Study shows how retinoic acid enters a cell's nucleus
...door for future research on related compounds. The finding has important implications for the fight against cancer and other diseases. The research, which appears in a recent issue of the journal Molecular Cell (Vol. 18, No. 3), explains for the first time how the cancer-fighting vitamin A derivative retino...Pinpointing the cause of a neurodegenerative disorder
...ut the domain's function remained unknown. Then, a finding by co-author Hugo Bellen, an HHMI investigator at ...s outside the glutamine repeat," said Zoghbi. The finding offers insight into the molecular mechanisms that cause SCA1, Huntington's disease and other glutami...OHSU research shows vitamin C counteracts some negative impacts of smoking on unborn babies
...ting smoking during pregnancy. While this research finding may assist the babies of these mothers, it does no...ppeared to be slightly impacted by vitamin C. This finding may be significant as elastin plays a key role in the expansion and contraction of lung during breat...Divergent life history shapes gene expression in brains of salmon
...achusetts and the US Geological Survey, report the finding in the current issue of Proceedings of the Royal S...tly reduced size without leaving freshwater. "The finding that hundreds of the nearly 3,000 genes we studied were expressed differently in the brains of sneak...University of Nevada, Reno research team discovers hormone that causes malaria mosquito to urinate
...oast of the University of London, down the path of finding a way to control insects that are pests at the larval stage, a path that has them instead potentially paving the way for better mosquito control. A potential solution to the problem of killing insects at any stage of development may be found in pept...Scientists focus on 'dwarf eye'
Genetic finding may have implications for farsightedness and nearsightedness, too.Working with an Amish-Mennonite family tree, Johns Hopkins researchers at the Wilmer Eye Institute have discovered what appears to be the first human gene mutation that causes extreme ...Measuring hidden parasites in falciparum malaria
...isease, and was highest in patients who died. This finding fits with current thinking that sequestration of red cells containing the mature forms of the parasite is the most important pathological process in falciparum malaria. Approximately 40% of the world's population, mostly living in the world's poore...Insulin pulses keep the liver lean
...n an accompanying preview. In this case, he added, finding ways to mimic the effects of CEACAM1 might help to alleviate chronically elevated blood and liver lipids in patients with diabetes. Najjar et al.: "Insulin acutely decreases hepatic fatty acid synthase activity." Publishing in Cell Metabolism, Vol. ...Micro-molecule plays big role in birth defects
...the mice grew malformed, nonfunctional limbs. The finding may provide insight into human birth defects, but scientists say its greater value will be as a new technique to study the function and malfunction of microRNAs, more than 200 types of which are thought to exist in the human body. "We looked at limb...Nicotine triggers the same brain reward circuitry as opiates
...e a specific test chamber with receiving nicotine, finding that the mice would prefer to stay in that chamber when given a choice. The researchers found that just placing the conditioned mice in the chamber activated CREB. They also found that naloxone blocked this conditioned increase in CREB, and that muta...New lead reported in tumor angiogenesis
... Michigan and senior author on the paper, said the finding suggests a future anti-angiogenic strategy of blocking not only the secreted molecules but also the cell-to-cell contact. Wang said these early data also suggest the intriguing possibility of directing growth-inhibiting drugs at the normal blood ves...Stem Cells Found In Cerebellum; Possible Cell of Origin for Childhood Brain Tumors
...that are normally found on neural stem cells. This finding perplexed scientists, as stem cells had never been shown to exist in the cerebellum. The Duke study provides the first evidence that stem cells actually exist in the cerebellum and supports the theory that medulloblastomas could arise from these cel...Scientists show that tick-borne flaviviruses use a novel mechanism to evade host defenses
... they are transmitted by mosquitoes or ticks. This finding could lead to new approaches to developing vaccine...laviviruses would use the same protein, so the NS5 finding was unexpected. The RML group, directed by Marshall Bloom, M.D., chose Langat virus because it is s...For first time, brain cells generated in a dish
...man applications, it will enhance efforts aimed at finding ways to use large numbers of a person's own cells to restore damaged brain function, partially because the technique produces cells in far greater amounts than the body can on its own. In addition, the discovery pinpoints the cell that is truly what...Bitter or sweet? The same taste bud can tell the difference
...w that it is also active in taste bud cells. That finding gives scientists a deeper understanding of how the human brain may distinguish between different types of tastes, said Scott Herness, the study's lead author and a professor of oral biology and neuroscience at Ohio State University . The current stu...Virologist finds contagious equine flu in dogs
...ies it must overcome a number of barriers, such as finding a cell receptor to bind to in order to enter the cell and to reproduce sufficiently in the new host. "There are probably many examples of viruses jumping species, but then it becomes a dead-end issue," said Dubovi. Researchers have long known that e...Discovering an ecosystem beneath a collapsed Antarctic ice shelf
...om--it's like lifting the carpet off the floor and finding a layer that you never knew was there." Domack su...an. The recent report, however, presents the first finding of the type in the Antarctic, where the near-freezing water temperatures and almost completely uncha...Malfunctioning bone marrow cells sabotage nerve cells in diabetes
...ceedings of the National Academy of Sciences. The finding not only provides a basis for understanding the dangerous nerve condition in diabetics, but could eventually lead to a treatment for this problem, said Dr. Lawrence Chan, chief of diabetes, endocrinology and metabolism at BCM. It may even provide an ...Cultural norms not unique to human societies
...an and chimpanzee societies." The conformity bias finding was an unexpected, but equally important, result of this culture study, according to Dr. Horner. A few members of each group independently discovered the alternative method for freeing food from the Pan-pipes, but this knowledge did not endanger the ...Monkeypox mystery: New research may explain why 2003 outbreak in the US wasn't deadly
...all over the body, and respiratory problems. "Our finding may explain the lack of case-fatalities in the 2003 monkeypox outbreak in the United States, which was caused by a West African virus," Buller said. ...