Infants With Rare Genetic Disease Saved by Cord Blood Stem Cells
Children with a fatal genetic disorder called Krabbe disease can be saved and th...ated and saved more children with cancers and rare genetic diseases than any other center in the world ?147 children in all. The oldest Duke patient transplant...Defenseless plants arm themselves with metals
...to developing a "molecular toolbox" to provide the genetic information to develop plants to clean up polluted sites. Technologies developed at the center will be commercialized through a partnership with the Midwest Hazardous Substance Research Center, a U.S. Environmental Protection Agency regional hazardou...Yeast Network Prevents Damage By Oxygen Radicals
...linical symptoms of human diseases associated with genetic deficiencies of DNA damage responses." ...Genetically Modified Natural Killer Immune Cells Attack, Kill Leukemia Cells
...atient while in remission and then reinfused after genetic modification if the patient suffers a resurgence of the leukemia. "We look forward to seeing this strategy being added to the management of children with ALL," said Chihaya Imai, M.D., the postdoctoral student who did most of the work on this projec...Mystery Blood Vessel Disorder Implicated In 'Mini' Strokes
...GENIC study) to try to determine which vascular or genetic factors contribute to the syndrome. They will also attempt to replicate their MRI data in an autopsy study of patients who died with dolichoectasia. ### Article: "Intracranial Arterial Dolichoectasia and Small-Vessel Disease in Stroke Patients," by......s. This would facilitate studies of the roles that genetic background, environment and lifestyle play in susceptibility to cancer and pathogenesis of particular cancers. Such studies would be easier to conduct if pediatric cancer units are created in resource-poor nations and if their development promotes in...Same-Sex Mating Discovered in a Toxic Fungus
... mating types, a and alpha, determined by a single genetic region, or locus. Most fungal isolates taken from... the fusion of cells followed by meiosis, enabling genetic exchange between members of the same sex, they reported. Meiosis is the process whereby cells divid...Genetic defects give the immune system the green light to attack the pancreas
Scientists at Joslin Diabetes Center have found genetic regions that, when defective, allow the immune sys...and Tetsuya Yamagata, M.D., Ph.D, from Japan. The genetic defect keeps the body from properly dealing with “errant?immune cells that it normally eliminates by...Biologists discover why 10% of Europeans are safe from HIV
...known for some time that these individuals carry a genetic mutation (known as CCR5-delta32) that prevents the virus from entering the cells of the immune system but have been unable to account for the high levels of the gene in Scandinavia and relatively low levels in areas bordering the Mediterranean. They...UNC launches study of liver injury caused by drugs
...alysis based on blood samples to identify possible genetic risk factors for such liver injury. "Once a drug has been associated with severe liver injury, physicians are understandably hesitant to prescribe it, even if it may provide the best benefit for that patient," said Dr. Mark Russo, assistant professo......known for some time that these individuals carry a genetic mutation (known as CCR5-delta32) that prevents the virus from entering the cells of the immune system but have been unable to account for the high levels of the gene in Scandinavia and relatively low levels in areas bordering the Mediterranean. They...Used in a new way, RNA interference permanently silences key breast cancer gene
...fect is achieved with RNAi before the tiny bits of genetic material are become inactive as the cell population continues to expand. "We are a long way from using this technique in patients, but this study shows that that it may be possible to use RNAi in more than just experiments that silence genes tempora...Bioelectronic ‘signatures?hold key to DNA mutations
...pplications such as the diagnosis and treatment of genetic diseases, detection of infectious agents and relia... similar to a hand-held glucose monitor for future genetic testing,?Wang says. “The electronic detection of DNA is a thing of beauty. You can make it small, lo...Different microarray systems more alike than previously thought
...pression of thousands of genes at once to create a genetic "fingerprint," suggests these different microarray technologies are more alike than once thought. Published in the May 2005 issue of Nature Methods, the study provides new hope that the mounds of information generated by these systems might actually...New understanding of DNA repair may pave way to cancer treatments
...n intracellular process that prevents formation of genetic mutations, including those that lead to cancer. "This is the first time we've seen a protein which has been implicated in gene regulation possess an independent function--in DNA repair--while both functions are uncoupled from one another," said Rona...New tumor-suppressor gene discovered
...or suppressor to control tissue growth. The team's genetic and biochemical studies will be published in the 1...n mats gene to tumor-plagued flies known to have a genetic defect in their mats gene, then found that tumors no longer developed within this line of flies in i...Biomarkers isolated from saliva successfully predict oral and breast cancer
...Cancer Research, the UCLA scientists reported that genetic "biomarkers" isolated in saliva predicted oral squ...methods to identify, collect, preserve and amplify genetic material and proteins. In this study, the UCLA team found they could isolate messenger RNA from sal...Cooperation is key—a new way of looking at MicroRNA and how it controls gene expression
...NA known as microRNA and their relationship to the genetic transcripts known as messenger RNA (mRNA). All ge...these mRNA transcripts is essential for control of genetic expression. In the latest issue of the journal Cell, the Scripps Research team, led by Immunology P...FDA Works To Speed The Advent Of New, More Effective Personalized Medicines
...ors will eventually be able to analyze a patient's genetic profile and prescribe the best available drug ther...notyping Test, which will enable physicians to use genetic information to select the right doses of certain medications for cardiac, psychiatric diseases and c...... into allies in the fight against cancer. Through genetic engineering, viruses are being re-programmed to take advantage of their natural abilities to infiltrate, commandeer, replicate and destroy, but only in tumor cells and not surrounding healthy tissue. Several of these "oncolytic" (cancer-killing) vir...