Plant defenses prompt bacterial countermeasure in the form of 'island' DNA excision
...e process of infecting a plant can shift molecular gears by excising specific genes from its genome to overcome the host plant's specific defenses. Throughout evolution ?in the wild and in crops cultivated by humans ?plants have developed systems for resisting the attack of microbial pathogens, while thes...Greasing interferon's gears may pave way to greater therapeutic benefits, fewer side effects
...ouis. "Essentially, we found a way to grease the gears that drive the interferon signal," says Michael J. Holtzman, M.D., the Selma and Herman Seldin Professor of Medicine and director of the Division of Pulmonary and Critical Care Medicine. The researchers modified the structure of a protein called St...Wisconsin scientists discover a master key to microbes' pathogenic lifestyles
...onment. And as soon as they do, they rapidly shift gears and assume the guise of pathogenic yeast, causing such serious and sometimes deadly afflictions as blastomycosis and histoplasmosis. But how these usually bucolic fungi undergo such a transformation to become serious pathogens has always been a puzz...Clock molecule's sensitivity to lithium sheds light on bipolar disorder
...n circadian clock and metabolism. Proteins are the gears of the clock, and not much is known about what reg...d human cells. "It's like pulling a pin out of the gears of the clock, to allow them to turn in a synchronized manner," says Lazar. Lithium blocks this acti...Gene that makes people 'early to bed and early to rise' demystified
... from the fruit fly, mouse and now human about the gears and how they are working, we're getting closer to a 'button' that might be able to do that." ......lantic deep water partner) are capable of shifting gears very suddenly, but until now it wasn’t clear how this occurred. Using a combination of modern observations, numerical models and palaeoclimate data scientists are increasingly realising that salt is the key. Their results reveal that a build up of...