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Tag: "genes" at biology news

Compounds in plastic packaging act as environmental estrogens altering breast genes

...f the breast has specific differentially expressed genes that provide a genomic signature according to the ...increase in protein production governed by various genes at increasing ages from 21 to 100 days." These included proteins regulating cell proliferation and ...

Building a human kinase gene repository

...equence information of all identified human kinase genes and have built a gene repository for this gene class. Their work is described in the online early edition of Proceedings of the National Academy of Sciences and demonstrates uses of the collection in cellular and biochemical assays. Kinases are an i...

UCSD research reveals mechanism involved with type of fatal epilepsy

... linked to the disease. Recessive mutations in two genes have been shown to cause Lafora disease. The genes encode the proteins laforin and malin, but the molecular mechanism defining how loss of laforin or m...

Multiple-drug resistant gene expression pattern predicts treatment outcome for pediatric leukemia

...ehensive genetic screening technique to search for genes that are differentially expressed in ALL cells tha...peutic agents. The researchers identified several genes that were differentially expressed in ALL cells that exhibited de novo cross resistance to four wide...

Migratory songbirds have a specialized night-vision brain area

... brain structures for the active expression of two genes called ZENK and c-fos that signal activity in a particular brain region. The researchers found that the night-migratory species showed strikingly high activity in a particular cluster of cells located adjacent to a known visual pathway. According to...

NSAID drug protects against intestinal tumors in mice, despite poor diet and gene losses

...n cancer, they do illustrate the interplay between genes and common nutritional and medicinal agents in dev...ugh the mice were missing two key tumor suppressor genes (p27 and APC) and were fed a diet high in fat and low in calcium and vitamin D. "It appears that p2...

Doctors closer to using gene analysis to help trauma patients

...e how they were able to consistently analyze which genes are active in patients with serious infections or ... the end, scientists could see dramatic changes in genes turning on and off in trauma victims compared with healthy people. Among the trauma patients, resear...

Study reveals candidate targets for anti-retroviral therapeutics

...of new antiviral targets an urgent necessity. Host genes required to support the replication of HIV are a p...vel targets, but relatively few appropriate target genes have been identified in animal cells thus far. A new study, conducted by Dr. Suzanne Sandmeyer and c...

Signs of aging: Scientists evaluate genes associated with longevity

...e, scientists have identified dozens of additional genes that are crucial for longevity. "Aging is a comple...Wilson. "It is commonly believed that a variety of genes and metabolic pathways contribute to the deterioration of cells, tissues and organisms during aging....

Secret of smallpox's success may lead to bioterror cure

...enal of weapons against disease. Antigen-eliciting genes from hard-to-treat viruses such as HIV could potentially be added to the mutant vaccinia virus, which would draw the immune system's attention to the target virus's proteins, thus creating a strong immune response to the target virus. Though perhaps ...

Disease progression model of pancreatic cancer developed by Penn researchers

... colleagues, engineered mice to express two mutant genes commonly associated with pancreatic cancer: Kras, an oncogene, and p53, a well-studied tumor suppressor. The investigators linked physiological, cellular, and genomic changes due to mutations in Kras and p53 in the mice to changes similar to that obs...

The biggest family tree ever

...ll into disuse, the information stored in people's genes persists. Cusanovich had his own DNA analyzed, which helped him trace his family to a time "when the crusaders were rolling through the Middle East." Many people conduct genealogical research, said Cusanovich, a UA professor of biochemistry and mole...

Tendency to hair loss inherited from the mother

...hair loss. However, up to now it was unclear which genes are involved. The researchers in the team headed b...from the volunteers they then looked for candidate genes ?and eventually discovered them: in their initial step they succeeded in narrowing down the search t...

Gene therapy cures inherited liver disease in rats

...of other disease that occur because of the lack of genes in this area of the cell. The viral vector itself is important because it has no long term effect. It does not become part of the genetic machinery of the cell and poses no risk of causing cancer, said Lee. "This approach would be applicable to man...

Master gene controls healing of skin in fruit flies and mammals

...gene called grainyhead that activates wound repair genes in the cells surrounding an injury in the cuticle of a fly embryo. These wound repair genes then regenerate the injured patch of cuticle. In a separate study published in the same issue of Sc...

wFleaBase: the Daphnia genome database

...ch program to create the resources needed to study genes that affect ecological and evolutionary success in...ents based on sequence similarities with eukaryote genes of known function. wFleaBase aims to serve a large ecological and evolutionary research community. O...

Unchecked DNA replication drives earliest steps toward cancer

...erating process leads to an accumulation of mutant genes in the cell and, eventually, cancer. A report on the new findings appears in the April 14 issue of Nature and is featured on the journal's cover. "Cancer progression is driven by these mutations," explains Thanos D. Halazonetis, D.D.S., Ph.D., prof...

Gene keeps neural cells on correct developmental path

...rences among cell types arose from various sets of genes switched on inside developing cells. Then, studies...lack a protein that permanently turns off neuronal genes in the rest of the body's cells. Now, it turns out that precursor nerve cells contain that same rep...

Science study holds implications for gene therapy and stem cell biology

...d to leukemia in mice, because several "signaling" genes were activated that worked in concert to cause dis...e question left: What happens if only one of these genes is activated in a stem cell? This question is addressed in the newly published Science study. Resea...

To Stop Evolution: New Way Of Fighting Antibiotic Resistance Demonstrated By Scripps Scientists

...ars, Romesberg has led an effort to understand the genes that drive evolution, an innovative way of thinkin...per in a scientific journal that discussed certain genes that "make mutations," as he put it. When these genes are deleted from cells, the cells lose their a...

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