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Tag: "feedback" at biology news

Unique dual target specificity of kinase inhibitor key for success against cancer

... be concurrently inhibited because of a regulatory feedback loop that renders a monospecific inhibitor ineffective. Importantly, dual inhibition of p110á and mTOR with a low dose of PI-103 elicited no drug-related toxicity and was highly effective against human gliomas transplanted into mice. "These data su...

Brain's 'gambling circuitry' identified

...proaches, and may also gauge the impact on and the feedback from higher-level brain regions known to contribute to decision making." ...

No-mow grass may be coming to your yard soon

...atively regulate their own expression as part of a feedback loop that, ultimately, determines the size of a plant. In nature, that feedback loop has served plants well, helping them adjust their height and size to fit the growing conditions...

Plants' role in global warming re-examined

... response to climate change, and a weaker positive feedback between carbon and climate and a weaker amplification of additional warming," the authors write. The paper concludes by saying, "There is also a need to better understand the control of respiration itself. The development, testing and adoption of a ...

A simple feedback resistor switch keeps latent HIV from awakening

...cluding HIV, regulate their potential for positive feedback and maintain latency by successively modifying and dissipating, or introducing a resistor into, the main activator of transcription. HIV's transcriptional activator, the Tat gene, is encoded in the HIV genome. Once Tat is transcribed, it can rapid...

A human taste for rarity spells disaster for endangered species

...s. Prizing rarity, they found, triggers a positive feedback loop between exploitation and rarity that drives a species into an extinction vortex. This phenomenon, the authors explain, resembles an ecological process called the Allee effect, in which individuals of many plant and animal species suffer reduce...

Prototype just-in-time medical device enables untrained bystanders to save lives

...es to tell the user what to do and give him or her feedback about actions taken. The cues were based on American Heart Association protocols. Half the 40 participants used the JITS device and half did not. Those using the device not only surpassed the no-device group in every measure but performed to the le...

Altered perception of reward in human cocaine addiction

...drug-addicted individuals to use internal cues and feedback from the environment to inhibit inappropriate behavior, and may also predispose these individuals to disadvantageous decisions -- for example, trading a car for a couple of cocaine hits. Without a relative context, drug use and its intense effects --...

New tool helps blood specialists improve patient care

... with MDS. The data collected and analyzed provide feedback on specific ways in which their patient care could be improved, and are used as a basis for designing and implementing a practice improvement plan. The Self-Directed PIM makes it easy to enter the data, design the improvement plan, and report to ABIM...

Siberian lakes burp 'time-bomb' greenhouse gas

...han previously estimated" and acting as a positive feedback to climate warming, said Katey Walter, in a paper published today in the journal Nature. Walter's project is the first time this type of bubbling has been accurately quantified. "We realized that our previous estimates were missing a very large and ...

Sensory feedback during speech: The brain attunes to more than just sound

...ly produce words is dependent not only on auditory feedback signals to the brain, but also on so-called somato...terference, thereby "correcting" the somatosensory feedback the brain receives during speech. This learning took place even when speech sounded normal, and it o...

Train your brain to hear your friends at a party

...ontract the pupil and let in less light. This is a feedback system where the brain is getting information from...e the place in the brain which is channeling these feedback messages back to the ear. "We already have a likely candidate called the OCB, the Olivocochlear B...

Decoy pill saves brain cells

...odegenerative in such a way as to start a positive feedback loop that leads to ever-higher levels of calcium a...ction to continue. In addition, it interrupted the feedback loop that stoked calpain activation. "This is potentially a treatment for any conditions that inv...

Reminding doctors which antibiotics to prescribe cuts C. difficile infection rates

...ctors which antibiotics to prescribe combined with feedback on antibiotics use and CDI rates led to a signific...London, and colleagues investigated whether use of feedback to individual doctors about their prescribing habits can improve adherence to a narrow-spectrum anti...

Conceptualizing a cyborg

... stimuli, such as temperature or pressure provides feedback to adapt the movements. The central feature of the proposed interface is the ability to create transplantable living nervous tissue already coupled to electrodes. Like an extension cord, of sorts, the non-electrode end of the lab-grown nervous t...

Mimicking how the brain recognizes street scenes

...s now elaborating the model to include the brain's feedback loops from the cognitive centers. This slower form of object recognition provides time for context and reflection, such as: if I see a car, it must be on the road not in the sky. Giving the model the ability to recognize such semantic features will e...

Scientists uncover link between ocean's chemical processes and microscopic floating plants

...efforts will lead to a better understanding of the feedback systems between the atmosphere and ocean, believes Wingenter. "To predict future climate more accurately, it's critical that we understand the outcome of increasing ocean acidification and increasing carbon dioxide levels." ...

Executable biology -- Computer science sheds light on animal development

...cellular signaling pathways, as well as a negative feedback loop that had not been described before. These kinds of models hold great promise for future exploration of a variety of biological systems, explains lead EPFL researcher and biologist Dr. Jasmin Fisher. "Once a robust model has been built of a p...

Latent memory of cells comes to life

...By building a mathematical model based on positive feedback from the microscopic state of the nucleosomes, the...hat communication between nucleosomes and positive feedback are likely to constitute fundamental memory mechanisms in individual cells. The mechanism gives both...

Dinosaur hearing, listening to muscle noise, quieter cubicles

...elopment. The system provides quantitative visual feedback that helps students see their vocal performance and produce better results. ...

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