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Tag: "folding" at biology news

Bacteria that cause tooth decay able to survive without important biochemical pathway

...eved a certain biochemical pathway involved in the folding and delivery of proteins to cell membranes is essential for survival. Now University of Florida researchers have discovered that Streptococcus mutans, the decay-causing organism that thrives in many a mouth, can do just fine without it. The findings...

Discovering the first steps in transcription-coupled repair

...uch as a highly repetitive sequence of bases, with folding of the DNA upon itself, which make progress difficult. Unable to continue copying, RNAPII pauses and sometimes grinds to a halt. Exposure to sunlight causes decreased transcription when ultraviolet-induced DNA damage blocks RNAPII. Transcription-cou...

Free-energy theory borne out in large-scale protein folding

...ined computer modeling and experimental results in folding studies for small proteins, but this is the first ... really matters, and our interest is in creating a folding roadmap of sorts, a plot of the thermodynamic route that the protein follows as it moves toward equi...

NYU chemists use computer simulation to enhance understanding of DNA transcription

...old into a condensed fiber as salt increases. This folding and the interplay between chromatin structures reg... DNAs in the array were repelled, preventing array folding and resulting in a bead-like structure. However, under high-salt conditions, screening of linker DNA...

Beyond genes: Lipid helps cell wall protein fold into proper shape

...rrier of cell membranes, play a direct role in the folding of membrane proteins ?proteins that penetrate the ...rstanding the molecular basis for membrane protein folding will help researchers address serious diseases caused by misfolded proteins. "In cystic fibrosis, Al...

Study shows how retinoic acid enters a cell's nucleus

...f efforts in structural genomics, the study of the folding motifs in proteins, which allows researchers to compare 3-D structures of seemingly unrelated proteins. "Advances in structural genomics will allow you to predict what the protein does," Noy says. ...

Health costs soar as 60 million Americans classed as obese

...apes, the researchers are using DNA to control the folding and resulting structure of RNA. Eventually, they e...hen the researchers add magnesium ions to initiate folding of the RNA. "Folding of the RNA structure competes with formation of the DNA constraint until a che...

UN successfully tests 'green' pesticide against locusts

...apes, the researchers are using DNA to control the folding and resulting structure of RNA. Eventually, they e...hen the researchers add magnesium ions to initiate folding of the RNA. "Folding of the RNA structure competes with formation of the DNA constraint until a che...

DNA constraints control structure of attached macromolecules

...apes, the researchers are using DNA to control the folding and resulting structure of RNA. Eventually, they e...hen the researchers add magnesium ions to initiate folding of the RNA. "Folding of the RNA structure competes with formation of the DNA constraint until a che...

Conserved amino acids play both structural and mechanistic roles in sandwich-like protein

...st confirm that. "Better understanding of protein folding is crucial for curing human diseases directly related to misfolding of proteins, and it is also important for the design and improvement of therapeutic enzymes," Wittung-Stafshede said. ...

Biochemists report discovery of structure of major piece of telomerase; implications for cancer

... structure, we now understand how they disrupt the folding and stability of the RNA and why they are disease mutations." For telomerase to be active, it needs the telomerase RNA and a protein called human telomerase reverse transcriptase, which is related to the reverse transcriptase protein that is importa...

Multi-purpose protein regulates new protein synthesis and immune cell development

...ER membrane, or when something goes wrong with the folding process, the entire system can get clogged with un... of more chaperone proteins to assist with protein folding and help with protein trafficking. And third, it activates genes involved in protein degradation to ...

Scientists develop new color-coded test for protein folding

...s have not been previously used to investigate the folding and unfolding of proteins." The initial batch of gold-cytochrome solution had a rosy red hue and a pH value of 10--about the same as an over-the-counter heartburn medication. But when drops of hydrochloric acid were added, the solution began to chan...

Molecular machine may lead to new drugs to combat human diseases

...eed through their work cycle, they change shape by folding and bending. By crystallizing the complex at various stages, the scientists can determine and study its three-dimensional structure and learn how it is able to carry out its biochemical work. The Group I intron at its work cycle's mid-point, which G...

Researchers find how protein allows insects to detect and respond to pheromones

...new drugs andtreatments.Rosetta works by virtually folding protein sequences into thousands ofpossible shapes, based on certain protein folding "rules" known byscientists. These rules are summarized in the program and are termedthe "Rosetta sco...

UW's Rosetta software to unlock secrets of many human proteins

...new drugs andtreatments.Rosetta works by virtually folding protein sequences into thousands ofpossible shapes, based on certain protein folding "rules" known byscientists. These rules are summarized in the program and are termedthe "Rosetta sco...

UAB scientists discover the origin of a mysterious physical force

...In these cases, accurately identifying the protein folding is essential, since the form these proteins take on when they fold influences how effectively they are able to act. Fully understanding the properties of this force that occurs when molecules surrounded by water adhere to each other is also useful i...

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