication is coordinated by modifications in histones. “Teamwork was essential to the success of this effort. No single experimental approach can be used to identify all functional elements in th...

Exploring the dark matter of the genome

...'s end-caps; they help prevent the accumulation of genomic damage. Both heterochromatin and euchromatin are sequenced using a method called whole-genome shotgun sequencing. Celniker says, "We grind up whole flies and produce libraries of DNA fragments of two sizes, some that are 2 kilobases long" -- a ki...

Human genetic 'deserts' are teeming with significant life

...rofessor Reymond. “They increase the size of the genomic regions that might harbour disease-causing mutations, and they could impair cloning strategies that try to find genes implicated in these pathologies.” They also suggest that extra caution should be used when associating a genetic phenotype with a...

Genome of Clostridium botulinum reveals the background to world's deadliest toxin

...ility of this tool should revolutionise functional genomic studies in clostridia." This remarkable, stable genome demonstrates the wide range of strategies used by bacteria to enhance their chances of survival. For the Clostridia, these range from the approach used by Cdiff — long-term interaction with ho...

The sound of proteins

...on-impaired scientists and boost the popularity of genomic biology. New research published today in the open access journal Genome Biology describes how researchers have found a way to present human proteins as musical notes. Rie Takahashi and Jeffrey H. Miller from the University of California, Los Angeles...

Baumann Lab defines proteins that distinguish chromosome ends from DNA double-strand breaks

...hat loss of chromosome end protection can initiate genomic instability through bridge-breakage-fusion cycles. It is, therefore, very important to understand the mechanism of chromosome end protection and how and why it fails during tumorigenesis." ...

Beyond the DNA: Chemical signatures reveal genetic switches in the genome

...ional algorithms that identified hundreds of novel genomic regions with regulatory potential." Moreover, says Heintzman, this 'histone code' was able to accurately distinguish between promoters, from which gene transcription is directly initiated, and enhancer regions - some of which are very distant from th...

Despite their heft, many dinosaurs had surprisingly tiny genomes

...rough evolutionary time," Edwards says, "providing genomic information that's often unavailable for long-extinct ancestors." ...

Mine runoff continues to provide clues to microbial diversification

... this is the first observation of exchange of huge genomic blocks in a natural microbial community. “Conse...extensive reconstruction of genomes from community genomic data at UC Berkeley was key to this work, said Jill Banfield, who led the project. Banfield, a profe...

Researchers identify gene involved in dog size

...or influence on stature in dogs. Based on their genomic analysis, the researchers also concluded that the small size trait emerged relatively early in the history of domestic dogs. They hypothesize that small size may have facilitated the rapid diversification among domestic dog breeds by making it easier...

Analysis of rhesus monkey genome uncovers genetic differences with humans, chimps

...omedically important traits in rhesus. The rhesus genomic DNA samples used for these studies were contributed by the California NPRC, Oregon NPRC, Southwest NPRC and Yerkes NPRC. This advance in macaque genetics will enhance the use of macaques for the study of genetic diseases of man. ...

Darwin's famous finches and Venter's marine microbes

...oughly 7.7 million sequenced snippets of sea-borne genomic DNA to impose order on the flood of data and to cl...n as environmental genomics) that seeks to examine genomic snapshots taken directly from the environment. "Metagenomics allows us to sample the 99 percent ...

DNA ends: Common tool, different job

...e evolved, each making individual contributions to genomic stability," says the study's lead author Vicki Lundblad, Ph.D., a professor in the Molecular Cell Biology Laboratory at the Salk Institute. With each round of cell division, telomeres ?long stretches of repetitive DNA ?erode a little bit further. ...

Genes and biomarkers that allow doctors to choose the right therapy for the right patient

...es represents a single variant among the different genomic abnormalities found among breast cancers. They me...Tykerb. "Our goal is to apply advanced cellular genomic strategies to assist clinical drug development by finding gene states that predict a patient’s respo...

Scientists to track impact of Asian dust and pollution on clouds, weather, climate change

...eurobiology what microarray technology has been to genomic science -- a fundamental breakthrough," Ehlers said. Microarray technology enables scientists to screen thousands of genes at once to look for clusters of genes that may be involved in disease. Although there are many approaches to studying how di...

Common algae helps illustrate mammalian brain electrical circuitry

...eurobiology what microarray technology has been to genomic science -- a fundamental breakthrough," Ehlers said. Microarray technology enables scientists to screen thousands of genes at once to look for clusters of genes that may be involved in disease. Although there are many approaches to studying how di...

Gene expression test reveals ER and HER-2 status of breast tumors

...online. Researchers developed and validated a new genomic microarray test that identifies whether a tumor's ...osis and treatment planning based on an integrated genomic test of an individual tumor," said senior author W. Fraser Symmans, M.D., associate professor in the...

Penn researchers replace organ in adult mice using 'single-parent' stem cells

...because mammalian embryos rely on a process called genomic imprinting, where cells will read certain genes fr...rents would interfere with the natural outcomes of genomic imprinting," McLaughlin said. "It turns out that genomic imprinting may be more a concern for devel...

Triplex assay used to assay duplex genomic DNA

...ssay of pathogens in samples also containing human genomic duplex DNA and to the assay of SNPs present in human genomic samples. The assays are carried out homogeneously and in solution at room temperature. Reactions can...

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