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Tag: "fold" at biology news

Promiscuous Catalytic Activity Possessed by Novel Enzyme Structure

...spacious barrel-like structure, unlike any protein fold ever seen before. Not only does this wide barrel allow Orf2 to act on such a wide range of aromatic molecules, its discovery could also shed new light on the relationship between an enzyme’s structure, the way it has evolved, and the chemical reactio...

First production of human monoclonal antibodies in chicken eggs published in Nature Biotechnology

...bodies produced in this manner demonstrated 10-100 fold greater cell-killing ability (ADCC) compared to therapeutic antibodies produced by conventional cell culture methods. The new report was published in the September issue of Nature Biotechnology by researchers from Origen Therapeutics and their colla...

Brown-Harvard team solves mobile DNA's surgical sleight-of-hand

...er" proteins ?think of them as nurses ?intricately fold the DNA strands during this surgery. Marta Radman-Livaja, a postdoctoral research associate at Brown, conducted the biological and biochemical aspects of the experiments. The Harvard team ?Tapan Biswas, Hideki Aihara, David Filman and Tom Ellenberge...

Conserved amino acids play both structural and mechanistic roles in sandwich-like protein

...ansfer. Azurin is part of a group of proteins that fold into a sandwich-like structure consisting of two sheets of amino acids meshed together. Nearly 70 superfamilies of proteins of varying makeup have this sandwich-like structure, but they all have eight particular amino acids in common. Previous studie...

Biochemists report discovery of structure of major piece of telomerase; implications for cancer

...c effect on the stability of the three-dimensional fold of the RNA, which is essential for the function of the enzyme, and causes aplastic anemia in patients who have this mutation. "There are five known disease mutations in this part of the RNA identified so far. For three of them, it was not clear why ...

Multi-purpose protein regulates new protein synthesis and immune cell development

... coded instructions from genes. Chaperone proteins fold these amino acid chains into specific shapes and direct them to different areas of the ER for processing. When too many amino acids pile up in the ER membrane, or when something goes wrong with the folding process, the entire system can get clogged ...

Researchers find how protein allows insects to detect and respond to pheromones

...man proteins with no known function. "Howproteins fold determines how they are structured," said Lars Malmstroemof the UW laboratory that developed the program, "And how they arestructured is related to their function in the body."Because there is an astronomical number of possible conformations for agiv...

UW's Rosetta software to unlock secrets of many human proteins

...man proteins with no known function. "Howproteins fold determines how they are structured," said Lars Malmstroemof the UW laboratory that developed the program, "And how they arestructured is related to their function in the body."Because there is an astronomical number of possible conformations for agiv...

Anti-bacterial additive widespread in U.S. waterways

...ts-per-billion). This maximum concentration was 28 fold higher thanpreviously reported levels, which are currently used by the U.S.Environmental Protection Agency for evaluation of the ecological andhuman health risks of triclocarban."Along with its chemical cousin triclosan, the antimicrobial compoundtri...

UAB scientists discover the origin of a mysterious physical force

...l, since the form these proteins take on when they fold influences how effectively they are able to act. Fully understanding the properties of this force that occurs when molecules surrounded by water adhere to each other is also useful in the chemical industry, particularly when involving mechanisms in ...

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