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Tag: "genetically" at biology news

St. Jude study solves mystery of mammalian ears

...nd itself. Therefore, the team developed a line of genetically modified mice that carried only mutant prestin in their outer hair cells. The researchers then tested the animals’ responses to sound. Results of the studies showed no alteration in hearing, which suggested that it did not matter whether the outer ...

Cellular message movement captured on video

...inner membranous lining of a cow aorta. They added genetically engineered proteins tagged with red and green fluorescence markers to the bovine aortic endothelial cells, grew them in tissue culture, and filmed them while they passed fluid across the cells’ surface in a simulation of flowing blood. With that phys...

Brain inflammation may be friend, not foe, for Alzheimer's patients

...ate professor of Neurobiology and Anatomy. Shaftel genetically engineered a one-of-a-kind mouse that gives him pinpoint control over brain levels of a human molecule known as interleukin-1beta, a well-recognized molecular kingpin in the realm of inflammation. IL-1 beta, a signaling molecule that promotes brai...

Gene therapy delivery of nerve growth factors reverses erectile dysfunction in animal model

...GDNF) or the GDNF family ligand (neurturin) into a genetically engineered herpes simplex virus (HSV). They then injected either of the recombinant viruses into the damaged cavernous nerve of rats. GDNF is an important nerve growth promoter and has been shown in other studies to contribute to survival and regener...

Discovery in orange cauliflower may lead to more nutritious crops

...The research provides a possible new technique for genetically modifying staple crops to increase their ability to store beta-carotene and increase nutritional content in staple crops." Other researchers have created "golden rice" by inserting several genes that increases the synthesis of beta-carotene. But th...

New bacterium discovered -- related to cause of trench fever

... other institutions, found that the new microbe is genetically similar to one spread by body lice in the trenches during World War I. That bacterium, called Bartonella quintana, caused a disease known as trench fever, and debilitated tens of thousands of soldiers with severe leg and back pain and recurrent fever...

In mice, drug protects against diabetes and atherosclerosis

...ry mice that had been fed unhealthy diets and were genetically predisposed to these common killers, according to ... culture and in live mice. In one experiment, mice genetically engineered to be highly susceptible to atherosclerosis were fed high-fat diets and assigned to recei...

Brain holds clues to bipolar disorder

...o can help predict which patients of those who are genetically predisposed to bipolar disorder will develop symptoms of the disease....

New study finds genetically engineered crops could play a role in sustainable agriculture

...d environmental scientists studying the effects of genetically engineered crops. Biotechnology and genetic engin... few analyses exist that reveal the actual effects genetically modified plants have on other non-modified species. In an analysis of 42 field experiments, scienti...

Genetic factors are linked to fever following smallpox vaccination

...eople who develop fever after vaccination may have genetically determined differences in their immune responses compared to those who do not. They studied 346 individuals who had participated in previous smallpox vaccination trials, 94 of whom developed fevers after vaccination. The authors analyzed 19 gene clu...

Herpes virus hijacks DNA repair process

...the DNA damage response. When the research team genetically disabled orf36 in the murine herpes virus and infected mouse cells with it, the virus no longer activated the DNA damage response. The virus's ability to replicate also dramatically decreased. Kinases are versatile proteins that sometimes play mul...

Mutating the entire genome

....” Capecchi says it now costs about $10,000 to genetically engineer a mouse with a particular gene or other DNA sequence knocked out. So using existing technology to knock out the estimated 20,000 mouse genes would cost $200 million, and knocking out the roughly 300,000 non-gene DNA sequences in mice would c...

Researchers demonstrate way to control tree height

...time, money and testing that current regulation of genetically modified organisms would require, at least in the ...nt types of genetic insertions to create about 600 genetically modified trees. All caused decreased signaling by gibberellic acids. They were grown in the field wi...

Weizmann Institute scientists develop a general 'control switch' for protein activity

...stage of the method consists of preparing a set of genetically engineered proteins (called a “library” in scienti...e damaged proteins that cause severe diseases with genetically engineered proteins, and to control these proteins’ activity levels in a precise manner by giving ap...

CU study reveals why starling females cheat

...side their group if they sense their mates are too genetically similar to themselves. Mating with strangers increases their brood's genetic diversity, even though it does not reap additional help. As yet, it is unknown how females detect the genetic similarities between themselves and their mates, though other s...

Modified mushrooms may yield human drugs

... research scientist, have developed a technique to genetically modify Agaricus bisporus -- the button variety of ... normal cells, separating out those that have been genetically altered for resistance. The test demonstrates that if a second gene, insulin for example, were to...

Experimental gene therapy 'abolishes' arthritis pain and lessens joint damage

...ile the study was done in mice, they are the first genetically engineered to develop osteoarthritis like humans, with the same genetic predisposition that makes some more likely to develop the disease, the authors said. If all goes well with a follow-up study currently underway, researchers will apply to the U.S...

'Smart' mice teach scientists about learning process, brain disorders

Mice genetically engineered to lack a single enzyme in their brains are more adept at learning than their normal cousins, and are quicker to figure out that their environment has changed, a team led by researchers at UT Southwestern Medical Center has found. The re...

Skimmed milk -- Straight from the cow

...ay also overcome the problem of waste. ‘If you can genetically produce milk without fat then that may turn out to be a very good solution to what might later be a big disposal issue,’ says Komorowski. Producing skimmed and semi-skimmed milk means there is a lot of fat left over. Komorowski noted, however, th...

Detecting cold, feeling pain: Study reveals why menthol feels fresh

...sponsive to cooling agents, including menthol. The genetically engineered mice did not discriminate between warm and cold surfaces until the temperature dropped to extremes. "It's been known for years that menthol and related cooling agents evoke the psychophysical sensation of cold – somehow by interacting w...

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