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Tag: "functioning" at biology news

Cells re-energize to come back from the brink of death

...D. GAPDH appears to prevent CICD by supporting the functioning of the mitochondria and triggering the activity of certain genes that prevent or repair cell damage. The findings also suggest that the increase in GAPDH provides energy to increase autophagy—the process by which a cell “chews up” debris and broken c...

Longer treatment benefits sleep apnea patients

... widely accepted assessment tools, and for daytime functioning using a standardized test before treatment and after three months of CPAP therapy. The findings suggest that most patients should use CPAP for at least 7.5 hours each night to realize the greatest possible benefits of therapy. "Relationship Betw...

How brain pacemakers erase diseased messages

...'s team created a mathematical model of a normally functioning brain cell. The researchers then gave the model neuron the pathological pattern of activity seen in people with tremors, assembled a group of these model cells and watched what would happen when the cells were electrically stimulated at various rates...

DNA repair proteins monitored at double-strand break

...aling processes triggered by the break. "A lack of functioning ATM causes ataxia-teleangiectasia, a disease that ...nd expose the area to repair proteins; the loss of functioning ATM and NBS1 blocks this important process. The team also showed that both NBS1 and ATM are needed t...

Thymus transplants gives hope to babies with fatal immune disease

...on. DiGeorge anomaly is marked by the lack of a functioning thymus, a gland that is responsible for "teaching" immune system cells known as T cells how to attack and fight off infections. Babies with DiGeorge anomaly also can have a range of problems including heart defects and unusual facial features. Howeve...

Gene thought to assist chemo may help cancer thrive

...g cancer - namely, developing drugs to disable the functioning of this gene in the tumors of patients undergoing ...gher mortality rate of patients whose tumors had a functioning p53. If we are correct, inhibiting p53 in tumors being treated with chemotherapy may substantially i...

Researchers develop marker that identifies energy-producing centers in nerve cells

...ht up brain cells that are critical for the proper functioning of the central nervous system. This fluorescent marker protein may shed light on brain cell defects believed to play a role in various neurological diseases. The researchers describe how this marker works in mice in the December 20, 2006, issue of Th...

A 'traffic light' for neurons means 'go' for improving brain research

...could be useful in teasing out the largely unknown functioning of healthy brains. "One day we'd like to be able to understand the organization of the brain," Zhang says. "How do different types of cells communicate with each other to carry out very complex things like emotion or how people make decisions?" ...

Major gene study uncovers secrets of leukemia

...to prevent progenitors from changing into normally functioning lymphocytes. Normally, the body eliminates differentiated B lymphocytes that have failed to assemble the right genes to make effective antibodies against the specific target they are supposed to attack. However, if these defective B lymphocytes do no...

Stem cells act through multiple mechanisms to benefit mice with neurodegenerative disease

...Both diseases are marked with deficient Hex enzyme functioning and are among a known group of about 50 diseases rooted in the inability to metabolize lipids or other materials. While Sandhoff and Tay-Sachs are relatively rare, one person in 5,000 is affected by a disease that falls into a category of lysosomal s...

A new study of living cells could revolutionize the way we test drugs

...a kind of ‘cellular cardiogram? allowing the daily functioning of the cell to be monitored in a similar way to a cardiograph showing the workings of a human heart. With funding from the Engineering and Physical Sciences Research Council (EPSRC), Professor Andre Geim at the University of Manchester and his tea...

Researchers discover gene crucial for nerve cell insulation

...affects the normal copy of the gene as well as the functioning of other genes, resulting in peripheral neuropathy...a single mutant copy of the EGR2 gene disrupts the functioning of the normal EGR2 gene, leading to a disorder of the nervous system. In many genetic conditions,...

Is there a pilot in the insect?

...optic flow sensors. The team patiently decoded the functioning of these neurons using ultra-fine microelectrodes (with a diameter of a thousandth of a millimeter) and a specially designed microscope. They then produced an electronic microcircuit based on this principle. The most recent version weighs only 0.2 gr...

Researchers create artificial enzyme that mimics the body's internal engine

...ll three active sites are essential for the proper functioning of the enzyme. According to Devaraj, the new laboratory techniques developed in this experiment may have applications for research involving other enzymes. Understanding what makes CcO so efficient in reducing oxygen to water may even be useful to...

Carnegie Mellon University research shows how sensory-deprived brain compensates

...her side. "These findings show us that a fully functioning set of whiskers on one side of the body dramatically inhibits the ability of a single whisker to remodel the brain," said Barth. "This finding suggests that we could boost the brain's plasticity if we 'turn off' sensory input from the opposite side o...

Chemical switch triggers critical cell activities

...t biochemical activities that keep cells alive and functioning normally." Schulman, a Howard Hughes Medical Institute (HHMI) investigator, is senior author of the Nature report. Scientists already knew that E1 momentarily juggles two NEDD8 molecules at once, holding them in two different "hands." They also k...

Penn researchers replace organ in adult mice using 'single-parent' stem cells

...f chromosomes - one from each parent - to create a functioning embryo.According to McLaughlin, this is because mammalian embryos rely on a process called genomic imprinting, where cells will read certain genes from only one parent. Imprinting failures could lead to the death of an embryo and are frequently asso...

Study uncovers a lethal secret of 1918 influenza virus

...tics process that enables scientists to make fully functioning viruses. "In 1918, the existence of viruses had barely been recognized. In fact, the influenza virus wasn't identified until 1933. Thanks to recent technological advancements, we are now able to study this virus and how it wreaked havoc around th...

Scientists uncover new target in cancer mutation puzzle

...vement. The experiments showed that when p53 is functioning properly it appears to be able to suppress the Ras signals to Rho, and thus shut down the movement of cancer cells. This was a previously unknown mechanism of action for the p53 gene. Someday Rho may prove to be an attractive target for therapy be...

Reactivated gene shrinks tumors

... p53 controls the cell cycle. In other words, when functioning properly, it activates DNA repair mechanisms and prevents cells with damaged DNA from dividing. If DNA damage is irreparable, p53 induces the cell to destroy itself by undergoing apoptosis, or programmed cell death. When p53 is turned off by mutat...

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