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Tag: "failure" at biology news

Genes linked to treatment resistance in children with leukemia

...ne marrow and the most common reason for treatment failure in childhood ALL. This risk was further increased if the child also had a TYMS 3/3 genotype. No genotype was associated with hematological relapse among patients in the lower-risk arm of the study. The researchers also looked for evidence of leukemi...

Researchers develop gene therapy to reverse pulmonary arterial hypertension

...ently limited for a disease that can lead to heart failure and death within a few years. The researchers have shown that Survivin, a protein almost exclusively expressed in cancer, is also heavily expressed in both human and animal lung arteries with PAH. Survivin is an inhibitor of apoptosis--or programmed...

Eleven gene 'signature' reliably predicts cancer prognosis

...s a death from cancer signature predicting therapy failure in patients with multiple types of cancer ...

Emerald Spectre haunts Ontario's ash forests

...er in eastern Canada and the United States. It's a failure that would cost billions of dollars in lost timber and ornamental trees, and dramatically change the forest and neighbourhood landscape in eastern North America - with even more impact than Dutch elm disease. The soon-to-be published study is the fi...

Researchers find Amchitka seafood safe for now

...he high quality of the studies reported, and their failure to find evidence of the release of radioactivity from the shot cavities into the surrounding environment, the results that are presented should be reassuring to concerned stakeholders." Complexity from beginning to end: "I continue to be in awe of t...

Researcher says flu responders can learn from 1918 epidemic

...no successes. You could only talk about degrees of failure and success." ...

Gene therapy reverses genetic mutation responsible for heart failure in muscular dystrophy

...time used gene therapy to successfully treat heart failure and other degenerative muscle problems in an anima...e heart in addition to secondary symptoms of heart failure such as liver problems, swollen lungs and a severe buildup of fluid in the chest and peritoneal cavi...

Master regulatory gene found that guides fate of blood-producing stem cells

...er make more stem cells in the case of bone-marrow failure and for transplantation, or to force the cells to differentiate, in the case of leukemia, where too many HSCs are made. ...

Past illegal blood donation in China linked to hepatitis C virus infection

... donors during the 1980s and early 1990s, and that failure to screen for HCV in transfusion recipients increased their risk of infection as well, according to an article in the November 15 issue of The Journal of Infectious Diseases, now available online. Some blood donation facilities in rural China illega...

A little telomerase isn't enough

...er than their parents, the researchers report. The failure of telomerase to lengthen these telomeres explains...ice had severely shortened telomeres and exhibited failure of organs that have high turnover of their cells -- the bone marrow and intestine among them. "We t...

Viagra's hidden help for wildlife

... the widespread availability of aspirin. "But the failure to achieve an erection isn't comparable to having a headache or the many other ailments for which consumers still prefer TCM treatments. Furthermore, Viagra differs from many other Western drugs, in that the effects are rapid and visible to the naked...

Scientists map one of biology's critical light-sensing structures

... events, says Vierstra, is a key to the success or failure of most crops, as most of what we eat comes from seeds and fruits produced by flowers. In another scenario, it may be possible to dampen the role of phytochromes in crop plants to avoid having them compete with each other for light when grown close ...

Cells from amniotic fluid used to tissue-engineer a new trachea

...ls; this can lead to many complications, including failure of the repair. Fetal surgery would eliminate these interventions and their resulting problems. "The fetus doesn't need the trachea, so the repair would have time to heal in utero," Fauza explains. "And fetal healing is very good it's better than ad...

Penicillin, amoxicillin: Step aside for strep throat treatment

...n. "Most doctors are shocked to learn of the high failure rates of the older medications," said Pichichero, ..., Pichichero said, and doctors accept some risk of failure as a trade-off for other factors like convenience, cost to families, and likelihood that a less powe...

Implantable pumps extend lives of patients too sick for transplant

...e lives of the sickest patients in end-stage heart failure who are not candidates for heart transplantation, ...increasingly being considered as a long-term heart failure destination therapy, said the researchers. In the current trial, the researchers found that patient...

Discovering the first steps in transcription-coupled repair

...be lethal to cells and to the organism. In humans, failure of transcription-coupled repair is the cause of Cockayne Syndrome, an extreme form of accelerated aging that is inevitably fatal early in life. Cooper and her colleagues illuminated, for the first time, the roles played by two important proteins in ...

Feds give researchers ok for safety test of adult stem cells in patients with heart disease

...lerosis, for example, can lead to congestive heart failure and heart attacks. About 5 million people in the United States have heart failure and the number is growing. Each year, another 550,000 people are diagnosed for the first time. It co...

RNA splicing occurs in nerve-cell dendrites

...help maintain the system over a lifetime. However, failure in protein regulation or proper expression in neurons may give rise to cognitive dysfunction. "Most neurodegenerative and psychiatric illnesses exhibit dendrite dysfunction, therefore, the inability to properly generate spliced RNAs in dendrites or p...

Simple idea to dramatically improve dengue vaccinations

...vative new study explains, for the first time, the failure of previous attempts to vaccinate against the four known Dengue viruses, and it suggests a very simple solution ?injecting the four vaccines simultaneously at different locations on the body. A mosquito-born disease, Dengue kills tens of thousands o...

Learning to love bacteria: Stanford scientist highlights bugs' benefits

...ponsible for some of the things we see such as the failure of the immune system to act appropriately?" he asked. The only answer to date is: "It's complicated." Instead of a persistent infection, some people get very ill from organisms such as Salmonella, H. pylori, tuberculosis and meningitis. How the immu...

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