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Tag: "fat" at biology news

Hormone helps mice 'hibernate,' survive starvation

...pecific cellular receptor that controls the use of fat as energy, spurs a metabolic shift to burning stor...r PPAR-alpha, which is known to control the use of fat as energy. Starving mice without PPAR-alpha become hypoglycemic and quickly die. In analyzing the...

In mice, drug protects against diabetes and atherosclerosis

... For many decades, aP2 was believed to act only in fat cells. In 2001, Hotamisligil and a collaborator discovered that aP2 is also expressed in macrophages, which scavenge and digest cellular debris and microbes in the blood stream. The aP2 signals encourage macrophages to load up on cholesterol and beco...

Fat fish put obesity on the hook

...it off. “Americans—even children—are getting fat at an alarming rate,” said Gerald Weissmann, MD, Editor-in-Chief of The FASEB Journal, “and with this model, we are a step closer to temporarily turning off or diminishing the fat-storing mechanisms that were once crucial to the survival of our speci...

Skimmed milk -- Straight from the cow

...aste. ‘If you can genetically produce milk without fat then that may turn out to be a very good solution ...mmed and semi-skimmed milk means there is a lot of fat left over. Komorowski noted, however, that although the lower-fat milk may be healthier, it will...

Hawaiian treasure, macadamia nuts good for the heart

... percent saturated fat, 18 percent monounsaturated fat and 5 percent polyunsaturated fat. The standard Am... percent saturated fat, 11 percent monounsaturated fat and 5 percent polyunsaturated fat. The macadamia nut diet included macadamia nuts as a snack, mix...

Pistachios lower cholesterol, provide antioxidants

...erage American Diet consisting of 35 percent total fat and 11 percent saturated fat for two weeks. They then tested three diets for four weeks each with a two-week break between each d...

A cherry on top: Tart cherries may alter heart/diabetes factors

...d lower total cholesterol, lower blood sugar, less fat storage in the liver, lower oxidative stress and i...roduction of a molecule that helps the body handle fat and sugar, compared with rats that didn't receive cherries as part of an otherwise similar diet. All...

Keeping the immune system from starting a 'food fight'

...s found that animals lacking a protein enriched in fat cells, called STAMP2, develop acute inflammation i... fluctuations or conditions of nutrient excess. In fat cells, a lack of STAMP2 led to aberrant inflammatory responses to both nutrients and acute inflammat...

Fat screen delivers plant-derived chemical with antidiabetic effects

...reening hundreds of compounds for their effects on fat development, researchers have discovered that an i...drugs and, more generally, provides validation for fat cell screens as a promising strategy for identifying new metabolic drugs, according to the researche...

BMI not accurate indicator of body fat

...onsidered the standard for measuring the amount of fat in a person's body, may not be as accurate as orig...gy. "It really doesn't do a good job of saying how fat a person really is." The problem, especially among younger people and athletes, is that BMI does ...

In obesity, brain becomes 'unaware' of fat

...nsor in the brain that normally detects a critical fat hormone—causing a cascade of events that keeps ene... be responsible for the loss of sensitivity to the fat hormone known as leptin. Therapeutic strategies designed to inhibit SOCS-3 may therefore bypass lept...

Power-boosting signal in muscle declines with age

...genesis, of power-producing mitochondria that burn fat and fuel cells, according to the researchers. T...ople in their seventies show a higher incidence of fat buildup in their muscle and livers and a deficiency in mitochondrial function, Shulman explained. Th...

New player in commitment to life as a fat cell

...d a pivotal new player in early events that commit fat cell precursors to becoming full-blown fat, accord...ffer a novel antiobesity therapy designed to fight fat before it even forms, the researchers said. Known for its role in producing the metabolic byproduct...

Type of stem cell found to reside in transplanted lungs

...d number of cell types such as bone, cartilage and fat cells. However, previous laboratory studies have demonstrated the beneficial effect of these cells in various diseases, such as models of heart attacks and pulmonary fibrosis. The current study of MSCs included 172 bronchoalveolar lavage fluid sam...

How appetite-stimulating brain cells work overtime during fasting

...ing of heat production, or thermogenesis, in brown fat is the activation of mitochondrial uncoupling prot...ormone leptin alone signaled the hypothalamus that fat levels have fallen, leading hypothalamic neurons to activate a program, including hunger, to preserv...

Columbia scientists determine 3-dimensional structure of cell's 'fuel gauge'

...xample, it controls the decision regarding whether fat is stored or burned, based on the amount of energy... and activates "catabolic" functions, like burning fat to make energy. AMPK provides an especially promising drug target for people with type 2 diabetes...

Phthalates now linked to fat, related health risks

... low testosterone appears to cause increased belly fat and pre-diabetes in men. They analyzed urine, bloo...levels of phthalates in their urine had more belly fat and insulin resistance. Researchers adjusted for other factors that could influence the results, suc...

Scripps research team discovers a chemical pathway that causes mice to overeat and gain weight

...e of leptin-an important hormone secreted by white fat cells and a suppressor of appetite. However, in th...and insulin increase, glucose tolerance, and white fat accumulation, and thus may provide a very important animal model for determining the importance of i...

Protein sensor for fatty acid buildup in mitochondria

...PNAS article. "For example, reducing the level of fat in the diet and taking carnitine supplements might...se that we can use to determine if reduced dietary fat and carnitine supplements offer hope in the treatment of PKAN in humans," said Suzanne Jackowski, Ph...

Growth hormone is not the anti-aging bullet for healthy adults

...s (that's a little over four pounds) and decreased fat mass by about two kilograms. But it had no other beneficial effects that we could see. "If you went to a gym pretty regularly, you might get that change without breaking into too much of a sweat, and you wouldn't spend $1,000 to $2,000 a month on ...

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