Cancer related gene p53 not regulated as indicated by previous tissue culture research
...ade of molecular signals that instructs cells with fatally damaged DNA to self-destruct pivots on the p53 tumor suppressor gene. If p53 is inactivated, as it is in over half of all human cancers, checks and balances on cell growth fail to operate, and body cells start to accumulate mutations, which ultimatel......pact factor to the dustbin. He sees the measure as fatally flawed and highly damaging to the academic community. "The impact factor is a pointless waste of time, energy, and money, and a powerful driver of perverse behaviours in people who should know better," he writes. "It should be killed off, and the...