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Jefferson Virologists Coax HIV Out of Hiding

... mettle, the work could lead to improvedtreatments for HIV infection, and might be a step toward complete.... Pomerantz, who is director of Jefferson’s Center for Human Virologyand Biodefense, and his co-workers took blood cells from HIV-infectedpatients who had ...

Novel Therapy Tested in Mice Could Chase Away Cat Allergies

...ising results could lead to a new therapy not only for human cat allergies, but also possibly for severe food allergies such as those to peanuts. The National Institute of Allergy and Infectious Di...

Sea skate experiment sheds light on human cell transport

...itorial. Goldstein said the results are important for a few reasons. Because skate red blood cells clos...coupled with phosphorylation, is a broad mechanism for getting substances in and out of cells," Goldstein said. "The idea that we can apply this knowledge ...

Color-blind method opens new doors in DNA sequencing

...ensity of fluorescent signal, eliminating the need for further software processing to yield readable sequ...encing, by its very nature, is a process that begs for precision, and the number of mistakes that can be tolerated is extremely low," said Curl, University...

Clam embryo study shows pollutant mixture adversely affects nerve cell development

.... The species is famousamong scientists as a model for the study of cellular processes thatare common among all animals, including humans.Reinisch and her colleagues collected surf clam eggs and sperm,fertilized them in vitro, and added BCE to normally developing clamembryos. The investigators used a com...

Female sex hormones play a vital role in defense against sexually transmitted diseases

...al against HSV-2 and if the mice results hold true for women, they could suggest vaccination protocols un... every four sexually active adults is seropositive for HSV-2 and women are much more susceptible than men. "The results directly indicate that the hormona...

Yale Scientists Find MicroRNA Regulates Ras Cancer Gene

...lated in lung cancer, presenting new possibilities for diagnosis and treatment. The work is reported in M...7 microRNA regulates Ras by binding to the message for Ras and likely inhibits translation of the Ras protein," said Slack. "The microRNA does not revert a...

Study identifies predictors of HIV drug resistance in patients beginning triple therapy

.... The species is famousamong scientists as a model for the study of cellular processes thatare common among all animals, including humans.Reinisch and her colleagues collected surf clam eggs and sperm,fertilized them in vitro, and added BCE to normally developing clamembryos. The investigators used a com...

An HIV Protein Plays a Surprising Role in Gene Activation

...n activator encoded in the HIV genome, is required for HIV gene activation and viral replication. It affe...vator called E1a—the authors show that what's true for yeast also holds for mammals, or at least for the human cell lines investigated here. Each effector ...

Mouse brain tumors mimic those in human genetic disorder

...ith the disease, have oneabnormal copy of the gene for NF1 in every cell in their body, whilespecific sup...hat are produced early in life, which are critical for tumorformation and expansion," Gutmann explains.Optic pathway gliomas in humans are typically surrou...

Automatic extraction of gene/protein biological functions from biomedical text

...c functional annotations of genes are quite useful for interpreting large amounts of high-throughput data efficiently, the demand for automatic extraction of information related to gene functions from text has been increasing. Result...

New Clues Add 40,000 Years to Age of Human Species

...are part of the geological record scientists study for indications of climate change. The team believes t... to the Lake Turkana region in 1967, they searched for the earliest remains of pre-human ancestors. Modern humans were not a priority at the time, and whe...

Enzyme allows B cells to resist death, leading to leukemia

...s enzyme therefore represents an attractive target for therapy.The study will appear online on January 13 in advance of publication inthe February 1 print edition of the Journal of Clinical Investigation....

A bacterial genome reveals new targets to combat infectious disease

More than a billion people are at risk for infection with filarial nematodes, parasites that ...this relationship may help identify new strategies for controlling diseases caused by filarial nematodes. In a new study published in the freely-available ...

Spider Venom Could Yield Eco-Friendly Insecticides

Biochemist Glenn King is searching for an alternative to chemical pesticides. King's rese... humans and insects -- is an ideal source of venom for King's research. The spider "cooperates" by rearing up in a fighting stance when provoked, making it...

New imaging method gives early indication if brain cancer therapy is effective, U-M study shows

...e in diffusion, which Ross said could be accounted for by the swelling some cells undergo before dying; a...diffusion," Ross said. The researchers found that for each of the 20 patients, a change in the diffusion MRI accurately predicted the tumor's response. Re...

Gene variations explain drug dose required to control seizures

...gs by researchers at the Duke University Institute for Genome Sciences & Policy (IGSP) and the Univer...o find the dose of anti-epilepsy drugs appropriate for them. The researchers found that variants of two genes were more likely to be found in patients who...

Solution to Pollution: New Bacteria Eats Toxic Waste

...scovered a new bacteria that is a natural cleanser for contaminated soil. The bacteria, now being used ar...icrobes. The three Libby-site microbes responsible for the remediation were mycobacterium isolates. The other two mycobacterium isolates capable of degradi...

Scientists collaborate to assess health of global environment

...l benefits that human societies depend on and take for granted--basic necessities such as food, clean air...ington, D.C., which will focus on the implications for the United States and international business institutions. Funded by the Global Environment Facilit...

Muscle-targeted gene therapy reverses rare muscular dystrophy in mice

... Using genetically altered mice in which the gene for the enzyme had been rendered nonfunctional, the re...be considered as a potential gene therapy strategy for Pompe disease patients, the researchers report in a forthcoming issue of Molecular Therapy (now avai...

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