Shutting down the HIV assembly line
...in gets there in the first place. The current work fills this gap. Spearman and colleagues used the HIV-1 Gag protein as bait to "fish" for Gag binding partners. They identified several known and novel interacting proteins and selected one, the delta subunit of AP-3, for further evaluation. AP-3 is an "ad...Chemical 'band-aid' prevents heart failure in mice with muscular dystrophy
...unction during the relaxation phase when the heart fills with incoming blood. In our study, we found that cardiac myocytes in dystrophin-deficient mice don't relax and lengthen as readily as cardiac myocytes in normal mice. They are stiffer than normal heart muscle cells, and vulnerable to damage when stre...Techniques available to detect soil that inhibits destructive soybean pest
...k out the nutrients. As the adult female ages, she fills with eggs, turns yellow and then brown to become the nematode cyst. At that point her body is a case to protect hundreds of eggs while they mature, hatch into juveniles and leave the cyst to further attack the plant roots. Swollen females can be seen...New brain hormone puts brakes on reproduction
... the mammalian reproductive system, a hormone that fills a role long suspected, but until now undetected. The hormone, a small protein, or peptide, called gonadotropin-inhibitory hormone (GnIH), puts the brakes on reproduction by directly inhibiting the action of the central hormone of the reproductive sy...Secrets of the sea yield stronger artificial bone
...g the layers lock in place with whatever substance fills the space between them. And some bridges form between the layers, which are believed to increase fracture resistance. "These characteristics contribute to the scaffolding's mechanical toughness. Cracks don't propagate as easily and more energy is ne...Free radical cell death switch identified
...overy of the MST-FOXO biochemical switch mechanism fills a gap in our understanding of how oxidative stress elicits biological responses in neurons, and may include besides cell death, neuronal dysfunction and neuronal recovery. Since oxidative stress in neurons and other cells in the body contribute to t...With record resolution and sensitivity, tool images how life organizes in a cell membrane
...rmation about chemical composition of a sample, it fills a gap left by atomic force microscopy, which provides high-resolution information about topography, but not chemistry, as its microscope tip ''feels'' its way through samples. Plus it handles samples less ordered than those addressed by X-ray crystal...Study of gene transfer for erectile dysfunction shows promise
...pandable tissue along the length of the penis that fills with blood during erection. A variety of clinical and laboratory tests were used to assess safety. In addition, effectiveness was measured using the International Index of Erectile Function scale, a questionnaire that is commonly used to measure ED. ...Hofmeyr skull supports the 'Out of Africa' theory
...â?super>TM s braincase. At this age, the skull fills a significant void in the human fossil record of sub-Saharan Africa from the period between about 70,000 and 15,000 years ago. During this critical period, the archaeological tradition known as the Later Stone Age, with its sophisticated stone and bo......unique position on the tree of life. This analysis fills a crucial gap in our understanding of how mammalian genomes, including our own, have evolved over millions of years," said NHGRI Director Francis S. Collins, M.D., Ph.D. "These new findings illustrate how important it is to understand all of the huma...