Molecular mechanism provides intra-cellular traffic signal
...d out of cellular compartments. Activator proteins flip the switches on. One activator protein, called TRAPP, coordinates two Ypt switches for quick entrance and subsequent exit from a central cellular compartment known as the Golgi apparatus. "The Golgi is a central station in all cells, through which ...Changing length of days reverses how estrogen affects aggressiveness in mice
...to less aggressive behaviors, Trainor said. The flip side of this finding is that estrogen increases aggression in short-day mice through different cellular mechanisms not involving genomic pathways. While it would be difficult to test that hypothesis directly, neuroscientists know that when hormone...Losing sleep undoes the rejuvenating effects new learning has on the brain
...a room, something healthy individuals do easily. A flip side is that people with these lesions tend to associate familiar stimuli with new information more rapidly than healthy counterparts, a phenomenon called attention switching. This suggests that learning to ignore stimuli and rapid attention switchi...Carnegie Mellon U. transforms DNA microarrays with standard Internet communications tool
...that begin as one value (0 or 1) may inadvertently flip to the opposite value as they move from one computer to the next in the form of an email. This data loss, ascribed to noise in the communication channel, is checked by counting the number of 1's in the message. If this number is odd, then the last bi...Scientists get first glimpse at how plants, most animals repair UV-damaged DNA
... the portion of the DNA that contains the dimer to flip outwards from the coil and into the pocket. Then, when a photon of visible light hits the pocket, the enzyme becomes excited, and expels one of its own electrons into the dimer, which forces a rearrangement of the atoms in the DNA. "From our work, ...Researchers predict infinite genomes
...ch is to spotlight a species's core genome. On the flip side, scientists may eliminate a core genome, hunting instead for fringe genes that explain a specific strain's unique activity. TIGR researchers say the pan-genome concept also underscores the limits of traditional known genomes. Researchers often ...Study shows how retinoic acid enters a cell's nucleus
... to RA, three amino acids on the CRABP-II molecule flip their positions, exposing positive charges. Combin...lds in a molecule's structure and amino acids that flip when exposed to a hormone or a drug. Noy currently is working with an ILBP that she has pinpointed a...Supercomputers to focus brains on AIDS dilemma
..." said McCammon. This is because the inhibitor can flip to the east if an integrase mutation arises in the west, or to the west if a mutation arises in the east. And because emerging HIV-1 mutations have significantly reduced the usefulness of many previously effective drugs, maintaining the ability to bi...U-M team recovers ancient whale in Egyptian desert
...ing people on ice. Well, we believe we know how to flip the breaker on the patient's furnace; if they have a fever, we believe we know how to stop it on a dime." Roth anticipates that such clinical trials in humans could be under way within about five years. The National Institutes of Health and Fred Hut...Buying Time Through Hibernation on Demand
...ing people on ice. Well, we believe we know how to flip the breaker on the patient's furnace; if they have a fever, we believe we know how to stop it on a dime." Roth anticipates that such clinical trials in humans could be under way within about five years. The National Institutes of Health and Fred Hut...Female sex hormones play a vital role in defense against sexually transmitted diseases
...trategies," said Kaushic. "There is of course the flip side to this as well. Our studies in mice and in fact a number of clinical studies as well show that women who use Depo-provera, a progesterone based injectable contraceptive, have particularly high susceptibility to sexually transmitted infections, ...Columbia research lifts major hurdle to gene therapy for cancer
...abundantinside cancer cells. Both of the molecules flip a switch (called PEG)that turns on the production of a cancer-inhibiting protein uniquely intumor cells.The researchers say the PEG switch can be exploited to produce genetherapies that will only kill cancer cells even if the therapy entersnormal cel...