African parasite makes component of fat differently from all other organisms
...ty acids," says Soo Hee Lee, Ph.D., a postdoctoral fellow in the Department of Biological Chemistry at the Institute for Basic Biomedical Sciences at Hopkins. "It may be that the enzymes in the pathway could be good targets for designing drugs to treat sleeping sickness." The single-celled trypanosome th...Mechanism identified for promising neurological drug
... M. Kauppinen, PhD, currently a neurology research fellow at SFVAMC and UCSF, when she was a graduate student in Finland. Kauppinen found that minocycline, an antibiotic derived from tetracycline, prevents inflammation and apoptosis in cultured brain cells. As a result, "minocycline has received a tremend......netics and the May issue of Evolution, Whitham and fellow researchers discuss how this phenotype is heritable on an ecosystem level. That is, the progeny of a tree are likely to support the same communities of organisms and ecosystem processes that their parents supported. It's a premise with far-reaching...MIT 'seeing machine' offers hope to blind
.... The work is led by Elizabeth Goldring, a senior fellow at MIT's Center for Advanced Visual Studies. She developed the machine over the last 10 years, in collaboration with more than 3O MIT students and some of her personal eye doctors. The new device costs about $4,000, low compared to the $100,000 price...The molecular mechanism of a diabetes vaccine revealed
...ucing pancreatic cells," says Cohen. Postdoctoral fellow Dr. Alexandra Zanin-Zhorov spearheaded the project...e Prof. Ofer Lider, Dr. LioraCahalon, postdoctoral fellow Guy Tal, and Raanan Margalit. ...Magnetism and mimicry of nature hold hope for better medicine, environmental safety
...co. They were aided by ASU postdoctoral research fellow Solitaire Lindsay and graduate students Dongqing Y...d by the Philip Morris USA company. Marquez, and fellow researchers in Spain, including professors Sonia Melle at Universidad Complutense de Madrid and Migu...Septum keeps neurons in synch, can reduce epileptic seizures by 90 percent
... Two promising lines of research Colom and his fellow researchers at the University of Texas at Brownsville/Texas Southmost College are looking at two different approaches to stopping epilepsy. One group is taking the approach of making the neurons less excitable (this effort is led by Emilio Garrido-Sa...Researchers identify human DNA on the fast track
...eloped by Katherine Pollard, a former postdoctoral fellow in Haussler's lab who is now an assistant professor at the University of California, Davis. Pollard compared the DNA sequences of chimps, mice, and rats to find the regions that had remained largely unchanged over the 80 million years or so since the...When the going gets tough, slime molds start synthesizing
.... Noel and Michael Austin, Ph.D., a postdoctoral fellow in Noel's lab and co-lead author of the study, have an ongoing interest in the biosynthesis of diverse plant and microbial polyketides by enzymes known as type III PKSs. Plants make polyketide natural products such as flavonoids and stilbenes for use...Life and death in the hippocampus: what young neurons need to survive
...ues, Gage and a team headed by former postdoctoral fellow Ayumu Tashiro, Ph.D., injected a virus carrying a pair of molecular shears capable of deleting a gene encoding part of the NMDA receptor into the hippocampus, a brain region harboring neural stem cells that give rise to new neurons. Newly born neuron...Heal thyself: Systems biology model reveals how cells avoid becoming cancerous
...while under routine assault." UCSD post-doctoral fellow Christopher T. Workman, Ph.D. candidate Craig Mak, and technicians Scott McCuine and Maya Agarwal analyzed the effect of exposure of yeast cells to MMS (methyl-methanesulfonate), a chemical known to cause DNA damage in a manner similar to that of cer...Experimental RNA-based drug kills prostate cancer cells effectively and safely
...d lead author James McNamara, Ph.D. a postdoctoral fellow in experimental surgery. "It provides a 'proof of principle' that an entirely RNA-based drug can work with minimal side effects, and it shows it is possible to overcome many of the obstacles that have hampered the development of RNA-based drugs." ...Computational analysis shows that plant hormones often go it alone
...ennifer L. Nemhauser, Ph.D., a former postdoctoral fellow in Chory's lab and now assistant professor at the University of Washington in Seattle, and Fangxin Hong, Ph.D., a biostatistician in Chory's lab, found that each of the seven hormones activated largely its own repertoire of target genes. "We found sh...Cells use mix-and-match approach to tailor regulation of genes
...onceptualize," said Andreas Beyer, a post-doctoral fellow at the UCSD Jacobs School of Engineering's Department of Bioengineering. "That's why we have computers." The researchers combined the results of their laboratory with other large-scale measurements of transcription factor-gene binding, such as those...New strategy rapidly identifies cancer targets
... the JAK3 gene. Thomas Mercher, a postdoctoral fellow in Gilliland's lab, then tested the mutation in a mouse model. "It was important to show that the JAK3 mutation, when introduced in mice, would lead to a leukemia-like illness. It did, confirming that the JAK3 mutations play a central role in l...Today's babies are fatter babies
...med this research at DACP while she was a research fellow in the Public Health Nutrition Program at the Harvard School of Public Health. Gillman and colleagues collected data from well-child visits among more than 120,000 children younger than 6 years old at 14 Harvard Vanguard Medical Associates practice...New roles for growth factors: Enticing nerve cells to muscles
...or Ryuichi Shirasaki, Ph.D., a former postdoctoral fellow in Pfaff's lab and now a faculty member at Osaka University, Japan; postdoctoral fellow Joseph W. Lewcock, Ph.D.; and research assistant Karen Lettieri, both at Salk. ...Salk and Stanford teams join forces to reveal two paths of neurodegeneration
...and co-lead author Todd McLaughlin, a postdoctoral fellow in the O'Leary lab. When cut, axons in mice or f...ho contributed to this paper included postdoctoral fellow Oren Schuldiner, Ph.D., at Stanford and Ryan Watts, Ph.D., formerly a Ph.D. student in Luo's lab and...New study reveals signaling pathways required for expansion of pancreas stem cells
...f pancreatic progenitors. Hong Hua, a postdoctoral fellow in Sarvetnick's lab, was the lead author of this study. The progression of pancreatic stem cells to beta cells is governed by the expression of key proteins, including a class of proteins called bHLH transcription factors that regulate gene expressi...... said Dr. Andrew Iwaniuk, a post-doctoral research fellow in the U of A's Department of Psychology. "It has been years since it has been used and still has this effect." The new research, published in Behavioural Brain Research, strongly suggests that exposure to environmental levels of DDT causes signifi...