Cells direct membrane traffic by channel width
...r membrane channels." For the new study, his team focused on two of them. "Both were from the same bug, E-coli. One was a pure water channel. The other is a glycerol channel," Tajkhorshid said. "Structurally they are similar. Researchers have tried to convert a water channel to a glycerol channel, or the ot...Study: Plants use dual defense system to fight pathogens
...ector molecules into a plant cell, the researchers focused on the actions of two of these molecules ?AvrRpt2 and AvrRpm1. Both target a protein key to Arabidopsis health. The scientists found that both of these effector molecules effectively shut down the PAMP pathway. But the plant's R-proteins detect thi...Genetic variation alters response to common anti-clotting drug
... control variability," explained Rieder. The team focused on another gene: vitamin K epoxide reductase (VKORC1), which makes a protein that helps control clotting and is the key target of warfarin. The researchers analyzed the VKORC1 gene's DNA sequence in 186 patients on a stabilized dose of warfarin. They...Scientists discover genetic pathway responsible for breast cancer cell growth
...ast cancer. In practical terms, efforts can now be focused on developing a more precise cure/treatment for ca...rience side effects," notes Dr. Giguère. "The more focused the drugs the less side effects and the more chance you have to cure the disease." "Research target...Genetic link confirmed between Polynesians and indigenous Taiwanese
...Southeast Asia, Polynesia, and Taiwan. The authors focused specifically on the aboriginal populations of Taiwan, suggested to be ancestors of today's Polynesians, and looked for unique genetic markers that occurred in the aboriginal people. They then compared these markers to those found in mainland Chinese,...Less virulent strains of avian influenza can infect humans
...rus with pandemic potential. Previous studies have focused on the ability of highly pathogenic strains, such as H5N1 "bird flu" circulating in Asia, to spread from poultry to humans. The new study shows less pathogenic strains are also capable of jumping to humans, giving them the opportunity to swap genetic......Southeast Asia, Polynesia, and Taiwan. The authors focused specifically on the aboriginal populations of Taiwan, suggested to be ancestors of today's Polynesians, and looked for unique genetic markers that occurred in the aboriginal people. They then compared these markers to those found in mainland Chinese,...New NIAID grants strengthen national biodefense and emerging infectious diseases research network
...in the region and network * emphasize research focused on development and testing of vaccines, therapeutic and diagnostic concepts * make available core facilities to approved investigators from academia, government, biotech companies and the pharmaceutical industry * provide facilities and scien...Transplanting Animal Organs Could Soon Be A Reality
...rus with pandemic potential. Previous studies have focused on the ability of highly pathogenic strains, such as H5N1 "bird flu" circulating in Asia, to spread from poultry to humans. The new study shows less pathogenic strains are also capable of jumping to humans, giving them the opportunity to swap genetic...Fish and chips: A fast track to understanding blood development
...may regulate stem cells that make blood. They then focused on a group of 61 of these genes that had unknown roles in the function of blood stem cells. Using zebrafish, a small fish that develops red blood cells in a way similar to humans, they "turned off" these genes in the fish embryos and watched to see ...First Whole Genome Map of Genetic Variability in Parkinson’s Disease
...rus with pandemic potential. Previous studies have focused on the ability of highly pathogenic strains, such as H5N1 "bird flu" circulating in Asia, to spread from poultry to humans. The new study shows less pathogenic strains are also capable of jumping to humans, giving them the opportunity to swap genetic...Eating, body weight regulated by specific neurons
...rus with pandemic potential. Previous studies have focused on the ability of highly pathogenic strains, such as H5N1 "bird flu" circulating in Asia, to spread from poultry to humans. The new study shows less pathogenic strains are also capable of jumping to humans, giving them the opportunity to swap genetic......rus with pandemic potential. Previous studies have focused on the ability of highly pathogenic strains, such as H5N1 "bird flu" circulating in Asia, to spread from poultry to humans. The new study shows less pathogenic strains are also capable of jumping to humans, giving them the opportunity to swap genetic...Researchers develop new testing methods for potential monkeypox or smallpox outbreak
...owing the outbreak, the CDC released a report that focused on 11 of the 72 cases. Of those 11, six cases were...ed with the virus. "While this research primarily focused on monkeypox, this same technology could also be used to better detect a smallpox outbreak," said Sl...Prescription pain patch abuse blamed for increase in deaths
...ef of the division of addiction medicine, has been focused on the use and abuse of prescription drugs. In the past few years his team has seen increased abuse of methadone, and now fentanyl. "Based on our study we're recommending that physicians better educate their patients on the use of the patch, and, as...Researchers discover key to human embryonic stem-cell potential
...vid Gifford, and the Harvard lab of Douglas Melton focused on three proteins known to be essential for stem cells. These proteins, Oct4, Sox2, and Nanog, are called "transcription factors," proteins whose job is to regulate gene expression. (Transcription factors are really the genome's primary movers, overs......005, issue of the journal Science. Their analyses focused on detecting sequence changes in two genes - Microcephalin and "abnormal spindle-like microcephaly associated" (ASPM) - across different human populations. In humans, mutations in either of these genes can render the gene nonfunctional and cause micr...Baby's genes affect mom's cholesterol levels
...tion, composed exclusively of water." The study focused on two specific proteins involved in lipid metabolism, lipoprotein lipase and apolipoprotein E. "Apolipoprotein E and lipoprotein lipase play important roles in the degradation of triglyceride-rich lipoproteins," notes Descamps. "In pregnant women, t...An essential regulator of body weight revealed
...e. How does that happen?" While the current study focused on feeding behavior in mice, Palmiter said, "everybody in the field believes that NPY/AgRP neurons and POMC neurons are undoubtedly doing the same thing in humans as they do in rodents. So I would predict that if you could do the experiment in humans...Study hints at role of stem cell genes in testicular, breast cancers
...s OCT 4, NANOG, STELLAR and GDF3. The researchers focused on seminomas ?tumors that account for 50 percent of the cases of testicular cancer, the most frequent cancer in Caucasian males ages 15-40 -- and breast cancers, as represented by a sample of breast cancer cells grown in the culture dish and tissue f...