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Tag: "gene" at biology news

Genomic Analysis Uncovers New Targets for HIV Vaccine

...rnational team of researchers has identified three gene variants in the DNA of 486 people infected with HI...cines. In the new analysis, patients with specific gene variants in key immune system cells appear to be much better at controlling the proliferation of the...

Scratch no more: Gene for itch sensation discovered

...of Medicine in St. Louis have identified the first gene for the itch sensation in the central nervous syst...Ph.D., found that laboratory mice that lacked this gene scratched much less than their normal cage-mates when given itchy stimuli. The laboratory experimen...

One species, many genomes

...ies, or cannot be found at all. Almost every tenth gene was so defective that it could not fulfill its nor...uences. "That even in a minimal genome every tenth gene is dispensable, has been a great surprise," admits Weigel. Detailed analyses showed that genes for...

Identified main genetic variants involved in response to HIV

...control of viral infection. Results point to two gene variants related to the immune system. More precis...ed in immune damage of patients, particularly in a gene encoding a protein which seemingly participates in viral replication, and is also located in chromos...

Common cancer gene sends death order to tiny killer

...s at Johns Hopkins have discovered one way the p53 gene does what it's known for—stopping the colon cancer... containing p53. It turned out that the miR-34a gene is turned on by p53, and in fact, experiments demonstrated that p53 binds directly to the genetic ma...

Researchers discover inherited mutation for leukemia

Researchers have discovered the first inherited gene mutation that increases a person's risk for chroni... second kind of change occurs later that turns the gene off altogether, leading to leukemia. This latter alteration is a chemical change that is not inherit...

Enzyme delivered in smaller package protects cells from radiation damage

...Stanford University, have developed a new, smaller gene therapy vector that may be effective in delivering...Based on previous studies showing that intravenous gene therapy delivery of the enzyme manganese superoxide dismutase (MnSOD) could protect mice from whole ...

Cells re-energize to come back from the brink of death

...is is triggered by a variety of factors, including gene mutations that can make the cell become cancerous. During apoptosis, the membrane covering the cell’s mitochondria develop holes and leak a molecule called cytochrome c, which triggers the activity of enzymes called caspases. In turn, caspases trigge...

Brain inflammation may be friend, not foe, for Alzheimer's patients

... class of viruses known as lentiviruses for use in gene therapy. The team used a lentivirus to boost levels of IL-1 beta in select brain regions of its engineered mouse, then applied the technology in mice specially designed to develop Alzheimer’s disease. The mice developed normally for six months. Th...

Gene therapy delivery of nerve growth factors reverses erectile dysfunction in animal model

...tile dysfunction, or ED, that were injected with a gene therapy vector containing either of two nerve grow...chool of Medicine, researchers inserted either the gene for the glial cell line derived neurotrophic factor (GDNF) or the GDNF family ligand (neurturin) int...

Research team identifies new Alzheimer's gene

...efore has enabled researchers to identify a common gene that appears to increase a person’s risk for devel...nd their collaborative partners, suggests that the gene — called GAB2 — modifies an individual’s risk when associated with other genes, including APOE4. The...

Largest synthetic gene ever built offers insights into anti-malarial drug resistance

... construct, and then express in yeast, a protozoan gene that contributes to such resistance. And it was no small feat. The gene they laboriously constructed over a two-year period is believed to be the largest synthetic one ever...

Loss of stem cells correlates with premature aging in animal study

...versity of Pennsylvania have found that deleting a gene important in embryo development leads to premature aging and loss of stem cell reservoirs in adult mice. This gene, ATR, is essential for the body’s response to damaged DNA, and mutations in proteins in the DNA damage response underlie certain types ...

In mice, drug protects against diabetes and atherosclerosis

... has been observed in mice and humans carrying the gene variant. The lipid chaperone protein aP2 acts a.... While the scientists could not knock out the aP2 gene in humans, they could focus on subjects in the large Nurses' Health Study and the Health Professiona...

New study finds genetically engineered crops could play a role in sustainable agriculture

... world, involving corn and cotton plants with a Bt gene inserted for its insecticidal properties. The research was conducted by scientists at the National Center for Ecological Analysis and Synthesis (NCEAS) at the University of California, Santa Barbara, The Nature Conservancy, and Santa Clara Universit...

Newly found sensing system enables certain bacteria to resist human immune defenses

... that cause plague and salmonellosis—a sensory and gene regulation system named PhoP/PhoQ protects invadin...as three parts: apsS, the sensor region; apsR, the gene regulation region; and apsX, which has an unknown function that Dr. Otto’s group is investigating. S...

Sun exposure early in life linked to specific skin cancer gene mutation

Skin cancers often contain different gene mutations, but just how these mutations contribute...cifically increase the risk of melanomas with BRAF gene mutations. A different mutation, on the NRAS gene, was found in patients who had sun exposure later ...

Breakthrough developments in rheumatoid arthritis reported

...mmune process. In fact, in 2004, they identified a gene called PTPN2 that confers a two-fold risk for rheu... arthritis by 30 percent. (The paper reporting the gene is in press.) In collaborations with other scientists worldwide, Dr. Gregersen has also been ab...

'Lucky 13' as new gene discovery offers further hope for childhood blindness

An international research team has discovered a gene that, when mutated, causes one of the most common ...ls that "see" light. The finding, the thirteenth gene to be linked to Leber’s congenital amaurosis (LCA), comes at a time of hope for the people born with...

U-M researchers discover gene switched off in cancer can be turned on

A gene implicated in the development of cancer cells can ...arget these genes. U-M researchers found that a gene called Brahma, or BRM, is silent – but not missing – in some cancer cells. By exposing the BRM prote...

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