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Tag: "fibril" at biology news

Duke Chemists Isolating Individual Molecules Of Toxic Protein In Alzheimer's, Parkinson's Disease

...ientists are also seeking the precise point during fibril formation when interactions between monomers become irreversible. Defining that point is important because "the fibrils are virtually indestructible once formed," he said. "How all these monomers interact to form these amyloid fibrils is just not kn...

Fibril Shape Is The Basis Of Prion Strains And Cross-species Prion Infection

...vered that the particular shape of a prion amyloid fibril was the determining factor in whether one species ...case with the preseeded mice fibrils, a particular fibril shape in Saccharomyces cerevisiae yeast allowed prion transmission to Candida albicans yeast. The tr...

Scripps research study reveals structural dynamics of single prion molecules

...sms as well as those that lead to abnormal amyloid fibril conversion. The new insights may lead to the discovery of novel therapeutic targets for neurodegenerative diseases. Intriguingly, certain prions and amyloids can play beneficial roles. The subject of the new study, Sup35, enables protein-based inher...

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