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Tag: "genetic" at biology news

Cellular Defects in Premature Aging Disease are Reversible

...years ago, NIH-led researchers discovered that the genetic basis for HGPS is a single mutation in the gene encoding lamin A. Lamin A is a critical structural protein that acts as the scaffolding which holds a cell's nucleus together. Lamin A is defective in HGPS cells because the mutation creates an aberrant...

Disease progression model of pancreatic cancer developed by Penn researchers

...rmation of mutated chromosomes–leads to widespread genetic changes throughout the affected cells. Genomic ins... Hingorani suggests, "there may actually be unique genetic routes to pancreatic cancer, such that not all pancreatic cancers are equivalent." The development ...

The biggest family tree ever

... in the world's most ambitious project tracing the genetic and migratory history of the human race. Members ...at The University of Arizona in Tucson will do the genetic analysis. The public DNA sampling is part of a larger undertaking to unravel the origins and migrato...

Agilent Technologies new genome analysis technology set to accelerate Australia fight against mesothelioma

...allow researchers to rapidly and reliably identify genetic changes in tumorous cells. It is believed that specific genetic changes may accompany the onset and progression of the disease. Dr. Andrew Holloway of the Peter Ma...

Tendency to hair loss inherited from the mother

...More androgen receptors in the scalp Probably the genetic variant results in more androgen receptors in the ... of the receptor which develops as a result of the genetic change is more stable and is not broken down so quickly. Both mechanisms can lead to the effect of t...

Gene therapy cures inherited liver disease in rats

...o long term effect. It does not become part of the genetic machinery of the cell and poses no risk of causing cancer, said Lee. "This approach would be applicable to many diseases where you are trying to put something back, targeting the liver," he said. He is hesitant to predict when the treatment can be ...

Master gene controls healing of skin in fruit flies and mammals

...ists and their colleagues have discovered that the genetic system controlling the development and repair of i...y grainyhead as the master gene that initiates the genetic chain reaction that results in cuticle repair. Wounds in mutant flies that lack the grainyhead gene ...

Infants with Rare Genetic Disease Saved By Cord Blood Stem Cells

Children with a fatal genetic disorder called Krabbe Disease can be saved and th...ated and saved more children with cancers and rare genetic diseases than any other center in the world ?147 children in all. The oldest Duke patient transplant...

Doing a spin with DNA

...staircase. The sequence of these base pairs stores genetic information. During cell division genetic material is copied and the enzymes responsible for this must be able to transcribe the base sequence...

Stanford gut check shows diversity of intestinal ecosystem

...rg took advantage of a technique that compares the genetic sequence of a molecule shared by bacteria and arch..., 16S rRNA, plays a role in the translation of the genetic code and thus is critical to the organisms. However, small variations in the 16S rRNA gene sequences...

wFleaBase: the Daphnia genome database

...ormatics tools. Over the coming year, preliminary genetic maps and the nearly complete genomic sequence of D...dly expand its content and to ultimately integrate genetic and functional genomic information with population-level responses to environmental challenges. ...

Unchecked DNA replication drives earliest steps toward cancer

...a disease of the genes, cancer is always rooted in genetic errors or problems in gene regulation. Scientists have identified some of the first genetic triggers for cancer as mutations in specific oncogenes or tumor suppressor genes. Full-blown tumors ...

Science study holds implications for gene therapy and stem cell biology

...ion in regards to the side effects associated with genetic engineering of stem cells. The study, whose lead author is Christopher Baum, MD, an adjunct associate professor of experimental hematology at Cincinnati Children's, is one of a family of studies on using disabled retroviruses as gene transfer vector...

Scientists generate patient-specific stem cells, Science study says

...cell lines was created by transferring the nuclear genetic material from a non-reproductive cell of a patient...ransfer" or SCNT. Next, oocytes with the patient's genetic material were allowed to grow to the blastocyst stage, an early stage of embryo development. Stem ce...

SuperLigands - a database of ligand structures derived from the Protein Data Bank

...cell lines was created by transferring the nuclear genetic material from a non-reproductive cell of a patient...ransfer" or SCNT. Next, oocytes with the patient's genetic material were allowed to grow to the blastocyst stage, an early stage of embryo development. Stem ce...

Mouse with designer liver has enhanced glucose tolerance, insulin response

...unctions in the liver, Feng used a highly advanced genetic engineering technology, called tissue-specific gene deletion, to create a mouse in which the Gab1 gene was deleted, or "knocked out", from the liver, and only the liver. Offsprings were termed "LGKO" for liver-Gab1 knockout mice. Dr. Feng’s laborato...

Retrovirus struck ancestors of chimpanzees and gorillas millions of years ago, but did not affect ancestral humans

...t of a retrovirus, a type of virus that copies its genetic information into the host's genome. Evidence sugge...t. "The reason retroviruses are so deadly, at the genetic level, is that they have a tremendous potential to mess up a gene and interfere with its expression,...

Important discovery about second most fatal cancer

...es, each with a different cause and behaviour. The genetic basis of this new syndrome is not known but it is speculated that affected families have a genetic predisposition to develop DNA methylation. There is already evidence that subjects with colorectal c...

Making Sure Sacred Sheep Don't Become Extinct

...y semen and embryos -- to make sure there's enough genetic material to reintroduce a species if necessary. Mu...east 50 different males to get a broad sampling of genetic diversity. If there were ever a need to totally regenerate the Navajo-Churro breed from the ARS col...

15-year hunt finds cause of pseudothalidomide syndrome

...ccessfully completed a 15-year-plus search for the genetic problems behind the very rare Roberts syndrome, wh... Hopkins. "Just within the last few years have the genetic techniques, the genomic information, and the computer analysis become powerful enough to find the ge...

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