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Tag: "feedback" at biology news

PANTHER Protein Classification System Database 5.0

...rific experience that has provided uswith enormous feedback to improve the process notation and CellDesignersoftware. This is the first time that such a large set of pathwaymodules has been released with such detailed molecular information. Weare pleased to see that the process notation in CellDesigner has pr...

Breast Cancer May Be 'Uniquely Sensitive' To Inhibitors Of PI3K Pathway

...thway and otherpathways, a lot of feed-forward and feedback loops,?says Mills. “But Iand others believe there are central nodes between these intersectingcircles that can be effectively targeted with drugs.?Only one PI3K pathway inhibitor is in use to date, but others areincreasingly being developed and teste...

Genetic Variation Visualization - From EMBL

...thway and otherpathways, a lot of feed-forward and feedback loops,?says Mills. “But Iand others believe there are central nodes between these intersectingcircles that can be effectively targeted with drugs.?Only one PI3K pathway inhibitor is in use to date, but others areincreasingly being developed and teste...

New Mixing Method for Microchip-Sized Labs

...thway and otherpathways, a lot of feed-forward and feedback loops,?says Mills. “But Iand others believe there are central nodes between these intersectingcircles that can be effectively targeted with drugs.?Only one PI3K pathway inhibitor is in use to date, but others areincreasingly being developed and teste...

White blood cell waste disposal system plays critical regulatory role

...cal inhibitory step that is a key component of the feedback circuit regulating the balance between neutrophil production and destruction. The research, published in the March issue of Immunity, suggests that the process for disposal of dying neutrophils is actively linked to neutrophil production. A clear und...

Bird Brains Show How Trial and Error May Contribute to Learning

...otor skills, such as tennis. The process relies on feedback about what works and what doesn't, also called experience-dependent or performance-based learning. "That all requires paying attention to how we're doing, experimenting with different things, and gradually getting better," said senior author Michael...

RNA project to create language for scientists worldwide

...ess at the annual RNA Society meetings and receive feedback from the wider community of researchers. The ontology team will identify all RNA motifs, or repeated patterns, mentioned in the literature or appearing in databases, to agree upon and write a definition for each motif. The consortium's work will be ...

Opposing fat metabolism pathways triggered by a single gene

...spects of fat metabolism, which interact to form a feedback system controlling the consumption and composition of fats in the nematode. Using RNAi to suppress gene expression, the researchers discovered that when nhr-49 was absent, the lifespan of the nematode was reduced by more than 50%, and the animal dis...

Insight into natural cholesterol control suggests novel cholesterol-lowering therapy

...ediate compound in the synthetic pathway--mediates feedback control over the rate of cholesterol production by stimulating the degradation of cholesterol-building reductase. The availability of reductase, which functions early in the synthetic process, largely determines the rate of cellular cholesterol produ...

Brain-mapping technique aids understanding of sleep, wakefulness

... "This creates a self-reinforcing loop, a positive feedback system that's very important to consolidating wakefulness." Dr. Yanagisawa said the trigger that causes the sleep "seesaw" to tip from one side to the other and maintain a proper balance between time spent awake and time spent asleep is still a big ...

White Blood Cell 'Waste Disposal' System Plays Critical Regulatory Role

...cal inhibitory step that is a key component of the feedback circuit regulating the balance between neutrophil production and destruction. The research, published in the March issue of Immunity, suggests that the process for disposal of dying neutrophils is actively linked to neutrophil production. A clear und...

Remote control flies? Fly behavior controlled by laser light

...neural circuit activated by the remote control has feedback loops that keep the circuit. "In the case of the flight circuits," he says, "it is like pushing a swing. One initial kick and it keeps swinging back and forth for a while." ### The study was supported by grants from the National Institutes of Healt...

Random gene expression may drive HIV into hiding

...hen the HIV genome is transcribed and the positive feedback loop kicks in. If these Tat modifications don't happen, then HIV ceases to be expressed, and the cell can then possibly enter a latent state. The significance of fluctuations in expression are dependent on HIV being expressed at a low level in the c...

Morphine for Chest Pain Increases Death Risk

...for patients with non-STEMI and provides quarterly feedback to hospitals with the ultimate goal of improving adherence to the ACC/AHA treatment guidelines and patient outcomes. The CRUSADE registry is funded by Millennium Pharmaceuticals, Cambridge, Mass., and Schering Corp, Kenilworth, N.J. Bristol-Meyers S...

Endocannabinoids ?the brain's cannabis ?demonstrate novel modes of action to stress

...stress response. One explanation for this hormone feedback regulation of the stress response might be to prep...om the pituitary gland, providing a rapid negative feedback mechanism for the regulation of neuroendocrine function during stress." Japanese team finds inhibit...

Lands surface change on Alaska tundra creating longer, warmer summers in Arctic

...oxide to the atmosphere. The result is a positive feedback loop that could continue to raise temperatures in the region and further lengthen the snow-free period each year. Since the early 1960s, scientists have identified "hotspots" of slowly increasing average summer temperatures in the Arctic, from 0.1...

Once given 'no respect,' cells' tiny RNAS take driver's seat

...ppens to be the gene for Myc. "This establishes a feedback loop," says Kathryn O'Donnell, Ph.D., who conducted much of the work as a graduate student in the Human Genetics Program. "Because both Myc and E2F1 increase the expression of genes that increase cell growth, the pair could be quite dangerous if they...

Computer modeling reveals hidden conversations within cells

...one of the chemicals, the proteins create positive feedback that lengthens the amount of time they are active. When exposed to the other chemical, they initiate negative feedback, which shuts them down rapidly. "The prevailing view has been that proteins are either on or off like a light switch, but that di...

Climate change will affect carbon sequestration in oceans, model shows

...nge, ocean circulation, the ocean carbon cycle and feedback mechanisms is crucial for a reliable projection of...tters. "When we ran the model without the climate feedback mechanisms, the Pacific Ocean held more carbon dioxide for a longer time," Cao said. "When we added ...

How 'Dirt' Could Educate The Immune System And Help Treat Asthma

...nge, ocean circulation, the ocean carbon cycle and feedback mechanisms is crucial for a reliable projection of...tters. "When we ran the model without the climate feedback mechanisms, the Pacific Ocean held more carbon dioxide for a longer time," Cao said. "When we added ...

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