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Tag: "fold" at biology news

Super-sized cassava plants may help fight hunger in Africa

.... The roots of the modified plants were up to 2.6 fold larger than the roots of a non-modified plant (an average of 198 grams for the biggest roots vs. 74 grams for the roots of the non-modified plant.) The modified plants produced a maximum of 12 roots, compared to the seven roots produced by the non-mo...

History of human cannibalism eats away at researchers

...ene ( PRNP ) encodes a protein that can abnormally fold and amass in brain tissues to cause fatal neurodegenerative diseases such as mad cow disease. These diseases are cumulatively known as transmissible spongiform encephalopathies (TSEs) and in humans, include CJD (Creutzfeldt-Jakob disease) and kuru....

Scientists identify molecular structure of key viral protein

...ing a scientific trick on the protein to get it to fold properly and keep it in its metastable state. Because the molecules of the protein are so small they could not be imaged directly. Instead, the researchers used many of these molecules to create a crystal that could be imaged. Using the method of X...

UW-Madison engineers squeeze secrets from proteins

...a delicate balance between the energy available to fold the protein and entropy, or it's desire to be in the unfolded state." De Pablo's research team developed a method to precisely calculate the entropy and determine how much of a protein's stability change upon confinement to attribute to energy and h...

Free-energy theory borne out in large-scale protein folding

... know proteins containing 100 or fewer amino acids fold in a very cooperative (all-or-none) fashion, it is believed that larger proteins fold through the formation of partially folded intermediate structures before settling into their final s...

Field tested: Grasslands won't help buffer climate change as carbon dioxide levels rise

...using X-ray crystallography. How microcompartments fold into their functional shapes remains a mystery. Yeates' laboratory will continue to study the structures of microcompartments from other organisms. If microcompartments can be engineered, biotechnology applications potentially could arise from this...

Nighttime Dying Linked To Sleep Apnea From Brain Cell Loss

...using X-ray crystallography. How microcompartments fold into their functional shapes remains a mystery. Yeates' laboratory will continue to study the structures of microcompartments from other organisms. If microcompartments can be engineered, biotechnology applications potentially could arise from this...

New discovery blurs distinction between human cells and those of bacteria

...using X-ray crystallography. How microcompartments fold into their functional shapes remains a mystery. Yeates' laboratory will continue to study the structures of microcompartments from other organisms. If microcompartments can be engineered, biotechnology applications potentially could arise from this...

Einstein researchers identify new way that bacteria develop resistance to antibiotics

... the researchers found that the protein contains a fold that mimics DNA. So rather than binding with DNA--and becoming a target for the fluoroquinolones--DNA gyrase instead binds with the DNA "mimic" MfpA, rendering the fluoroquinolones ineffective. Proteins similar to MfpA are also present in Shigella, E...

Stressed cells spark DNA repair missteps and speed evolution

...essed cells, and that the rate of errors was 6,000 fold higher than in cells whose DNA was not broken. "It's really about local repair," said Rosenberg. Not only that, but subsequent experiments proved that this mechanism of increased mutation at sites of DNA repair occurs only in the cells under stress....

Computers close in on protein structure prediction

...." It takes less than one minute for a protein to fold into its correct shape in cells, but one oft-repeated estimate predicts it would take longer than the age of the universe for a computer to sample all the possible confirmations of a folded protein. Baker's lab already receives help from supercomputi...

UCSD discovery may provide novel method to generate medically useful proteins

...nging because the loops would have the tendency to fold incorrectly. "Because of its stability, the phage protein makes a better model to create protein diversity in a test tube," explained Jason Miller, a graduate student in Ghosh's lab who conducted much of the research. "Our discovery shows that na...

NYU chemists use computer simulation to enhance understanding of DNA transcription

...tin that appear as bead-like structures along DNA, fold into a condensed fiber as salt increases. This folding and the interplay between chromatin structures regulate fundamental gene expression. However, the molecular mechanism underlying this process remains unclear. The research team, which included N...

‘Blue Brain?project explores thought at molecular level

... genome project in which a draft sequence map of 6 fold genome coverage will be produced. This effort will be coordinated by the international Swine Genome Sequencing Consortium (SGSC) led by scientists from USA and UK. A simultaneous announcement will also be made by SGSC and the Alliance for Animal Geno...

Public release of pig genomic sequences

... genome project in which a draft sequence map of 6 fold genome coverage will be produced. This effort will be coordinated by the international Swine Genome Sequencing Consortium (SGSC) led by scientists from USA and UK. A simultaneous announcement will also be made by SGSC and the Alliance for Animal Geno...

Unweaving amyloid fibers to solve prion puzzles

... prion from the same yeast species could sometimes fold differently, and this fold would form its own cascade of interactions. In this altered form, the prion molecules interact in sl...

Once given 'no respect,' cells' tiny RNAS take driver's seat

...000 building blocks long. Because they are able to fold back on themselves, they form double-stranded RNA, rather than the single strand characteristic of messenger RNA. As a result, the cell breaks the RNA into pieces. All sections except the microRNAs, just 21 to 23 building blocks long, is discarded. ...

Defect in gene causes 'neuralgic amyotrophy'

... such as eyes that are somewhat closer together, a fold in the upper eyelid that covers the inside corner of the eye, and sometimes a cleft palate. HNA is a relatively rare disorder: the disease appears in some 200 families worldwide. There is also a non-hereditary form of HNA, called the Parsonage-Turn...

Beyond genes: Lipid helps cell wall protein fold into proper shape

...ing the E. coli model to discover how all proteins fold in the membrane, not just transport proteins such as GabP but also biosynthetic proteins that manufacture complex compounds such as proteins and fats out of simple compounds. "The next goal now that we've defined the phenomenon is to get into the sp...

Stem cell training program to make its Stanford debut

...spacious barrel-like structure, unlike any protein fold ever seen before. Not only does this wide barrel allow Orf2 to act on such a wide range of aromatic molecules, its discovery could also shed new light on the relationship between an enzyme’s structure, the way it has evolved, and the chemical reactio...

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