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Scientists find missing enzyme for tuberculosis iron scavenging pathway

...y a "missing enzyme" from the biosynthetic pathway for an agent used by the bacteria to scavenge iron. T...urnal of Biological Chemistry, an American Society for Biochemistry and Molecular Biology journal. Mycobacterium tuberculosis, the causative agent of tube...

Improved Outcomes Releases GeneLinker(TM) Gold and Platinum Version 4.6

...d analyzingprotein biomarker data, a high priority for many of our customers. Forexample, we have integra...entific Officer of IOS. "The feature set required for microarray analysis is becoming moremature so we have been concentrating more on proteomics data rec...

Novel Enzyme Shows Potential As An Anti-HIV Target

...ion factor Tat (“transactivator of transcription?, for example, is an essential regulator of HIV gene exp...ols transcription by recruiting cofactors required for transcription. Acetylation and deacetylation enzymes can also target other proteins. Of the three c...

Scientists seek answers on what activates deadly anthrax spores

...." Claiborne, co-director of Wake Forest's Center for Structural Biology, added, "Basic understanding of...at block the process." The research is being paid for by a $152,687 grant from the Southeast Regional Center of Excellence in Biodefense and Emerging Infe...

Found: Missing sequence of the human Y chromosome

...e paper ?tested 100 men of different ethnic origin for the presenceof this 554-kilobase fragment. Indeed,... effort tocharacterize the molecular genetic basis for Y-chromosome-linkedphenotypes. Rappold and colleagues had previously physically mapped theGCY locus,...

U of M researcher examines newly emerging deadly disease

...perts have identified three recommended treatments for purpura fulminans. Patients who present symptoms of purpura should receive antibiotic therapy not only against Neisseria meningitidis and streptococci, but also against methicillin-resistant S. aureus (MRSA), with the consideration that the staphyloc...

NYU Study Reveals How Brain's Immune System Fights Viral Encephalitis

...Recently, the West Nile virus has been responsible for a viral encephalitis outbreak in the northeast. The NYU researchers set out to determine how the body can fight viral encephalitis. Specifically, they examined how type I interferons--proteins made by the body that are released in response to stimuli...

Study finds more than one-third of human genome regulated by RNA

...n thetwo. But researchers from Whitehead Institute for Biomedical Researchand Massachusetts Institute of ...t are common to these five species, the teamlooked for correspondence between the microRNAs and the protein-codinggenes. They discovered that regulation of...

Live Recombinant Adenovirus Vaccine Technique Explored

... Health are exploring ways to develop new vaccines for a variety of illnesses using genetically modified ...d effective. The researchers believe their process for constructing a replicating live recombinant adenovirus could lead to more economical vaccines that p...

Marburg virus disease in Angola - update

...ases have been laboratory confirmed by the Centers for Disease Control and Prevention (CDC), Atlanta, USA...including experts from the Inter-country programme for southern Africa, the Regional Office for Africa (AFRO) and from Headquarters, and partners in the Gl...

Emory Eye Center Implants Its First Retinal Chips In Patients With Retinitis Pigmentosa

...al degeneration in both eyes. It is a general term for a number of diseases that predominantly affect the...on five patients. Another two patients are planned for mid-February. "This experimental device may make it possible for those with retinitis pigmentosa to...

The secret lives of whales

...e meat market, where Antarctic minke whales killed for “scientific research?are legally sold as food, Pal...the recovery of other whales, pointing to the need for resumed whaling. Yet the whales?varied DNA reveals a different story, a past with an ocean teeming w...

NYU researchers simulate molecular biological clock

...n thetwo. But researchers from Whitehead Institute for Biomedical Researchand Massachusetts Institute of ...t are common to these five species, the teamlooked for correspondence between the microRNAs and the protein-codinggenes. They discovered that regulation of...

Dinosaur DNA? New Patent Covers Degraded DNA recovery

...d CEO of DermaPlus, Inc. The patent covers methods for recovering and reconstituting genes from "degraded...nt #5,593,883 was granted to Ambergene Corporation for the recovery of live ancient bacteria and fungi fossilized in amber. By reconstituting nucleic acid...

Leukemia Drug Breakthrough Study In New England Journal Of Medicine

...y developed the phase I clinical trial of Revlimid for treatment of MDS following his laboratory observat...rug Administration in a new drug application (NDA) for Revlimid as an innovative approach to treat the anemia of MDS patients with the 5q minus deletion. ...

Mitochondrial DNA mutations play significant role in prostate cancer

...nd Douglas C. Wallace, PhD, director of the Center for Molecular andMitochondrial Medicine and Genetics a...cell growth, the researchersthen tested the tumors for oxygen radical production. The tumors withthe mutant mtDNAs generated significantly more oxygen radi...

Gene therapy converts dead bone graft to new, living tissue

... splint as living bone, is a promising development for the thousands of cancer and trauma patients each y..., then scanned the surrounding inflammatory tissue for differences in the levels of the active genes. He discovered that the genes that create two key prot...

Antibiotic Resistant Bacterium Uses Sonar-like Strategy to “See?Enemies or Prey

...rmal body cells or other bacteria) and target them for destruction.Reported in the December 24 issue of S...ese bacteriaare actively probing their environment for enemies or food. Based onwhether or not they ‘see?other cells, they make the toxinappropriately.?Gil...

Researchers reveal the infectious impact of salmon farms on wild salmon

...t levels near the farm and exceeded ambient levels for 30 kilometers of the wild migration route." This ...ase in sea lice abundance is likely to be damaging for already dwindling wild salmon populations in British Columbia, where the study took place. In Europ...

Molecular machine may lead to new drugs to combat human diseases

...e genetic material is revealing possible new paths for treating diseases such as some forms of cancer and...emoval from RNA, which translates DNA's directions for gene behavior. Introns then splice the RNA back together. Scientists are just learning whether many ...

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