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Tag: "fasting" at biology news

Blood sugar's manufacture limited by building blocks' supply

...e amino acid breakdown promotes the development of fasting hypoglycemia in the mutant animals by limiting the...vate, but not alanine, rescued the mice from their fasting hypoglycemia. The findings point to a novel form of control over glucose levels, the researchers ...

How appetite-stimulating brain cells work overtime during fasting

...erplay between local T3 production and UCP2 during fasting and reveals a central thermogenic-like mechanism in the regulation of food intake." While it is as yet unproven, the rise in UCP2 in the brain likely also causes changes in temperature in the same way that UCP1 does in brown fat, Diano said. "...

Phthalates now linked to fat, related health risks

...nd waist circumference. Of these men, 651 also had fasting glucose and insulin levels required to calculate insulin resistance. The analysis found that, as expected, several phthalate metabolites showed a positive correlation with abdominal obesity. Indeed, men with the highest levels of phthalates in the...

Walking not enough for significant exercise benefits

...walked. Other markers of overall health, such as fasting plasma glucose levels, response to a two-hour glucose tolerance test and various blood lipids were unaffected by either exercise program. "Our concern is that people might think what matters most is the total number of daily steps accumulated, and n...

Herbal medicine silymarin may help sugar-control in people with type II diabetes

...bound to haemoglobin in blood, as well as reducing fasting blood sugar levels. Silymarin contains a number...the treatment group had a significant reduction in fasting blood glucose levels (p "The results are very encouraging, and we now need to do further large mult...

High estrogen levels associated with dementia in older men

...f dementia at baseline in 1991-1993, at which time fasting blood samples were drawn. The researchers measured the levels of testosterone and estradiol, the major estrogen in humans, in the samples and the men were reexamined for evidence of cognitive decline or dementia in 1994-1996 and 1997-1999 using the C...

Chewing up a key regulator of fat synthesis keeps mice lean despite a high-fat diet

...ing the TRB3 pathway artificially "on" during both fasting and feeding might melt away fat depots. And that's exactly what happened. Mice genetically engineered to express permanently elevated levels of TRB3 protein in fat tissue were 10-20 percent skinnier than normal mice. "Even when we put them on a high...

One-third of adults with diabetes still don't know they have it

...adults age 20 and older continued to have impaired fasting glucose (IFG), a form of pre-diabetes. IFG, in which blood glucose measured after an overnight fast is high but not yet diagnostic of diabetes, increases the risk of heart disease as well as the risk of developing type 2 diabetes. "It's important...

Just the expectation of a mirthful laughter experience boosts endorphins 27 percent, HGH 87 percent

...nt, Berk and his colleagues studied 16 healthy and fasting males, who hadn't exercised for at least a day and were not taking supplement medications. The test subjects had chosen a favorite video. Three days before the experiment, all the subjects were told which group they were randomly selected to be in, e...

Thinner and younger

...orie restriction reduces two key markers of aging: fasting insulin levels and body temperature. More than a...alorie restriction diet ended the study with lower fasting insulin levels and lower core body temperatures. They also had less oxidative damage to their DNA, t...

Hap1 protein links circulating insulin to brain circuits that regulate feeding behavior in mice

... a series of experiments in mice. They found that fasting increased the level of Hap1 in the hypothalamus of the mice and that administering insulin decreased the Hap1 level. Suppressing Hap1 expression through RNA interference reduced mouse food intake and body weight. They also found that reducing Hap1 ...

Phenolic compounds may explain Mediterranean diet benefits

... function in vivo," Dr. Pérez Jiménez said. After fasting overnight, the participants reported to the hospital, where they ate a breakfast of 60 grams of white bread with 40 milliliters of virgin olive oil, a relatively high-fat meal. The meals also included vitamin A supplementation. Over the next four hou...

Insulin pulses keep the liver lean

... also found. The findings suggest that periods of fasting between meals play a critical role in maintaining a lean and healthy liver by allowing insulin levels to rise and fall, said study lead author Sonia Najjar of the Medical University of Ohio. Furthermore, she said, the results emphasize the central r...

Attacks of King George III's madness linked to key metabolism molecule

...oughout his tumultuous reign, can be brought on by fasting and exposure to certain drugs, and is successfully...they have provided "a clear-cut mechanism" linking fasting to an increase in PGC-1 alpha, and, in turn, overactivity of the ALAS-1 gene. The therapeutic effect...

Eliminate Data Analysis Bottlenecks in Drug Discovery

...it shouldn't. The researchers discovered that, in fasting mice, the liver's production of sugar kicked into high gear because amounts and activities of the two proteins, called sirtuin1 and PGC1-alpha, increased when dietary calories weren't available. Once mice were fed, levels of the two proteins went dow...

Computational verification of protein-protein interactions by orthologous co-expression

...it shouldn't. The researchers discovered that, in fasting mice, the liver's production of sugar kicked into high gear because amounts and activities of the two proteins, called sirtuin1 and PGC1-alpha, increased when dietary calories weren't available. Once mice were fed, levels of the two proteins went dow...

PHACCS, an online tool for estimating the structure and diversity of uncultured viral communities using metagenomic information

...it shouldn't. The researchers discovered that, in fasting mice, the liver's production of sugar kicked into high gear because amounts and activities of the two proteins, called sirtuin1 and PGC1-alpha, increased when dietary calories weren't available. Once mice were fed, levels of the two proteins went dow...

Future diabetes drugs may target new protein interaction

...it shouldn't. The researchers discovered that, in fasting mice, the liver's production of sugar kicked into high gear because amounts and activities of the two proteins, called sirtuin1 and PGC1-alpha, increased when dietary calories weren't available. Once mice were fed, levels of the two proteins went dow...

Vascular structure and function improve with diet and exercise

... to 89 mmHg) or pre-diabetes indicated by impaired fasting glucose or impaired glucose tolerance. The average age of patients was 53.3 years. Researchers found that the 22 female and 16 male participants lost weight and improved their exercise capacity on the program. Treadmill tests were used to measure ex...

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