Faster, low cost sequencing technologies needed to drive era of personalized medicine
...ghly a dollar a DNA base to a penny, but are still far out of reach for the public. Zhang's technological vision would enable scientists to sequence billions of base pairs of DNA in a single day. This is the size of an average mammalian genome and is approximately 10,000 times more bases per day than...Dig deeper to find Martian life
...rticles. Ice also holds an advantage because it is far easier to drill through than rock. Even here, surviving cells would be out of the reach of current drills. Other ideal sites include recent craters, because the surface has been exposed to less radiation, and the gullies recently discovered in the si...New fMRI technology making brain tumor surgery safer
...has been used successfully in 12 surgical cases so far at University Hospital. The technology involves collaboration between the Mayfield Clinic, one of the nation's leading physician organizations for clinical care, education, and research of the spine and brain, and UC Radiology, which purchased th...Mechanical 'artificial hearts' can remove need for heart transplant by returning heart to normal
...ination therapy used. The improvement observed was far greater than what has been reported to date for any other therapy in patients with severe, but less advanced, forms of heart failure. "The study also highlights the fact that 'end stage' heart failure can be reversed and that the heart has the cap...Global map shows new patterns of extinction risk
...rything living there is endangered ?the picture is far more complicated, with mammal, bird and amphibian numbers being threatened by different things, in different locations." Examples of geographical locations in which the distribution of endangered species is different include: New Zealand is a...T-ray breakthrough could make detecting disease far easier
...eating an artificial material or 'metamaterial' as far as the T-rays are concerned." "In this way, the T-rays can be focused to the tip of the wire and guided into confined spaces or used to detect small objects, with important implications for disease detection or finding explosive that are hidden." ...Growth factor stimulates rapid extension of key motor neurons in brain
...rons they control in the spinal cord ?extending as far as three feet in adult humans. These neurons degenerate in ALS and related disorders, and their damage contributes to loss of motor function in spinal cord injuries. Since they are embedded among hundreds of other types of neurons in the cerebral c...More species in the tropics because species have been there longer
...er species than temperate regions. So there may be far more loss of diversity going on as we lose tropical rainforests than would be suggested by the number of species alone." ...Salmon farms kill wild fish, study shows
...t salmon. Under natural conditions, the adults are far offshore when the juveniles are migrating out to sea. Fish farms put adult salmon in net pens along the migration routes. The result is a cloud of sea lice through which the juveniles must migrate. "It takes only one or two sea lice to kill a juvenil...Neuron cell stickiness may hold key to evolution of the human brain
...uld help explain why the human brain is capable of far more complex cognitive functions. In a paper publ...ounced than in the brain, where the human model is far larger and more complex than those of all other primates. Previous unbiased whole-genome studies tha...Molecular atlas provides new tool for understanding estrogen-fueled breast cancer
...f binding sites within the cistrome are often very far from the portions of the genes that contain the blueprints for proteins. This overturns the commonly held notion that the ER might favor sites close to the protein-coding regions of genes. "More than 70 percent of breast cancers are ER-positive, me...Nobel Laureate finds 'elegant' explanation for DNA transcribing enzyme's high fidelity
... complementary bases on the DNA template strand is far from sufficient to account for the incredible selectivity of polymerase II, Kornberg said. And the scientists didn’t know either how the polymerase avoids substituting the NTPs that constitute DNA for the correct RNA building blocks, molecules that d...New findings could lead to vaccine for severe malaria
...lacenta. Plasmodium falciparium is the name of by far the most virulent of the four malaria parasites that infect man. It is particularly dangerous in that it also infects the placenta of pregnant women, with fatal consequences for both her and the foetus. This, combined with the often feeble medical re...... cell compartment in the bone marrow, something so far not thought to occur. The study proves that beta-catenin plays a central role in determining whether blood cells form or not. On the other hand, an overactive Wingless pathway doesn't seem to damage cells that already exist. Thus beta-catenin seems ...... activity than early embryo development. There's a far greater diversity of RNAs in the egg cell than in the two-cell embryo, perhaps because the embryo is independent and the pre-ovulatory egg must still coordinate signals with surrounding tissues. Another discovery was that 80% of the expressed genes...New brain-chemistry differences found in depressed women
...ho later responded to antidepressant treatment had far lower mu-opioid responses than women who did not respond to medication. The new findings add the mu-opioid system to the list of brain systems that appear to be altered in depression. Others include the corticotrophin-releasing hormone system, an...NHGRI aims to make DNA sequencing faster, more cost effective
...new approaches have shown significant promise, yet far more exploration and development are needed if they are to be useful to the average researcher or physician," said Jeffery Schloss, Ph.D., NHGRI's program director for technology development. "We look forward to seeing which of these technologies ful......ys. But the evidence is strong that the answer, as far as the worm is concerned, lies on the chromosomes' Pairing Centers. ...'Protecting virus' offers instant flu protection and converts flu infections into their own vaccines
...3 weeks to become fully effective. Experiments so far show that a single dose of protecting virus can be given 6 weeks before an infection with flu virus and be effective. This could also have a substantial advantage over anti-viral drugs that only give less than 24-hour protection. Another advantage i...Good times ahead for dinosaur hunters, according to U of Penn scientist's dinosaur census
...rnest in the 19th century, only 527 genera have so far been found, although that number is currently changing at the rate of 10 to 20 per year. "It's a safe bet that a child born today could expect a very fruitful career in dinosaur paleontology," said Dodson, professor of anatomy in Penn's School of Ve...