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Tag: "folds" at biology news

Scientists develop new color-coded test for protein folding

...a protein molecule attached to a gold nanoparticle folds or unfolds. The new technique, which works on the same principle as ordinary pH tests that measure the acidity of water, is described in the March 2005 issue of the journal Chemistry and Biology. "What we've developed is a simple and inexpensive sen...

Institute for Systems Biology Symposium Addresses Need for Better Computational Tools

.../3 of the predicted structures will match previous folds now stored in the protein data bank/PDB. Folded proteins explain many biological functions -- just as the parts in a car determine the role they play in the car's function, three dimensional protein structures of protein determine the roles they pla...

Study shows how retinoic acid enters a cell's nucleus

... now researchers have something new to look for -- folds in a molecule's structure and amino acids that flip when exposed to a hormone or a drug. Noy currently is working with an ILBP that she has pinpointed as a pro-carcinogen -- it promotes cancer. Armed with new tools and knowledge, she hopes to figure ...

Beyond genes: Lipid helps cell wall protein fold into proper shape

...netically determined sequence that dictates how it folds so that it can function properly. Its lipid environment also plays a role," Dowhan said. "People used to assume that specific lipids made no difference." In the JBC paper, Dowhan and colleagues looked at how a protein called GabP, which transports a...

Hopkins scientists uncover 'tags' that force proteins to cell surface

...ms unlikely to disrupt how the rest of the protein folds in a three-dimensional structure, but that's what most scientists think goes wrong if a protein doesn't go to the surface," says Li. "But now we know the problem might just be a faulty transportation signal." Given that proteins can be thousands of ...

Mining biotech's data mother lode

... novel. When a gene encodes a protein, the protein folds up into a unique shape, forming a 3D structure. This structure can only interact, or fit, with some proteins, but not others, like pieces of a jigsaw puzzle. BioGrid's protein interaction software includes a database of the 20,000 known protein stru...

Many needles, many haystacks

...ts of a sticky string of amino acids which usually folds up because of attractions between some of its atoms. This creates a bundle called a globular domain whose shape and chemistry determine what other molecules can bind to it. "If we could look at the chemical 'spelling' of a protein and guess what mac...

Gut protein found to protect against infection and intestinal breakdown

... found that FXR molecules heavily lined the inside folds of the intestine in adult mice. "It's perfectly positioned," Dr. Kliewer said. "It's expressed in just the right place to protect us from the environment." When the bile ducts of mice were tied off, preventing bile from reaching the intestine, addi...

New vaccine for condition that kills 500,000 children a year

...tients. Intussusception takes place when the bowel folds in on itself, causing an intestinal blockage. Because the bowel obstruction was so rare, and the increased incidence was so small, the only way to evaluate the safety of a new rotavirus vaccine was to launch a clinical trial involving more than 60,0...

Protein folding: Building a strong foundation

...e protein azurin, a copper-containing protein that folds into a sandwich-like structure called a beta sheet, which is a common fold in nature that consists of two beta-sheets of amino-acid strands meshed together. "In folding study the right combination of expertise in computational and experimental appr...

RNA enzyme structure offers a glimpse into the origins of life

...ne stem, and the structure shows that the molecule folds in such a way that parts of another stem are positioned over the ligation site, forming a pocket where the reaction takes place. A magnesium ion bound to one stem and positioned in the pocket plays an important role in the reaction, Robertson said. ...

MIT model helps researchers 'see' brain development

...Understanding the functional significance of these folds is one of the big open questions in neuroscience. ...such studies by helping researchers “see?how those folds develop and decay in the cerebral cortex. By applying computer graphics techniques to brain image...

Study of protein folds offers insight into metabolic evolution

...of their component structures: easily recognizable folds in the proteins that have known enzymatic activiti... assumption: that the most widely utilized protein folds (they looked at proteins in more than 200 species) were also the most ancient. "Protein architect...

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