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Enzyme shown to help protect genomic stability

... gene transcription. Scientists believe one reason for this broad gene silencing is the vital need for genomic stability, for protection against unwanted recombinations of genetic material or other disru...

BRCA1 causes ovarian cancer through indirect, biochemical route

...owever, had been harder to pin down. "We've known for a long time that ovarian cancer is associated with...ancy or oral contraceptive use are at highest risk for developing sporadic ovarian cancer," Dubeau explains. "So we had some clues that the cells that cont...

Scientists decipher genome of fungus that can cause life-threatening infections

.... "Notonly have we established a genomic platform for the further study ofthis increasingly important pa..." says BrendanLoftus, a scientist at The Institute for Genomic Research (TIGR) who isthe first author of the Science paper. "Although the two Cryptococcuss...

Poplar trees redirect resources in response to simulated attack

...e know that plants respond defensively to attacks, for example, by producing chemicals that kill off the ...that plants also respond by building up tolerance, for example by putting aside more carbon into storage so it will be available to help the plant spring b...

Purdue proves concept of using nano-materials for drug discovery

...University have built and demonstrated a prototype for a new class of miniature devices to study syntheti...s in an effort to speed the discovery of new drugs for a variety of diseases, including cancer. The researchers created a chip about one centimeter square...

Scientists discover the cellular roots of graying hair

...ce within the hair follicle,where they are useless for coloring hair.The new findings won’t lead to a sci...of pigment stem cells, since melanoma is dangerous for the oppositereason –melanocytes proliferate uncontrollably to form tumors and arehard to kill with t...

Researchers identify target for cancer drugs

...ied a component that researchers have been looking for since 1996," says Whitehead Associate Member David...n size. mTOR has been widely studied as the target for the immunosuppressant drug rapamycin (in fact, mTOR is an acronym for "mammalian target of rapamycin...

Plant hemoglobins: Oxygen handlers critical for nitrogen fixation

...o ammonia, which is subsequently used by the plant for growth and colonization of nitrogen-poor soils. Symbiotic nitrogen fixation is important for sustainable agriculture and contributes millions of tons of reduced nitrogen to crops and pastures e...

Fundamental Finding Yields Insight into Stem Cells, Cancer; Opens Door to Drug Discovery

...ce within the hair follicle,where they are useless for coloring hair.The new findings won’t lead to a sci...of pigment stem cells, since melanoma is dangerous for the oppositereason –melanocytes proliferate uncontrollably to form tumors and arehard to kill with t...

Scientists rid stem cell culture of key animal cells

... thought to be a source of potential contamination for the therapeutically promising cells. The new find...ens tainting human stem cell lines poses a problem for the safe clinical use of many, if not all, of the current cell lines now in use. Until now, scienti...

Essential mangrove forest threatened by cryptic ecological degradation

... are ecologically and socio-economically important for local people in tropical countries on all continen...of such changes should be adopted and is essential for the prevention of further mangrove degradation. F. Dahdouh-Guebas, S. Hettiarachchi, D. Lo Seen, O....

Weizmann Institute scientists develop a new approach for directing treatment to metastasized prostate cancer in the bones.

...ce within the hair follicle,where they are useless for coloring hair.The new findings won’t lead to a sci...of pigment stem cells, since melanoma is dangerous for the oppositereason –melanocytes proliferate uncontrollably to form tumors and arehard to kill with t...

Experiments provide proof of how traveling in groups protects insects

...y such groups of insects form has mystified humans for thousands of years. One firmly held belief was that God was punishing men and women for their sins. A more recent, scientific theory has been the "safety-in-numbers" idea -- that the small...

Protein Packages Found To Activate Genes; May Be What Regulates Development And Disease

...packaging of two entire human chromosomes was done for the first time. Besides Bernstein, the investigat... protein packaging. These proteins act like spools for the long strings of DNA that contain our genes and form chromosomes. The researchers studied chemica...

First 'atlas' of key brain genes could speed research on cancer, neurological diseases

...r pain: He and his students are screening theatlas for transcription factors that regulate development of theneurons that generate the severe pain that is a common symptom ofmetastatic tumors.The research was funded by the Charles Dana Foundation, the NationalInstitutes of Health, and individual fellowsh...

New research questions basic tenet of neuron function

...d that the same synaptic vesicles were responsible for releasing neurotransmitters in both modes. Howeve...istinct types of synaptic vesicles are responsible for the two different modes of neurotransmitter release ?one type of vesicle for spontaneous release, an...

Vital step in cellular migration described by UCSD medical researchers

...the cell. These protrusions serve as tractor sites for migration as the cell moves toward its intended target. If Rac were active throughout the cell, it would extend protrusions in all directions, in essence keeping the cell in one place. Until now, researchers have had limited understanding of the mol...

U-M scientists find genes that control growth of common skin cancer

... as the Hhpathway is effectively inhibited.Funding for this research was provided by grants from the NationalCancer Institute and the National Institute of Arthritis andMusculoskeletal and Skin Diseases....

Weill Cornell Research Reveals Secrets Of Trafficking Within Cells

...nell Medical College. "It's well known in obesity, for example, that even a tiny change in metabolic rate...Dr. Ryan said the findings have broad implications for cells throughout the body, including those closely tied to brain disorders, cardiac illness, and oth...

Experiments provide proof of how traveling in groups protects insects

...y such groups of insects form has mystified humans for thousands of years. One firmly held belief was that God was punishing men and women for their sins. A more recent, scientific theory has been the "safety-in-numbers" idea -- that the small...

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