Soft-cell approach cuts animal tests
... for toxicity to be expressed as organ or organism failure many months or even years down the track from initial exposure. The application of in vitro methods could open new possibilities for toxicity testing of industrial chemicals, occupational and environmental contaminants, combustion products and re...In obesity, brain becomes 'unaware' of fat
...thway remains ready to respond. “Obesity is not a failure of will power, it is a biological failure,?said Michael Cowley of Oregon Health & Science University of his group’s findings in the mice. “The brain is not aware that the body is obese.? If the same is true in humans, he added, people may be co...Row over study puts Korea's scientific community under scrutiny again
.... Dr Kim claims a paper about premature ovarian failure that he originally published in the Korean Journal of Obstetrics and Gynaecology in January 2004 was translated and republished in the American journal Fertility and Sterility under a different title and with different authors in December 2005. Wh...Heart failure: Intervention possibilities from imaging programmed cell loss
...nvasively identify cell loss—or apoptosis—in heart failure patients using annexin A5 imaging," explained Leo ...med on a small group of heart patients. "Heart failure is a major health care problem," said Hofstra, "and researchers are looking at novel ways to improve...Genome of yellow fever/dengue fever mosquito sequenced
...ing to the article in Science Express, the general failure to date of conventional disease prevention strategies for most mosquito-borne pathogens provides a strong incentive to explore and develop novel control strategies that efficiently disrupt the transmission cycle or enhance existing strategies. The Ae...Percutaneous aortic valve replacement safe, successful in high-risk patients
... the procedure. In addition, the severity of heart failure significantly improved, as gauged by both B-type natriuretic peptide (NT-BNP), a protein produced by the ventricles of the heart during heart failure, and New York Heart Association (NHYA) classification. After the procedure, patients were ranked in ...Nitric oxide: Key to cardiovascular and pulmonary function and drug effectiveness
...a adrenergic receptor agonists used in acute heart failure or in inhalers for asthma, lose their effectivenes...s -- why specific drugs for such diseases as heart failure or asthma lose their effectiveness over time. Almost half of all drugs on the market today, as we...Hearts of male and female rainbow trout are different
...st energy demanding organs of the human body. Its failure to function properly accounts for 600,000 deaths each year. Similarly, the rainbow trout, native to the Pacific Northwest and beloved as a sport- and food fish, requires dynamic and sustained cardiac function to maintain its health and swimming activ...Gene expression patterns predict rapid decline in idiopathic pulmonary fibrosis patients
... much more rapid progression to complete pulmonary failure and death without a lung transplant. Based on observations in the clinic that some IPF patients display a more rapidly progressing disease course, researchers at the Simmons Center for Interstitial Lung Disease at the University of Pittsburgh School...454 sequencing identifies HIV drug resistance at early stage
...d the prediction of early antiretroviral treatment failure with strong statistical significance. “Current ge...utations present at the 1% level lead to premature failure of therapy” explained Michael Kozal, M.D. the senior author on the study. “In the future, hopefully ......r it can stem from a deeper problem such as kidney failure or liver disease. It can be a serious side effect of cancer therapies or powerful painkillers like morphine. For some people, chronic itching can be very disruptive, interfering with sleep or giving rise to scratching that leads to scarring. Effectiv...