Beyond genes: Lipid helps cell wall protein fold into proper shape
...ity of Texas Medical School at Houston report in a finding that has long-term implications for understanding diseases caused by misfolded proteins such as cystic fibrosis, Alzheimer's disease, and mad cow disease. The paper in today's Journal of Biological Chemistry by Professor of Biochemistry and Molecula...'Shifty-eyed' Monkeys Offer Window Into Brain's Social Reflexes
... look in that same direction.' Platt said that the finding offers the promise of a manipulable animal model of 'social attention' -- how the human brain assesses the goals and intentions of other humans and responds to them. 'It's been long known what parts of the human brain are involved in identifying and ...Researchers identify new catfish family
... rare in that the researchers have had a hard time finding many specimens. They collected just one specimen in a recent five-day expedition. The researchers are concerned about the fish's habitat, which is threatened by exploitation of the forests and possible damming of the rivers it lives in. ...MicroRNA tweaks protein that controls early heart development
...t any expansion of the heart ventricle at all. The finding that this microRNA controls Hand2, and probably several other proteins, is very significant." The UT Southwestern research team is currently screening human patients with congenital heart disease for mutations in the gene miR-1 to determine what hea...Discovery of T-cell 'traffic control' boosts new drug promise
...re quite promising." Progress will also come from finding "uniquely effective combinations of these agents with other immunosuppressive drugs," he says. In animal studies and clinical research with patients over more than a decade, scientists have come to understand that millions of T cells and B cells are...Duke Experiments Boost Radiation's Cancer-Killing Effects
... skilled at circumventing individual therapies and finding new ways to grow. But together, the two therapies more potently inhibited a tumor's ability to sustain and nourish itself by growing new blood vessels around the tumor. Most importantly, the scientists clarified how this master switch, Hypoxia Induc...IBM Transforms the Art of Scientific Expeditions
... skilled at circumventing individual therapies and finding new ways to grow. But together, the two therapies more potently inhibited a tumor's ability to sustain and nourish itself by growing new blood vessels around the tumor. Most importantly, the scientists clarified how this master switch, Hypoxia Induc...Bird samples from Mongolia confirmed as H5N1 avian flu
...y testing of birds that died at Erkhel Lake. Their finding coincided with confirmations of cases of avian influenza in Russia and Kazakhstan. Karesh and Gilbert immediately traveled to the site with a team of Mongolian virologists, veterinarians, and public health officials. Approximately 100 dead birds wer...Study: Predatory dinosaurs had bird-like pulmonary system
... of air sacs similar to that in today's birds. The finding is one of several studies in recent years to paint a new, more avian-like portrait of meat-eaters such as T. rex: The creatures may have had feathers, incubated their eggs, grown quickly and perhaps even breathed like birds. "What was once formally ...Why do aneurysms form? New studies suggest leading role for white blood cells
...hy aneurysms form have begun to take shape. "We're finding that in general, an aneurysm is an inadequate response to injury," Upchurch explains. "Something happens to damage elastin fibers in the blood vessel wall and, for some reason, the immune system's normal healing response doesn't work. Something eats ...One bacteria stops another on contact
...wth of other E. coli bacteria that they touch. The finding was a complete surprise to the scientists, said Low. The discovery may eventually lead to new antimicrobial agents to halt bacterial growth which would be an entirely new system to shut bacteria down, according to the scientists. "This has potentia...Newfound roadblock to interferon effectiveness against malignant melanoma
...rferon resistance of malignant melanoma cells. The finding represents a step forward in understanding the molecular events that govern the growth of this type of cancer and the changes in gene expression and cellular signaling that underlie resistance to established therapies. Malignant melanoma is the dead...UQ researcher tracking key to healing the brain
... in vivo. "Identifying neural stem cells is like finding a needle in a haystack," Dr Rietze said. "The tried and true method is to look for particular markers on the outside of the cell, but this is a long and laborious process. "What we are doing is looking at a distinguishing attribute of stem cells,...Modification of program enables prediction of gene transcription
...CAN has proven to be the best program available at finding both the transcription start site (TSS) and the co...the 5' untranslated region (UTR). All present gene finding systems ?except for N-SCAN ?either ignore the UTR splice sites or incorrectly incorporate them into ...Visceral Leishmaniasis: Successful Vaccine Trial In Dogs
...ffectiveness of such a vaccine in humans. (1) The finding of these proteins furthermore necessitated the development, achieved in 1992, of suitable culture media (patented), with the attached proteins removed. The media normally used ijn fact contain many protein-containing compounds (serumalbumins, albumin...Targeting a key enzyme with gene therapy reversed course of Alzheimer's disease in mouse models
...inger, also at the Salk. "This is a very important finding because humans are usually diagnosed when the disease has already progressed relatively far." But he warns that it is too early to make direct comparisons with the human disease, since mice ordinarily don't develop the symptoms of the disease unless...'Underground' tunnels discovered as means for communication between immune system cells
...stimulating T lymphocytes," added Dr. Salter. The finding that nanotubules play a role in sending molecular signals to other immune system cells calls into question the long-held belief that immune system cells talk to one another solely by secreting substances such as cytokines, the authors say. It now see...Flies on speed offer insight into the roles of dopamine in sleep and arousal
...s to do a similar trick for fruit flies, too. This finding is one of several in a new study that demonstrates a critical role for the neurotransmitter dopamine in the modulation of sleep, wake, and arousal states. The work is reported by Dr. Ralph Greenspan and colleagues at The Neurosciences Institute in S...Neanderthal teeth grew no faster than comparable modern humans'
...mating the length of childhood among hominids, the finding is the latest evidence suggesting that Neanderthals may not have been as different from modern humans as some researchers have thought. The study by Debbie Guatelli-Steinberg, assistant professor of anthropology at Ohio State , appeared in the curr...No small feat: First ever gene therapy success for muscular dystrophy achieved
...iao's lab. Future directions for research include finding a way to engineer the laminin alpha-2 gene. For this study, the authors chose to use the mini-agrin gene because researchers from the University of Basel, Switzerland, had already demonstrated it could improve the symptoms of muscular dystrophy in a ...