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Tag: "failure" at biology news

Little known DNA repair enzyme may be a tumor suppressor gene

...fits for patients with hypertension, angina, heart failure and sexual dysfunction, according to background information in the article. Prior studies suggest that L-arginine has the potential to reduce vascular (blood vessel) stiffness. Steven P. Schulman, M.D., of Johns Hopkins Medical Institutions, Baltimo...

An elephant tail

...fits for patients with hypertension, angina, heart failure and sexual dysfunction, according to background information in the article. Prior studies suggest that L-arginine has the potential to reduce vascular (blood vessel) stiffness. Steven P. Schulman, M.D., of Johns Hopkins Medical Institutions, Baltimo...

Protein found to control tumor growth in certain breast cancers

...ding the regulation of tumor cell growth where the failure of malignant cells to undergo cell death led to tu...ivity to estrogen-induced cell proliferation and a failure to undergo Nod1-dependent apoptosis in vitro. Taking these initial findings one step further, res...

Researches discover gene critical for protection against septic-shock-induced death

... injury, acute respiratory failure, multiple organ failure or death. Controlling inflammation is thus a centr...pathological damage, the main cause of multi-organ failure during septic shock. Hence, Nrf2 can be a promising therapeutic target for attenuating septic-relate...

New human retrovirus originated in mice

... virus may well have flourished as a result of the failure of the defense mechanism; and other factors such as chronic inflammation may play a more direct role in the cancer. The discovery of the new virus was made by an interdisciplinary research team led by Robert Silverman of Cleveland Clinic and HHMI in...

UF scientists test improved gene therapy method for hereditary heart conditions

...ly of diseases called long Q-T syndrome, the heart failure category where many folks have been attempting to modify contractility with gene transfer," said Byrne, who also is affiliated with the UF Genetics Institute. "We're using the very same strategies used with medical treatment but without ongoing use o...

Study pinpoints protein's role in cancer spread

...in that acts as a guardian of the normal cell. Its failure to do its job properly is associated with many types of cancer. If p53 is being destroyed by another protein in a cancer cell, then it offers an excellent target when designing new anti-cancer drugs. This research suggests MDM2 is just such a target....

Heart has enough oxygen to survive hypothermia, CPR crucial

...r group were more likely to experience fatal heart failure during rewarming. The issue is important because...s of severe hypothermia almost always causes heart failure of varying severity, but little is known about why that happens, said Torkjel Tveita, the study's se...

Novel therapy combinations gain ground in treating hepatitis

...ften leading to more serious conditions like liver failure and even death. Several different forms of hepati...ted. Acetaminophen as a co-factor in acute liver failure due to viral hepatitis determined by measurement of acetaminophen-protein adducts [Abstract S1002] ...

New egg freezing technique offers hope to hundreds of women

...," she said. One reason for the high percentage of failure after fertilisation could be the damage done to the structure of the egg during freeze-thawing, in particular to a part called the meiotic spindle which is involved in cell division. The meiotic spindle is a bundle of microtubules, some of which beco...

Tumor wizardry wards off attacks from the immune system

...illance." Linehan believes this could explain the failure of many experimental anti-cancer vaccines. Such vaccines are designed to rev up the immune response to cancer cells so that the immune system can attack tumors. But a tumor shielded with T-reg cells could potentially circumvent the immune system's at...

Diabetes hits 275 Australians each day as pandemic spreads

... of heart disease, strokes, amputations and kidney failure will have a profound impact on Australia's future health budgets. "What we have done is to quantify the risks. We now have hard data which give our Federal and State governments the first tangible indication of the size of the problem which will bur...

AIDS vaccine research offers new insights on survival

... go on to live longer." Until now, the success or failure of this type of T-cell vaccine has been determined by measures of virus levels and total counts of CD4+ helper T-cells, which are indicative of infection control in monkeys infected with the AIDS virus. As in previous studies, this new research fo...

Reversing 'hibernating' heart muscle focus of UB researchers

...rnating myocardium" that can cause disabling heart failure and sudden death. Hibernating myocardium is a c...ating myocardium are common in patients with heart failure arising from coronary artery disease, Canty noted. "Determining how this impacts prognosis is the fo...

Healing the heart with bone marrow cells

...in preventing the vicious downward spiral of heart failure in which the heart progressively thins and dilates..., more than half of patients with congestive heart failure die within five years of initial diagnosis. "Cardiovascular diseases are the most important cause o...

A surprise about our body clock

...in preventing the vicious downward spiral of heart failure in which the heart progressively thins and dilates..., more than half of patients with congestive heart failure die within five years of initial diagnosis. "Cardiovascular diseases are the most important cause o...

'Cellular antennae' on algae give clues to how human cells receive signals

... unable to respond to the signaling molecules. The failure to activate the chain of chemical reactions indicated that IFT was necessary for this function. Analysis showed that the cilia signaling process was similar to that found in human cells, such as those in the nose involved in the sense of smell and ...

Study defines effective microbicide design for HIV/AIDS prevention

...crobial ingredients, in determining the success or failure of microbicides, according to the researchers. Yet, they add, most scientists have concentrated on improving the antimicrobial compounds themselves, rather than their delivery. "There is a huge push to produce microbicides that would have any effec...

Mouse study reveals new clues about virulence of 1918 influenza virus

...rolled inflammatory response leading to rapid lung failure and death. To test this idea, Dr. Tumpey infected mice intranasally with one of four types of flu virus: human seasonal flu virus from a strain that circulated in Texas in 1991; lab-made viruses containing either two or five of eight viral genes f...

Inheriting a tendency to brain infection

...encies. "Understanding the genetic basis of the failure of the immune system should make it possible to devise novel ways to make it succeed," he said. Since the mid-1950s, most infectious disease researchers have believed that the genetic components of infectious disease are complex, involving differe...

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