UF scientists test improved gene therapy method for hereditary heart conditions
... and long lasting. One of the other distinguishing features of our research is it's probably the first to demonstrate a physiologic correction of a genetic cardiac abnormality." Additional tests in rhesus monkeys conducted in conjunction with scientists at the California National Primate Research Center at ...New potential drug target in tuberculosis
...ds for survival in human cells. This image reveals features of the molecule that could be targeted by new antibiotic drugs. The results appear in this week's online issue of the Proceedings of the National Academy of Sciences (PNAS). M. tuberculosis is dangerous because it hides and persists in the immune ce...Inside rocks, implications for finding life on Mars
...lions of years, and learn what are real biological features and what has been changed over time." His research is published in the January issue of the journal Astrobiology, in which he reports confocal microscopy results of the ancient fossils. (He published ancient Raman spectroscopy 3-D images of ancient ...VCU Massey Cancer Center researchers identify a new class of anti-cancer drugs based on platinum
...effectively kill tumor cells. By understanding the features of cisplatin that contribute to resistance, Farrell and his team designed the new compound to circumvent these problems. ...New 'self-exploding' microcapsules could take sting out of drug delivery
...to do the same job. Each of the new microparticles features a biodegradable gel core that is surrounded by a lipid membrane. As the gel biodegrades, pressure builds up in the membrane. Eventually the microcapsule ruptures, releasing the medication. The system, the researchers note, could change how some vacc......ean, well-aerated water, but without environmental features or enrichment. Earlier work by Nevitt's lab at UC Davis and other labs has shown differences between hatchery-reared and wild fish, Kihslinger said. But most studies have looked at older fish, and have not distinguished between the effects of select...Where 'jumping genes' fear to tread
...ppears that many TFRs are evolutionarily conserved features that existed prior to ?and have been largely maintained since ?the divergence of eutherian mammals and marsupials approximately 170 million years ago." The opossum was chosen for inclusion in the analysis because it is a marsupial that has a similar...Scientists discover new genetic subtypes of common blood cancer
... results in a way that yielded distinctive genomic features from the CGH data. Four distinct myeloma subtypes based on genetic patterns emerged: Two of them corresponded to the non-hyperdiploid and hyperdiploid types, and the latter was found to contain two further subdivisions, called k1 and k2 When these ...Fruit fly reveals a potential connection between dementia and cancer
.... The power of this model, which recapitulates key features of the human disease, lies in the ability to use genetic tools to establish a causal connection between a molecular pathway and neuronal death. Khurana and colleagues found that, as in human disease, abnormal expression of cell-cycle proteins accompa...UF scientists trace origin of shark's electric sense
...onic cells that gives rise to many head and facial features in humans. The discovery, reported by University of Florida scientists in the current edition of Evolution & Development, identifies neural crest cells, which are common in vertebrate development, as a source of sharks' electrical ESP. It also ...Face perception is modulated by sexual orientation
... (facial identity) and variant (facial expression) features are similarly processed in the brain, independent of the gender of the individual who is viewed or the sexual orientation of the viewer. The researchers found that, consistent with their hypothesis, the gender of a viewed individual, when the sexual...Relationship of brain and skull more than just packaging
...ctures located near the top of the brain and boney features at the base of the skull." To look at the correla...oked at the reproducibility of standard anatomical features on the skull and brain. "We found that the brain landmarks people often use were highly variable an...Major WHO study concludes calcium supplements can reduce complications during pregnancy
...rotease enzyme in a brightly colored cartoon, with features that resemble a fat cat face. From the front or the back, the identical halves of the enzyme have an ear and cheek protrusion on each side. (See illustration.) Frayed whiskers even appear to sprout from the bottom. The similarity to a face ends at th...Computer simulation hints at new HIV drug target
...rotease enzyme in a brightly colored cartoon, with features that resemble a fat cat face. From the front or the back, the identical halves of the enzyme have an ear and cheek protrusion on each side. (See illustration.) Frayed whiskers even appear to sprout from the bottom. The similarity to a face ends at th...Molecular mechanism may explain how fevers spark seizures
...s underlying those epilepsies. One of the common features in the families with mutations in the GABA-A receptor gamma subunit -- one of several protein "parts" that come together to make a functional receptor -- is a history of febrile seizures. Kang and Macdonald had already discovered that GABA-A recept...Lizard 'third eye' sheds light on evolution of color vision
...legate each person to do more things." By sharing features found in human photoreceptors as well as those found in simpler organisms like the scallop, the researchers propose that the lizard's parietal eye photoreceptor cells represent a "missing link" between the light-sensing apparatus in lower animals and...Penguins waddle but they don't fall down, UH researchers say
...re mobile robots. His study on walking stability features dozens of King penguins from Moody Gardens in Galveston. Though these endearing animals may seem unsuited for rough terrain, penguins will travel more than 75 miles across rugged ground terrain to reach their nesting sites. Kurz believes the pengui...Supersized 'island' of resistance genes discovered in an infectious bacterium
...e whole genome of a bacterial strain with specific features is valuable and fast." Resistant A. baumannii has become a major public health concern worldwide. Recently, a high incidence of resistant A. baumannii was reported in US Army service members injured in Afghanistan and Iraq. In France, the resist...How the octopus forms an elbow
...ternal space. The presence of similar structural features and control strategies in articulated limbs (for example, jointed vertebrate arms) and flexible octopus arms suggests that these qualities have evolved convergently in octopuses and in vertebrates, and it also suggests that an articulated limb--contr...Advanced genomics and proteomics improve the diagnosis and treatment of a deadly lung disease
... permits researchers to tease out their functional features and show how they go about their business inside a cell. In the case of Dicer, it shows how the enzyme recognizes RNA and snips it into precise increments. "The fact that it makes these specific sized RNAs is important to the process," Doudna said. ...