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New Study from Affymetrix Laboratories Points to Changing View of How Genome Works

...d a high-resolution scan of structure and function for nearly 30 percent of the human genome sequence. In...d regulated," said Thomas Gingeras, Vice President for Biological Research at Affymetrix and senior author of the Science manuscript. "These data point us ...

First-ever Compounds To Target Only Metastatic Cells Are Highly Effective Against Breast, Prostate, And Colon Cancers

...tumor at lower doses, too, with fewer side effects for the patient," Dr. Huang said. Until now, agents that specifically target metastatic cells have remained elusive. However, a new avenue of research opened up when Dr. Huang's team noticed that the Streptomyces bacterium -- the bug that gives us the a...

Discovery of key protein's shape could lead to improved bacterial pneumonia vaccine

...lly respond to carbohydrates. Pneumococcusvaccines for children must instead be modified by binding those...so complex that they cancarry carbohydrate targets for only a few specific strains of pneumoniabacteria,?Tuomanen said. “So children are always under-prote...

Critical role in programmed cell death identified

...achinery of worms and mammals, opening new avenues for studying and targeting a process vital to developm... programmed cell death, or apoptosis, is essential for life; it's needed for nervous system development and it keeps the body up and running. Miscues and f...

Study: Soap And Water Work Best In Ridding Hands Of Disease Viruses

...sted what happened when people cleaned their hands for only 10 seconds, Sickbert-Bennett said. That repre...Previous studies have had people clean their hands for 30 seconds or so, but that’s not what health-care workers usually do in practice, and we wanted to t...

New comparative toxicogenomics database

...lly respond to carbohydrates. Pneumococcusvaccines for children must instead be modified by binding those...so complex that they cancarry carbohydrate targets for only a few specific strains of pneumoniabacteria,?Tuomanen said. “So children are always under-prote...

Taking Aim With Nanoparticle PEBBLEs

...anoscale polymer beads known as Photonic Explorers for Biomedical use with Biologically Localized Embeddi...nitor cellular processes, PEBBLEs now hold promise for diagnosing and treating cancer, said Raoul Kopelman, who is the Kasimir Fajans Collegiate Professor ...

ASU researchers finds novel chemistry at work to provide parrot's vibrant red colors

...escribing on a molecular level what is responsible for their bright red feathers. The work casts a new light on what is chemically responsible for the colors of birds, and defies previous assumptions and explanations for color variations in parrot...

Elephants imitate truck noises, other animals

...supports the idea that vocal learning is important for maintaining individual social relationships among ...ds, and bats. Researchers from the Amboseli Trust for Elephants in Kenya, the Woods Hole Oceanographic Institution and the University of Vienna studied so...

Genetically modified natural killer immune cells attack, kill leukemia cells

...rove the outcome of children who receive treatment for acute lymphoblastic leukemia (ALL) or other blood ...until now slowed development of NK-based therapies for ALL, according to Dario Campana, M.D., Ph.D., a member of St. Jude Hematology-Oncology and Pathology...

UCSD researchers maintain stem cells without contaminated animal feeder layers

...ells in a continuous undifferentiated state, ready for research. Undifferentiation means the stem cells h...creatic cells. Human embryonic stem cells cultured for several weeks under these conditions showed no change in cell form and structure. The team then elim...

Transport System Smuggles Medicines Into Brain

...escribing on a molecular level what is responsible for their bright red feathers. The work casts a new light on what is chemically responsible for the colors of birds, and defies previous assumptions and explanations for color variations in parrot...

Scientists develop new color-coded test for protein folding

...we've developed is a simple and inexpensive sensor for determining when a protein changes its conformatio...e biomedical researchers a fast, affordable method for detecting antibodies and other disease-related proteins. Acid and base In their experiment, Zare, p...

Placenta Is A Rich Source Of Blood Stem Cells

...earn how to grow blood stem cells in large numbers for clinical application.'' Blood stem cells are used...ion of the developing aorta. No role was suspected for the placenta, which has been seen as simply a place for nutrient exchange and waste removal between ...

Probing The Promise And Perils Of Nanoparticles

...llaboration with other researchers at U-M's Center for Biologic Nanotechnology, Banaszak Holl's lab has b...ess of a human hair. Dendrimers have shown promise for precisely delivering drugs to their targets inside the body, but high concentrations of these nanopa...

Open microfluidic and nanofluidic systems

...size of a computer chip. An essential prerequisite for such labs are appropriate microcompartments for the confinement of very small amounts of liquids and chemical reagents. Directly accessible surface ...

Nanogen Issued Patent for Electronic Microarray With Memory

...s of a microarray. The patent also covers a method for storing the value of the voltage associated with e...e company's second generation multi-purpose system for developing and performing molecular diagnostic tests. Using local memory circuits provides for prec...

Researchers discover molecule that causes secondary stroke

...es the brain carries off wastes and exchanges them for nutrients at what's called the blood-brain barrier," Dr. Clark says. "After a hemorrhagic stroke, however, toxins given off by the brain bleed contribute to the development of specific molecules that later causes the constricting vasospasm." A resear...

Study shows nanoshells ideal as chemical nanosensors

...s beendifficult to control, predict, and reproduce for practical sensingapplications. Now, Rice researche...cible enhancements of this effect, openingthe door for new, all-optical sensing applications."Not only did we find that nanoshells are extremely effective ...

Gene Vaccine Protects Mice Against Development Of Her2/neu Breast Cancer

...ive but still able to function asa delivery system for proteins from the cancer cells that are to betargeted by the animal’s immune system.The basis for this new vaccine is an RNA virus called VEE, forVenezuelan equine encephalitis, which in its natural...

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