Synthetic molecule causes cancer cells to self-destruct
...ategies are preferential to therapies that rely on general cytotoxins, the researchers say, and could be the future of anti-cancer therapy. ...Everything in its place: Researchers identify brain cells used to categorize images
...sing motion-based categories or if it plays a more general role in categorizing other types of visual stimuli, such as shapes, as well." Freedman is optimistic that research of this type will eventually contribute to a better understanding of neurological diseases and disorders. "Understanding how the brai...Viral genetic differences are possible key to HIV dementia
...ed with HIV, this study may also contribute to our general understanding of viral encephalitis," or brain inflammation caused by other viruses. "These results suggest that specific features of viral components themselves, and not just the immune response to viral infection, may be responsible for direct dama...Finding a better way to make biodiesel
...'t take them away from home." Larry Breeding, the general manager of biodiesel operations for the West Central Cooperative, said the technology shows promise for improving the efficiency of biodiesel production. But he said it still needs to be tested at larger and larger scales to see if the economic benef...Mechanism identified for promising neurological drug
...nson says the results have implications beyond the general principle that "it helps to know how a drug is working." One is potentially negative. "In blocking PARP-1, you block DNA repair," he cautions. "That will likely be true of minocycline. And in blocking DNA repair you conceivably increase the risk of ...Genetic tug of war determines sexual differentiation
...n in a turtle that she hopes can shed light on the general issue of sex determination in vertebrates. ...DOE JGI finishes 100th microbial genome
... encoded in their DNA sequence. On May 23, at the general meeting of the American Society of Microbiology (ASM), the U.S. Department of Energy Joint Genome Institute (DOE JGI) will announce that it has finished the sequence of100 microbial genomes and released this information for the benefit of the global ...Montreal researchers identify defects of immune cells
...ion and lead to weight loss, threatening patients' general health and well-being. Of added concern, treatment of candidiasis in these patients is often complicated by strains of Candida albicans resistant to conventional antifungal therapies. The research project was carried out jointly by Dr. Louis de Repen...Wild bees and the flowers they pollinate are disappearing together
...ey species or a few focal sites. To test for more general declines, an international team of researchers from three UK universities (Leeds, Reading and York) and from the Netherlands and Germany compiled biodiversity records for 100s of sites, and found that bee diversity fell in almost 80% of them. Many be...Can biological traits predict diversification rates in birds?
...milies with high seasonal dispersal rates and very general feeding patterns also had the highest species diversification rates. ...How HIV 'exhausts' killer T cells
...the PD-1 pathway occurs during the immune system's general response to viral infection. In test tube studies, the researchers showed that higher PD-1 expression was associated with more severe functional "exhaustion" of HIV-specific killer T cells. The studies clearly demonstrated that the greater the ...A new tool against brain disease
...the PD-1 pathway occurs during the immune system's general response to viral infection. In test tube studies, the researchers showed that higher PD-1 expression was associated with more severe functional "exhaustion" of HIV-specific killer T cells. The studies clearly demonstrated that the greater the ...Survivors of childhood polio do well decades later as they age
...ly selected a group of 50 polio survivors from the general population of Olmsted County, home of Mayo Clinic, and followed them for 15 years. The average age of participants at the study's start was 53, and the patients were an average of 40 years past their childhood experience with polio. The researchers m...Gene first linked to rare disease may trigger skin cancer, other tumors
...develop multiple, benign skin tumors may be a more general player in cancers found throughout the body, accor...s wrote. "This strongly suggests that CYLD plays a general role as a tumor suppressor, which is in agreement with its ubiquitous expression pattern and with a ...New findings offer more complete view of breast cancer gene mutations in US population
...the prevalence of BRCA1 and BRCA2 mutations in the general U.S. population. Among white and African American women ages 35 to 64, the prevalence of BRCA1 mutations is 0.06 percent and the prevalence of BRCA2 mutations is 0.4 percent, the researchers estimated. "These findings from our large, population-bas...A protein complex that untangles DNA
...r level. This will bring us one step closer to the general goal ?a summary of the many mechanisms that collaborate to maintain our genetic stability", says Camilla Sjögren. ...Ultra low-dose estrogen shown safe for post-menopausal women
...n had no ill effects on the cognitive abilities or general health of older women over the course of two years. "This is exciting. It shows that women can take estrogen safely," observes lead author Kristine Yaffe, MD, chief of geriatric psychiatry at SFVAMC and associate professor of psychiatry, neurology,...New roles for growth factors: Enticing nerve cells to muscles
...atory, "but that piece by piece, we are uncovering general principles that ensure that the developing nervous system establishes proper neuronal connections." Understanding how axons find their destinations may help restore movement in people following spinal cord injury, or those with motor neuron disease...Salk and Stanford teams join forces to reveal two paths of neurodegeneration
...pruning and injury from flies to mammals points to general mechanisms which are most likely also at work in the human nervous system. Both investigators believe that these and related studies can help in the development of therapies that preserve injured axons and restore proper connections. Other researche......RNA molecule in its LAT gene. "MiRNA may be a more general mechanism that latent viruses use to remain alive in the host cell," suggests Fraser. Present treatments of HSV-1 rely on acyclovir-based drugs that target the viral polymerase and inhibit viral DNA replication during the acute infection. However,...